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anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 (MLLT3) Antibodies

mouse homolog regulates pattern formation during embryogenesis. Additionally we are shipping Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MLLT3 4300 P42568
MLLT3 70122 A2AM29
MLLT3 114510  
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Top anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 Antibodies at antibodies-online.com

Showing 10 out of 67 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-MLLT3 Antibody Titration: 0.2-1 ug/mlPositive Control: HepG2 cell lysate Host: Rabbit  Target Name: MLLT3  Sample Tissue: Hela  Antibody Dilution: 1.0 µg/mL MLLT3 is supported by BioGPS gene expression data to be expressed in HeLa 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of AF9 (MLLT3) Antibody (C-term K486) (ABIN390128) in 293 cell line lysates (35 µg/lane). MLLT3(arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB The anti-MLLT3 Pab (ABIN390129) is used in Western blot to detect MLLT3 in mouse cerebellum tissue lysate MLLT3 Antibody (C-term) (ABIN390129) western blot analysis in 293 cell line lysates (35 µg/lane).This demonstrates the MLLT3 antibody detected the MLLT3 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Dog Rabbit Un-conjugated WB WB Suggested Anti-MLLT3 Antibody Titration: 0.2-1 ug/mlPositive Control: HepG2 cell lysate Host: Rabbit  Target Name: MLLT3  Sample Tissue: Human Fetal Brain  Antibody Dilution: 1.0 µg/mL 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB The anti-MLLT3 Pab (ABIN390130) is used in Western blot to detect MLLT3 in HL60 tissue lysate 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated ChIP, ICC, IF, IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: THP-1 7.5% SDS PAGE antibody diluted at 1:1000 IHC-P Image Immunohistochemical analysis of paraffin-embedded D54 xenograft, using AF9, antibody at 1:750 dilution. 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated EIA, IHC (p) 50 μg Log in to see 6 to 8 Days
$500.50
Details

MLLT3 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , ,
,
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, , , , ,
Mouse (Murine)


Rat (Rattus)


Top referenced anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 Antibodies

  1. Human Polyclonal MLLT3 Primary Antibody for IHC (p), WB - ABIN390128 : Iida, Seto, Yamamoto, Komatsu, Tojo, Asano, Kamada, Ariyoshi, Takahashi, Ueda: MLLT3 gene on 9p22 involved in t(9;11) leukemia encodes a serine/proline rich protein homologous to MLLT1 on 19p13. in Oncogene 1993 (PubMed)
    Show all 5 references for ABIN390128

  2. Human Polyclonal MLLT3 Primary Antibody for EIA, WB - ABIN358675 : Nakamura, Alder, Gu, Prasad, Canaani, Kamada, Gale, Lange, Crist, Nowell: Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs. in Proceedings of the National Academy of Sciences of the United States of America 1993 (PubMed)
    Show all 3 references for ABIN358675

  3. Human Polyclonal MLLT3 Primary Antibody for WB - ABIN390129 : Strissel, Strick, Tomek, Roe, Rowley, Zeleznik-Le: DNA structural properties of AF9 are similar to MLL and could act as recombination hot spots resulting in MLL/AF9 translocations and leukemogenesis. in Human molecular genetics 2000 (PubMed)
    Show all 3 references for ABIN390129

  4. Human Polyclonal MLLT3 Primary Antibody for EIA, IHC (p) - ABIN358673 : Bitoun, Oliver, Davies: The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling. in Human molecular genetics 2007 (PubMed)
    Show all 2 references for ABIN358673

  5. Cow (Bovine) Polyclonal MLLT3 Primary Antibody for WB - ABIN2780604 : Wei, Wunderlich, Fox, Alvarez, Cigudosa, Wilhelm, Zheng, Cancelas, Gu, Jansen, Dimartino, Mulloy: Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia. in Cancer cell 2008 (PubMed)

More Antibodies against Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 Interaction Partners

Human Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 (MLLT3) interaction partners

  1. Studies identified the evolutionarily conserved Af9 YEATS domain as a novel acetyllysine-binding module and established a direct link between histone acetylation and DOT1L (show DOT1L Antibodies)-mediated H3K79 methylation in transcription control.

  2. AF9 and its homolog ENL directly interact with AF4.

  3. Abrogation of Rac1 signaling causes DNA double-strand breaks in acute monocytic leukemia (show KAT6B Antibodies) cells harbouring the MLL (show MLL Antibodies)-AF9 oncogene (show RAB1A Antibodies).

  4. Interaction with CBX8 (show CBX8 Antibodies) precludes AF9-DOT1L (show DOT1L Antibodies) binding.

  5. We demonstrate that leukemogenic activity of MLL (show MLL Antibodies)-AF9 requires RUVBL2 (RuvB-like 2 (show RUVBL2 Antibodies)), an AAA (show APP Antibodies)+ ATPase (show DNAH8 Antibodies) family member that functions in a wide range of cellular processes, including chromatin remodeling and transcriptional regulation.

