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Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 (MLLT3) ELISA Kits

mouse homolog regulates pattern formation during embryogenesis [RGD, Feb 2006].. Additionally we are shipping Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 Antibodies (65) and Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human MLLT3 MLLT3 4300 P42568
Anti-Mouse MLLT3 MLLT3 70122 A2AM29
Anti-Rat MLLT3 MLLT3 114510  
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More ELISA Kits for Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 Interaction Partners

Human Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 (MLLT3) interaction partners

  1. Studies identified the evolutionarily conserved Af9 YEATS domain as a novel acetyllysine-binding module and established a direct link between histone acetylation and DOT1L-mediated H3K79 methylation in transcription control.

  2. AF9 and its homolog ENL directly interact with AF4.

  3. Abrogation of Rac1 signaling causes DNA double-strand breaks in acute monocytic leukemia (show KAT6B ELISA Kits) cells harbouring the MLL (show MLL ELISA Kits)-AF9 oncogene (show RAB1A ELISA Kits).

  4. Interaction with CBX8 precludes AF9-DOT1L binding.

  5. We demonstrate that leukemogenic activity of MLL (show MLL ELISA Kits)-AF9 requires RUVBL2 (RuvB-like 2 (show RUVBL2 ELISA Kits)), an AAA (show APP ELISA Kits)+ ATPase (show DNAH8 ELISA Kits) family member that functions in a wide range of cellular processes, including chromatin remodeling and transcriptional regulation.

  6. neonatal cells expressing MLL (show MLL ELISA Kits)-AF9 were enriched for gene signatures associated with poor prognosis

  7. AF9 functions as a signaling hub that regulates transcription through dynamic recruitment of cofactors in normal hematopoiesis and in acute leukemia.

  8. Identification of genes that define transcription factor networks and important genetic pathways acting during progression of leukemia induced by MLL (show MLL ELISA Kits) fusion oncogenes.

  9. we identified a novel fusion gene consisted of PAX5 (show PAX5 ELISA Kits) and MLLT3 during progression from chronic phase to blastic phase in chronic myeloid leukemia (show BCL11A ELISA Kits)

  10. MLL (show MLL ELISA Kits)-AF9-negative U937 cells but not positive MLL (show MLL ELISA Kits)-AF9 THP-1 (show GLI2 ELISA Kits) cells, suggesting that the toxocity ting was not antibody-mediated by antibodies against MLL (show MLL ELISA Kits)-AF9 protein.

Mouse (Murine) Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 (MLLT3) interaction partners

  1. Data suggest that RAS-homolog enriched in brain protein (Rheb1) promotes MLL-AF9 fusion protein initiated acute myeloid leukemia (AML) progression through target of rapamycin complex 1 (mTORC1) signaling pathway.

  2. Using a PDK1 (show PDPK1 ELISA Kits) conditional deletion MLL (show MLL ELISA Kits)-AF9 murine AML (show RUNX1 ELISA Kits) model, we revealed that the deletion of PDK1 (show PDPK1 ELISA Kits) prolonged the survival of AML (show RUNX1 ELISA Kits) mice by inducing LSC (show ARHGEF1 ELISA Kits) apoptosis

  3. define a specific pairing of two amino acids that creates a salt bridge between MLLT1/3 and AFF proteins that is critically important for MLL (show MLL ELISA Kits)-mediated transformation of HPCs

  4. Af9 mediates site-selective physical and functional recruitment of Rnf2 (show RNF2 ELISA Kits) to the alpha-ENaC (show SCNN1A ELISA Kits) promoter to constrain basal alpha-ENaC (show SCNN1A ELISA Kits) transcription in collecting duct cells.

  5. Impaired alphaENaC (show SCNN1A ELISA Kits) expression due to failure to inhibit Dot1a-Af9 may play an important role in the early stages of pseudohypoaldosteronism type 1 in MR(-/-) mice.

  6. We demonstrate that leukemogenic activity of MLL (show MLL ELISA Kits)-AF9 requires RUVBL2 (RuvB-like 2 (show RUVBL2 ELISA Kits)), an AAA (show AAAS ELISA Kits)+ ATPase (show DNAH8 ELISA Kits) family member that functions in a wide range of cellular processes, including chromatin remodeling and transcriptional regulation.

  7. Therefore, Dot1a and Af9 as aldosterone-downregulated targets are negative regulators of endothelin-1 (show EDN1 ELISA Kits) transcription in vitro and in vivo, and may be considered as new potential therapeutic targets of kidney injury in diabetes.

  8. It was concluded that +78/+92 of the epithelial Na+ channel alpha (show SCNN1A ELISA Kits)-subunit (show POLG ELISA Kits) represents the primary Af9 binding site involved in recruiting Dot1a to repress basal and aldosterone-sensitive Na+ channel alpha-subunit (show POLG ELISA Kits) transcription.

  9. PRC2 supports aberrant self-renewal in a mouse model of MLL (show MLL ELISA Kits)-AF9;Nras (show NRAS ELISA Kits)(G12D) acute myeloid leukemia (show BCL11A ELISA Kits).

  10. The role of polycomb (show CBX2 ELISA Kits) repressive complex 2 (PRC2) function in leukemia development and progression, is reported.

Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 (MLLT3) Antigen Profile

Antigen Summary

mouse homolog regulates pattern formation during embryogenesis

Gene names and symbols associated with MLLT3

  • myeloid/lymphoid or mixed lineage-leukemia translocation to 3 homolog (Drosophila) (mllt3) antibody
  • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 (MLLT3) antibody
  • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 (Mllt3) antibody
  • 2210011H10Rik antibody
  • 2610012I03Rik antibody
  • 3830408D16Rik antibody
  • Af-9 antibody
  • Af9 antibody
  • D4Ertd321e antibody
  • fc39c11 antibody
  • wu:fc39c11 antibody
  • YEATS3 antibody
  • zgc:110210 antibody

Protein level used designations for MLLT3

protein AF-9 , ALL1-fused gene from chromosome 9 protein , YEATS domain-containing protein 3 , myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 3 , myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein , myeloid/lymphoid or mixed lineage-leukemia translocation to 3 homolog , myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein homolog , myeloid/lymphoid or mixed-lineage leukemia, translocated to, 3 , myeloid/lymphoid or mixed-lineage leukemia,translocated to, 3 (trithorax homolog, Drosophila) , translocated to, 3

GENE ID SPECIES
550517 Danio rerio
4300 Homo sapiens
521962 Bos taurus
70122 Mus musculus
481556 Canis lupus familiaris
114510 Rattus norvegicus
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