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anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 4 (MLLT4) Antibodies

MLLT4 encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. Additionally we are shipping Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 4 Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MLLT4 4301 P55196
MLLT4 17356 Q9QZQ1
MLLT4 26955 O35889
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Top anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 4 Antibodies at antibodies-online.com

Showing 10 out of 33 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated IF, IP, IHC, WB Western blot analysis of AF6 on a PC-12 cell lysate (Rat neuroblastoma, ATCC CRL-1721). Lane 1: 1:125, lane 2: 1:250, lane 3: 1:500 dilution of the mouse anti-AF6 antibody. Immunofluorescence staining of mouse macrophages. 50 μg Log in to see 5 to 6 Days
$205.42
Details
Dog Mouse Un-conjugated EIA, IP, WB   0.1 mg Log in to see 6 to 8 Days
$643.50
Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-MLLT4 Antibody Titration: 1.25ug/mlELISA Titer: 1:312500Positive Control: HepG2 cell lysate WB Suggested Anti-MLLT4  Antibody Titration: 1.25 µg/mL ELISA Titer: 1:312500  Positive Control: HepG2 cell lysate  MLLT4 is strongly supported by BioGPS gene expression data to be expressed in Human HepG2 cells 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 8 to 10 Days
$493.17
Details
Human Rabbit Un-conjugated EIA, IHC (p) 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated IHC (p), ELISA, WB Anti-MLLT4 / Afadin antibody IHC staining of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN962146 concentration 5 ug/ml. 50 μg Log in to see 8 to 10 Days
$595.83
Details
Human Rabbit Un-conjugated IHC (p), ELISA Human Spleen (formalin-fixed, paraffin-embedded) stained with MLLT4 antibody ABIN214676 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated ELISA, WB 100 μg Log in to see 2 to 3 Days
$343.75
Details
Human Rabbit Un-conjugated IHC, ELISA 0.05 mg Log in to see 2 to 3 Days
$481.25
Details
Human Rabbit Un-conjugated IHC (p), ELISA 50 μg Log in to see 11 to 13 Days
$541.80
Details

MLLT4 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
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Top referenced anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 4 Antibodies

  1. Human Monoclonal MLLT4 Primary Antibody for IF, IP - ABIN968143 : Buchert, Schneider, Meskenaite, Adams, Canaani, Baechi, Moelling, Hovens: The junction-associated protein AF-6 interacts and clusters with specific Eph receptor tyrosine kinases at specialized sites of cell-cell contact in the brain. in The Journal of cell biology 1999 (PubMed)
    Show all 5 references for ABIN968143

  2. Dog (Canine) Monoclonal MLLT4 Primary Antibody for EIA, IP - ABIN1108256 : Sakisaka, Nakanishi, Takahashi, Mandai, Miyahara, Satoh, Takaishi, Takai: Different behavior of l-afadin and neurabin-II during the formation and destruction of cell-cell adherens junction. in Oncogene 1999 (PubMed)
    Show all 2 references for ABIN1108256

More Antibodies against Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 4 Interaction Partners

Human Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 4 (MLLT4) interaction partners

  1. In pancreatic cancer cells, AF6 is expressed at reduced levels, causing Dvl2 (show DVL2 Antibodies) to be upregulated and available to bind and enhance FOXE1 (show FOXE1 Antibodies)-induced trans-activation of Snail (show SNAI1 Antibodies), which promotes proliferation and metastasis.

  2. AF-6/afadin could be a useful selection marker for fertility-sparing therapy for patients with atypical hyperplasia or grade 1 endometrioid adenocarcinoma with no myometrial invasion.

  3. JAM-A (show F11R Antibodies) regulates epithelial permeability via association with ZO-2 (show TJP2 Antibodies), afadin, and PDZ-GEF1 (show RAPGEF2 Antibodies) to activate Rap2c (show RAP2C Antibodies) and control contraction of the apical cytoskeleton.

  4. MLL (show MLL Antibodies)-AF6 oncoprotein potentiates the activity of the RAS pathway through retention of AF6 within the nucleus.

  5. The expression levels of CFTR (show CFTR Antibodies) and AF-6/afadin are significantly downregulated in human colon cancer tissues.

  6. AF-6 is a positive modulator of the PINK1 (show PINK1 Antibodies)/parkin (show PARK2 Antibodies) pathway and is deficient in Parkinson's disease.