  6. neonatal cells expressing MLL (show MLL Antibodies)-AF9 were enriched for gene signatures associated with poor prognosis

  7. AF9 functions as a signaling hub that regulates transcription through dynamic recruitment of cofactors in normal hematopoiesis and in acute leukemia.

  8. Identification of genes that define transcription factor networks and important genetic pathways acting during progression of leukemia induced by MLL (show MLL Antibodies) fusion oncogenes.

  9. we identified a novel fusion gene consisted of PAX5 (show PAX5 Antibodies) and MLLT3 during progression from chronic phase to blastic phase in chronic myeloid leukemia (show BCL11A Antibodies)

  10. MLL (show MLL Antibodies)-AF9-negative U937 cells but not positive MLL (show MLL Antibodies)-AF9 THP-1 (show GLI2 Antibodies) cells, suggesting that the toxocity ting was not antibody-mediated by antibodies against MLL (show MLL Antibodies)-AF9 protein.

Mouse (Murine) Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 (MLLT3) interaction partners

  1. Data suggest that RAS-homolog enriched in brain protein (Rheb1) promotes MLL-AF9 fusion protein initiated acute myeloid leukemia (AML) progression through target of rapamycin complex 1 (mTORC1) signaling pathway.

  2. Using a PDK1 (show PDPK1 Antibodies) conditional deletion MLL (show MLL Antibodies)-AF9 murine AML (show RUNX1 Antibodies) model, we revealed that the deletion of PDK1 (show PDPK1 Antibodies) prolonged the survival of AML (show RUNX1 Antibodies) mice by inducing LSC (show ARHGEF1 Antibodies) apoptosis

  3. define a specific pairing of two amino acids that creates a salt bridge between MLLT1 (show MLLT1 Antibodies)/3 and AFF proteins that is critically important for MLL (show MLL Antibodies)-mediated transformation of HPCs

  4. Af9 mediates site-selective physical and functional recruitment of Rnf2 (show RNF2 Antibodies) to the alpha-ENaC (show SCNN1A Antibodies) promoter to constrain basal alpha-ENaC (show SCNN1A Antibodies) transcription in collecting duct cells.

  5. Impaired alphaENaC (show SCNN1A Antibodies) expression due to failure to inhibit Dot1a-Af9 may play an important role in the early stages of pseudohypoaldosteronism type 1 in MR(-/-) mice.

  6. We demonstrate that leukemogenic activity of MLL (show MLL Antibodies)-AF9 requires RUVBL2 (RuvB-like 2 (show RUVBL2 Antibodies)), an AAA (show AAAS Antibodies)+ ATPase (show DNAH8 Antibodies) family member that functions in a wide range of cellular processes, including chromatin remodeling and transcriptional regulation.

  7. Therefore, Dot1a and Af9 as aldosterone-downregulated targets are negative regulators of endothelin-1 (show EDN1 Antibodies) transcription in vitro and in vivo, and may be considered as new potential therapeutic targets of kidney injury in diabetes.

  8. It was concluded that +78/+92 of the epithelial Na+ channel alpha (show SCNN1A Antibodies)-subunit (show POLG Antibodies) represents the primary Af9 binding site involved in recruiting Dot1a to repress basal and aldosterone-sensitive Na+ channel alpha-subunit (show POLG Antibodies) transcription.

  9. PRC2 supports aberrant self-renewal in a mouse model of MLL (show MLL Antibodies)-AF9;Nras (show NRAS Antibodies)(G12D) acute myeloid leukemia (show BCL11A Antibodies).

  10. The role of polycomb (show CBX2 Antibodies) repressive complex 2 (PRC2) function in leukemia development and progression, is reported.

Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 (MLLT3) Antigen Profile

Protein Summary

mouse homolog regulates pattern formation during embryogenesis

Gene names and symbols associated with MLLT3

  • myeloid/lymphoid or mixed lineage-leukemia translocation to 3 homolog (Drosophila) (mllt3) antibody
  • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 (MLLT3) antibody
  • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 (Mllt3) antibody
  • 2210011H10Rik antibody
  • 2610012I03Rik antibody
  • 3830408D16Rik antibody
  • Af-9 antibody
  • Af9 antibody
  • D4Ertd321e antibody
  • fc39c11 antibody
  • wu:fc39c11 antibody
  • YEATS3 antibody
  • zgc:110210 antibody

Protein level used designations for MLLT3

protein AF-9 , ALL1-fused gene from chromosome 9 protein , YEATS domain-containing protein 3 , myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 3 , myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein , myeloid/lymphoid or mixed lineage-leukemia translocation to 3 homolog , myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein homolog , myeloid/lymphoid or mixed-lineage leukemia, translocated to, 3 , myeloid/lymphoid or mixed-lineage leukemia,translocated to, 3 (trithorax homolog, Drosophila) , translocated to, 3

GENE ID SPECIES
550517 Danio rerio
4300 Homo sapiens
521962 Bos taurus
70122 Mus musculus
481556 Canis lupus familiaris
114510 Rattus norvegicus
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