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anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) Antibodies

MLL encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. Additionally we are shipping Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MLL 4297 Q03164
MLL 214162 P55200
Anti-Rat MLL MLL 315606  
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Top anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) Antibodies at antibodies-online.com

Showing 10 out of 89 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated IHC, ELISA, WB Figure 1: Immunohistochemical analysis of paraffin-embedded human lung... Figure 2: Western blot analysis using MLL mouse mAb against truncated ... 100 μL Log in to see 3 to 4 Days
$393.80
Details
Human Rabbit Un-conjugated ChIPSeq, ChIP, ICC, IF, WB MLL / HRX antibody (pAb) tested by ChIP-Seq. ChIP was performed using ... MLL / HRX antibody (pAb) tested by Immunofluorescence. Formaldehyde fi... 100 μg Log in to see 1 to 2 Days
$478.33
Details
Human Mouse Un-conjugated IHC, WB   100 μL Log in to see 10 to 11 Days
$464.29
Details
Human Rabbit Un-conjugated FACS, IHC (p) Formalin-fixed and paraffin-embedded human cancer tissue reacted with ... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated ChIP, IP, WB   100 μg Log in to see 1 to 2 Days
$466.67
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB 100 μL Log in to see 8 to 10 Days
$1,101.83
Details
Human Mouse Un-conjugated EIA, IHC (p), WB 0.1 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, IHC (p) 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Mouse Un-conjugated IHC (p), ELISA, WB 100 μL Log in to see 8 to 10 Days
$676.50
Details

MLL Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human , , , ,
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Mouse (Murine) , , , ,
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Top referenced anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) Antibodies

  1. Human Polyclonal MLL Primary Antibody for EIA, IHC (p) - ABIN356674 : Megonigal, Cheung, Rappaport, Nowell, Wilson, Jones, Addya, Leonard, Kushner, Williams, Lange, Felix: Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors. in Proceedings of the National Academy of Sciences of the United States of America 2000 (PubMed)
    Show all 5 references for ABIN356674

  2. Human Monoclonal MLL Primary Antibody for IHC, WB - ABIN2869284 : Partida-Pérez, Domínguez, Sánchez-Corona, Castañeda-Cisneros, García-González, López-Cardona, Rivera: Constitutional duplication 11q23 de novo involving the MLL gene. in Genetic counseling (Geneva, Switzerland) 2006 (PubMed)
    Show all 4 references for ABIN2869284

  3. Human Monoclonal MLL Primary Antibody for IHC, ELISA - ABIN969286 : Nigro, Sainati, Leszl, Mirabile, Spinelli, Consarino, Di Cataldo, Magro, Felix, Basso: Acute differentiated dendritic cell leukemia: a variant form of pediatric acute myeloid leukemia with MLL translocation. in Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2007 (PubMed)
    Show all 3 references for ABIN969286

  4. Human Polyclonal MLL Primary Antibody for ChIPSeq, ChIP - ABIN2668494 : Ahmad, Katryniok, Scholz, Merkens, Löscher, Marschalek, Steinhilber: Inhibition of class I HDACs abrogates the dominant effect of MLL-AF4 by activation of wild-type MLL. in Oncogenesis 2014 (PubMed)
    Show all 2 references for ABIN2668494

  5. Human Monoclonal MLL Primary Antibody for ChIP, IP - ABIN2668648 : Jin, Zhao, Yi, Nakata, Kalota, Gewirtz: c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis. in The Journal of clinical investigation 2010 (PubMed)

More Antibodies against Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) Interaction Partners

Human Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) interaction partners

  1. MLL1 and DOT1L (show DOT1L Antibodies) cooperate with meningioma-1 to induce acute myeloid leukemia (show BCL11A Antibodies).

  2. Our findings define SON as a fine-tuner of the MLL-menin (show MEN1 Antibodies) interaction and reveal short SON overexpression as a marker indicating aberrant transcriptional initiation in leukemia.

  3. AF4 and AF4-MLL mediate transcriptional elongation of 5-lipoxygenase (show ALOX5 Antibodies) mRNA by 1, 25-dihydroxyvitamin D3.

  4. The results explain how the MLL SET domains of MLL1 and MLL4 (show MLL2 Antibodies) are able to add multiple methyl groups to the target histone H3 (show HIST3H3 Antibodies) lysine.

  5. Identify of MLL-fusion/MYC (show MYC Antibodies) dash, verticalmiR-26 dash, verticalTET1 signaling circuit in MLL-rearranged acute myeloid leukemia (show BCL11A Antibodies).

