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The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. Additionally we are shipping MLLT11 Antibodies (21) and many more products for this protein.
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Findings indicate that breast cancer cells with a hyperactive AF1q/TCF7 (show TCF7 Proteins)/CD44 (show CD44 Proteins) regulatory axis in the primary sites may represent "metastatic founder cells" which have invasive properties.
Results demonstrate that AF1q gene transcription is regulated by REST through direct binding at -383 to -363 bp of AF1q promoter.
AF1Q had a KFERQ-like motif.
AF1q plays a role in the onset of basal apoptosis in ovarian cancer cells, thus providing new information about the activity of this protein whose biologic functions are mostly unknown
Using in vitro assays based on either forced expression or shRNA-mediated silencing of AF1q, the study provides evidence that the protein promotes T- over B-cell differentiation in multipotent hematopoietic progenitors.
AF1q up-regulation of BAD is through its effect on NF-kappaB (show NFKB1 Proteins) and this may hint of its oncogenic mechanism in cancer.
The ectopic expression of human AF1q triggered the expression of the neuronal marker TuJ1 in non-neuronal human embryonic kidney (HEK) cells.
overexpression of AF1Q leads to more progression in human breast cancer
The study provides the first evidence that AF1q plays a critical role in the regulation of apoptosis and drug resistance.
high AF1q expression is a poor prognostic marker for adult patients with normal cytogenetics acute myeloid leukemia (show BCL11A Proteins)
MLLT11 is a pan-neuronal marker, suggesting a role in neural differentiation in the central nervous system and neural crest-cell derived peripheral ganglia
The mouse Af1q, homologue of human AF1q, was found to be significantly up-regulated during the neuronal production from neural stem cells
The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. t(1\;11)(q21\;q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21 in 2 infants with acute myelomonocytic leukemia have been demonstrated. The N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23. This gene encodes 90 amino acids. It was found to be highly expressed in the thymus but not in peripheral lymphoid tissues. In contrast to its restricted distribution in normal hematopoietic tissue, this gene was expressed in all leukemic cell lines tested.
, ALL1 fused gene from chromosome 1q
, ALL1-fused gene from chromosome 1q
, zinc finger protein 692
, AF1Q protein