You are viewing an incomplete version of our website. Please click to reload the website as full version.

Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) Proteins (MLL)

MLL encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. Additionally we are shipping Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) Antibodies (89) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MLL 4297 Q03164
MLL 214162 P55200
Rat MLL MLL 315606  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Human GST tag Recombinant MLL / HRX - SET protein gel. MLL / HRX - SET protein was run on a 10% SDS-PAGE gel and stained with Coomassie blue. 20 μg Log in to see 1 to 2 Days
$460.83
Details

MLL Proteins by Origin and Source

Origin Expressed in Conjugate
Human
,
Mouse (Murine)

More Proteins for Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) Interaction Partners

Human Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) interaction partners

  1. Study shows that MLL-AF9 (show MLLT3 Proteins) influences gene expression involved in cell cycle, Wnt (show WNT2 Proteins) signaling, the cellular response to stress, adhesion as well as myeloid differentiation via miRNA expression.

  2. Data show that lysine-specific demethylase 1 (LSD1 (show KDM1A Proteins)) is a drug target for mixed lineage leukemia (MLL)-rearranged leukemia, and LSD1 (show KDM1A Proteins) inhibitors are potential therapeutics for the malignancy.

  3. Data show that basal-like subgroup was enriched for aggressive tumors and somatic mutations in trithorax (show MLLT1 Proteins)-group genes and it overexpressed polycomb (show CBX2 Proteins) genes EZH2 (show EZH2 Proteins) and CBX2 (show CBX2 Proteins).

  4. MLL1 and DOT1L (show DOT1L Proteins) cooperate with meningioma-1 to induce acute myeloid leukemia (show BCL11A Proteins).

  5. Our findings define SON as a fine-tuner of the MLL-menin (show MEN1 Proteins) interaction and reveal short SON overexpression as a marker indicating aberrant transcriptional initiation in leukemia.

  6. AF4 and AF4-MLL mediate transcriptional elongation of 5-lipoxygenase (show ALOX5 Proteins) mRNA by 1, 25-dihydroxyvitamin D3.

  7. The results explain how the MLL SET domains of MLL1 and MLL4 are able to add multiple methyl groups to the target histone H3 (show HIST3H3 Proteins) lysine.

  8. Identify of MLL-fusion/MYC (show MYC Proteins) dash, verticalmiR-26 dash, verticalTET1 signaling circuit in MLL-rearranged acute myeloid leukemia (show BCL11A Proteins).

  9. AEP (show LGMN Proteins) coactivator complex facilitates the initiation of RNAP2-dependent transcription via SL1 (show MMP3 Proteins) activity by loading TBP (show TBP Proteins) onto the TATA element.

  10. findings reveal direct MLL1 epigenetic control over proproliferative cell cycle genes: MLL1 inhibition represses expression of proproliferative cell cycle regulators required for DNA replication and DDR (show DDR1 Proteins) activation, thus disabling SASP (show ASPRV1 Proteins) expression.

Mouse (Murine) Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) interaction partners

  1. Data suggest that RAS-homolog enriched in brain protein (Rheb1) promotes MLL-AF9 fusion protein initiated acute myeloid leukemia (AML) progression through target of rapamycin complex 1 (mTORC1) signaling pathway.

  2. HoxBlinc RNA Recruits Set1/MLL Complexes to Activate Hox (show MSH2 Proteins) Gene Expression Patterns and Mesoderm Lineage Development.

  3. MLL1 and DOT1L (show DOT1L Proteins) cooperate with meningioma-1 to induce acute myeloid leukemia (show BCL11A Proteins).

  4. Set1 role in cellular reprogramming and its interactions with Dpy30 (show DPY30 Proteins),Myc (show MYC Proteins),Sox2 (show SOX2 Proteins) and Ash2l (show ASH2L Proteins) reprogramming factors

  5. The present study examined the mechanism underlying the development of KMT2A (MLL)-rearranged infant leukemia in response to in utero exposure to etoposide in a mouse model.

  6. We have demonstrated that the Mll1 gene is critical to Th1 (show HAND1 Proteins) differentiation in humans and mice

  7. MLL is the key Taspase1 substrate whose cleavage is required for MMTV-neuinduced tumor formation.

  8. Data indicate that Meis homeobox 1 (MEIS1 (show MEIS1 Proteins)) is required for the maintenance of myeloid-lymphoid leukemia protein MLL-fusion gene leukemia, and hepatic leukemia factor (HLF (show HLF Proteins))is a key downstream mediator of Meis1 (show MEIS1 Proteins).

  9. Using a PDK1 (show PDPK1 Proteins) conditional deletion MLL-AF9 (show MLLT3 Proteins) murine AML (show RUNX1 Proteins) model, we revealed that the deletion of PDK1 (show PDPK1 Proteins) prolonged the survival of AML (show RUNX1 Proteins) mice by inducing LSC (show ARHGEF1 Proteins) apoptosis

  10. Recruited MOF (show KAT8 Proteins) activity, and not the intrinsic HMT (show HNMT Proteins) activity of MLL1, is central for the maintenance of HSC (show FUT1 Proteins) target genes. In addition, this work reveals a role for SIRT1 (show SIRT1 Proteins) in opposing MLL1 function.

Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) Protein Profile

Protein Summary

This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with MLL

  • lysine (K)-specific methyltransferase 2A (KMT2A)
  • lysine (K)-specific methyltransferase 2A (Kmt2a)
  • 6430520K01 protein
  • ALL-1 protein
  • All1 protein
  • Cxxc7 protein
  • HRX protein
  • HTRX1 protein
  • mKIAA4050 protein
  • Mll protein
  • MLL/GAS7 protein
  • Mll1 protein
  • MLL1A protein
  • TET1-MLL protein
  • TRX1 protein
  • WDSTS protein

Protein level used designations for MLL

CDK6/MLL fusion protein , CXXC-type zinc finger protein 7 , MLL-AF4 der(11) fusion protein , MLL/GAS7 fusion protein , MLL/GMPS fusion protein , histone-lysine N-methyltransferase 2A , lysine N-methyltransferase 2A , myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) , myeloid/lymphoid or mixed-lineage leukemia protein 1 , trithorax-like protein , zinc finger protein HRX , histone-lysine N-methyltransferase MLL , myeloid/lymphoid or mixed-lineage leukemia 1 , trithorax Drosophila , Mixed-lineage leukemia (also acute lymphocytic leukemia 1 or tritorax Drosophila gene)

GENE ID SPECIES
4297 Homo sapiens
214162 Mus musculus
315606 Rattus norvegicus
Selected quality suppliers for Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) Proteins (MLL)
Did you look for something else?