  7. The interaction between the PDZ domain (show INADL Antibodies) of afadin (AF6_PDZ) and a series of polypeptides comprising the PDZ (show INADL Antibodies)-binding motif, was studied.

  8. Results demonstrate a role for afadin in the regulation of vascular barrier function via coordination of adherens junction-tight junction and p120-catenin (show CTNND1 Antibodies)-ZO-1 (show TJP1 Antibodies) interactions.

  9. the Necl-5 (show PVR Antibodies)-nectin (show PVRL1 Antibodies), nectin-nectin (show PVRL1 Antibodies), and nectin (show PVRL1 Antibodies)-afadin interactions cooperatively increase the clustering of the nectin (show PVRL1 Antibodies)-afadin complex at the cell-cell contact sites, promoting the formation of the nectin (show PVRL1 Antibodies)-based cell-cell adhesion.

  10. AF6/afadin is a marker of poor outcome in breast cancer, and its loss induces cell migration, invasiveness and tumor growth

Mouse (Murine) Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 4 (MLLT4) interaction partners

  1. Results indicate that afadin is required for the maintenance of the radial glial scaffold for neuronal migration and that the genetic ablation of afadin leads to the formation of double cortex

  2. Here, the first crystal structure of the AFPDZ in complex with the nectin-3 (show PVRL3 Antibodies) C-terminal peptide containing the class II motif is reported.

  3. Afadin plays a role in the restricted localization of Paneth cells at the base of the crypt by maintaining their adhesion to adjacent crypt cells and inhibiting their movement toward the top of villi.

  4. S-afadin-specific C-terminal inserts may be involved in its preference of binding to nectin-3 (show PVRL3 Antibodies) and raise the possibility that there are proteins other than nectins that more preferentially bind s-afadin than l-afadin.

  5. A remarkable function of afadin was revealed, it was able to enhance cytokine expression through Rap1 activation in keratinocytes during inflammation.

  6. Afadin regulates puncta adherentia junction formation and presynaptic differentiation in hippocampal neurons.

  7. This study showed that the adherens junction proteins afadin and CDH2 (show CDH2 Antibodies) are critical for the control of cell proliferation in the dorsal telencephalon and for the formation of its normal laminar structure. Inactivation.

  8. Genetic deletion of afadin causes hydrocephalus by destruction of adherens junctions in radial glial and ependymal cells in the midbrain.

  9. Results indicate that PLEKHA7 (show PLEKHA7 Antibodies) plays a cooperative role with nectin (show PVRL1 Antibodies) and afadin in the proper formation of Adherens junction (AJ) in epithelial cell.

  10. Afadin acts upstream of the Par (show AFG3L2 Antibodies) complex to regulate the integration and/or coalescence of membrane microdomains, establishing apical-basal polarity and lumen formation/elongation during kidney tubulogenesis.

Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 4 (MLLT4) Antigen Profile

Protein Summary

This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene, involved in acute myeloid leukemias with t(6\;11)(q27\;q23) translocation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, however, not all have been fully characterized.

Gene names and symbols associated with MLLT4

  • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 (MLLT4) antibody
  • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 4 (mllt4) antibody
  • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 (mllt4) antibody
  • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 (Mllt4) antibody
  • 5033403D15Rik antibody
  • Af-6 antibody
  • Af6 antibody
  • Afadin antibody
  • Gm314 antibody
  • I-afadin antibody
  • MLLT4 antibody
  • RP3-431P23.3 antibody
  • S-afadin antibody
  • si:ch211-278j12.1 antibody

Protein level used designations for MLLT4

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 , afadin-like , ALL1-fused gene from chromosome 6 protein , afadin , protein AF-6 , myeloid/lymphoid or mixed lineage-leukemia translocation to 4 homolog , protein Af-6 , myeloid/lymphoid or mixed-lineage leukemia 4

GENE ID SPECIES
421564 Gallus gallus
463135 Pan troglodytes
496308 Xenopus laevis
558359 Danio rerio
589923 Strongylocentrotus purpuratus
693560 Macaca mulatta
100054846 Equus caballus
100177180 Ciona intestinalis
100493083 Xenopus (Silurana) tropicalis
100546394 Meleagris gallopavo
100564963 Anolis carolinensis
100592208 Nomascus leucogenys
4301 Homo sapiens
17356 Mus musculus
26955 Rattus norvegicus
431695 Canis lupus familiaris
100514741 Sus scrofa
504856 Bos taurus
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