  6. AEP (show LGMN Antibodies) coactivator complex facilitates the initiation of RNAP2-dependent transcription via SL1 (show MMP3 Antibodies) activity by loading TBP (show TBP Antibodies) onto the TATA element.

  7. findings reveal direct MLL1 epigenetic control over proproliferative cell cycle genes: MLL1 inhibition represses expression of proproliferative cell cycle regulators required for DNA replication and DDR (show DDR1 Antibodies) activation, thus disabling SASP (show ASPRV1 Antibodies) expression.

  8. The Aven (show AVEN Antibodies) RGG/RG motif bound G4 structures within the coding regions of the MLL1 and MLL4 (show MLL2 Antibodies) mRNAs increasing their polysomal association and translation, resulting in the induction of transcription of leukemic genes.

  9. A de novo mutation in KMT2A associated with psychomotor developmental delay.

  10. Set1/MLL complex is indispensable for the transcriptional ability of HSF2.

Mouse (Murine) Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) interaction partners

  1. MLL1 and DOT1L (show DOT1L Antibodies) cooperate with meningioma-1 to induce acute myeloid leukemia (show BCL11A Antibodies).

  2. Set1 (show SETD1A Antibodies) role in cellular reprogramming and its interactions with Dpy30 (show DPY30 Antibodies),Myc (show MYC Antibodies),Sox2 (show SOX2 Antibodies) and Ash2l (show ASH2L Antibodies) reprogramming factors

  3. The present study examined the mechanism underlying the development of KMT2A (MLL)-rearranged infant leukemia in response to in utero exposure to etoposide in a mouse model.

  4. We have demonstrated that the Mll1 gene is critical to Th1 (show HAND1 Antibodies) differentiation in humans and mice

  5. MLL is the key Taspase1 substrate whose cleavage is required for MMTV-neuinduced tumor formation.

  6. Data indicate that Meis homeobox 1 (MEIS1 (show MEIS1 Antibodies)) is required for the maintenance of myeloid-lymphoid leukemia protein MLL-fusion gene leukemia, and hepatic leukemia factor (HLF (show HLF Antibodies))is a key downstream mediator of Meis1 (show MEIS1 Antibodies).

  7. Using a PDK1 (show PDPK1 Antibodies) conditional deletion MLL-AF9 (show MLLT3 Antibodies) murine AML (show RUNX1 Antibodies) model, we revealed that the deletion of PDK1 (show PDPK1 Antibodies) prolonged the survival of AML (show RUNX1 Antibodies) mice by inducing LSC (show ARHGEF1 Antibodies) apoptosis

  8. Recruited MOF (show KAT8 Antibodies) activity, and not the intrinsic HMT (show HNMT Antibodies) activity of MLL1, is central for the maintenance of HSC (show FUT1 Antibodies) target genes. In addition, this work reveals a role for SIRT1 (show SIRT1 Antibodies) in opposing MLL1 function.

  9. Mouse and human cell/xenograft systems have been generated and used to understand how MLL-R (MLL1-1 rearrangement) alleles affect diverse pathways to result in a highly penetrant, drug-resistant leukemia. Review.

  10. MLL1 functions as a coactivator of HSF1 (show HSF1 Antibodies) in response to HSP90 (show HSP90 Antibodies) inhibition

Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) Antigen Profile

Protein Summary

This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with MLL

  • lysine (K)-specific methyltransferase 2A (KMT2A) antibody
  • lysine (K)-specific methyltransferase 2A (Kmt2a) antibody
  • 6430520K01 antibody
  • ALL-1 antibody
  • All1 antibody
  • Cxxc7 antibody
  • HRX antibody
  • HTRX1 antibody
  • mKIAA4050 antibody
  • Mll antibody
  • MLL/GAS7 antibody
  • Mll1 antibody
  • MLL1A antibody
  • TET1-MLL antibody
  • TRX1 antibody
  • WDSTS antibody

Protein level used designations for MLL

CDK6/MLL fusion protein , CXXC-type zinc finger protein 7 , MLL-AF4 der(11) fusion protein , MLL/GAS7 fusion protein , MLL/GMPS fusion protein , histone-lysine N-methyltransferase 2A , lysine N-methyltransferase 2A , myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) , myeloid/lymphoid or mixed-lineage leukemia protein 1 , trithorax-like protein , zinc finger protein HRX , histone-lysine N-methyltransferase MLL , myeloid/lymphoid or mixed-lineage leukemia 1 , trithorax Drosophila , Mixed-lineage leukemia (also acute lymphocytic leukemia 1 or tritorax Drosophila gene)

GENE ID SPECIES
4297 Homo sapiens
214162 Mus musculus
315606 Rattus norvegicus
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