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anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 (MLL2) Antibodies

The protein encoded by MLL2 is a histone methyltransferase that methylates the Lys-4 position of histone H3. Additionally we are shipping Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 Kits (20) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
Anti-Rat MLL2 MLL2 27100 Q63042
MLL2 9757 Q9UMN6
MLL2 381022  
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Top anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 Antibodies at antibodies-online.com

Showing 10 out of 37 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Goat Un-conjugated IHC, ELISA, WB (4µg/ml) staining of paraffin embedded Human Placenta. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (36.74 KDa) . 100 μg Log in to see 9 Days
$430.00
Details
Human Goat Un-conjugated IHC, ELISA 0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Human Goat Un-conjugated IHC (p), ELISA 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Goat Un-conjugated EIA, IHC (p) AP32078PU-N MLL2 Antibody staining of paraffin embedded Human Liver at 3.8 µg/ml. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining. AP32078PU-N MLL2 Antibody staining of paraffin embedded Human Placenta at 4 µg/ml. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining. 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated ELISA   100 μg Log in to see 8 to 10 Days
$405.17
Details
Human Rabbit Alkaline Phosphatase (AP) ELISA   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Un-conjugated ELISA   100 μL Log in to see 8 to 10 Days
$383.17
Details
Human Rabbit Un-conjugated ELISA   200 μL Log in to see 8 to 10 Days
$713.17
Details
Human Rabbit HRP ELISA   200 μL Log in to see 8 to 10 Days
$969.83
Details

MLL2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , , ,
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Mouse (Murine)


Top referenced anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 Antibodies

  1. Human Polyclonal MLL2 Primary Antibody for IHC, ELISA - ABIN184880 : Prasad, Zhadanov, Sedkov, Bullrich, Druck, Rallapalli, Yano, Alder, Croce, Huebner, Mazo, Canaani: Structure and expression pattern of human ALR, a novel gene with strong homology to ALL-1 involved in acute leukemia and to Drosophila trithorax. in Oncogene 1997 (PubMed)

  2. Human Monoclonal MLL2 Primary Antibody for ELISA, WB - ABIN948660 : Micale, Augello, Maffeo, Selicorni, Zucchetti, Fusco, De Nittis, Pellico, Mandriani, Fischetto, Boccone, Silengo, Biamino, Perria, Sotgiu, Serra, Lapi, Neri, Ferlini, Cavaliere, Chiurazzi, Monica et al.: Molecular analysis, pathogenic mechanisms, and readthrough therapy on a large cohort of Kabuki syndrome patients. ... in Human mutation 2014 (PubMed)

More Antibodies against Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 Interaction Partners

Human Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 (MLL2) interaction partners

  1. Although enhancer priming by MLL4/KMT2D is dispensable for cell-identity maintenance in mouse, it controls cell fate transition by orchestrating p300-mediated enhancer (show EP300 Antibodies)activation

  2. Our data suggest that MLL2 protein is overexpressed in primary gastrointestinal diffuse large B cell lymphoma and appears as a prognostic factor

  3. The results explain how the MLL (show MLL Antibodies) SET domains of MLL1 and MLL4 are able to add multiple methyl groups to the target histone H3 (show HIST3H3 Antibodies) lysine.

  4. The results do not support our hypothesis that common germline genetic variants in the MLL2 genes is associated with the risk of developing medulloblastoma.

  5. Mutations in KMT2D gene is associated with cutaneous T cell lymphoma and Sezary syndrome.

  6. Kabuki syndrome may be caused by mutations in one of two histone methyltransferase genes: KMT2D and KDM6A (show KDM6A Antibodies).

  7. The Aven (show AVEN Antibodies) RGG/RG motif bound G4 structures within the coding regions of the MLL1 and MLL4 mRNAs increasing their polysomal association and translation, resulting in the induction of transcription of leukemic genes.

  8. In patients with Kabuki Syndrome, autosomal dominant KMT2D mutations are associated with dysregulation of terminal B-cell differentiation, leading to humoral immune deficiency and, in some cases, autoimmunity.

  9. Our results provide further support for the similar roles of KMT2D and KDM6A (show KDM6A Antibodies) in the etiology of KS by using a vertebrate model organism to provide direct evidence of their roles in the development of organs and tissues affected in KS patients.

  10. KMT2D represents a recurrently mutated gene with potential implication for pheochromocytoma development.

Mouse (Murine) Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 (MLL2) interaction partners

  1. Although enhancer priming by H3K4me1/2 methyltransferase MLL4/KMT2D is dispensable for cell-identity maintenance, it controls cell fate transition by orchestrating p300 (show NOTCH1 Antibodies)-mediated enhancer activation

  2. KMT2D is essential for regulating cardiac gene expression during heart development primarily via H3K4 di-methylation

  3. MLL2 interacts with RNA polymerase II (RNAPII) and RECQL5, and, although MLL2 mutated cells have normal overall H3K4me levels in genes, nucleosomes in the immediate vicinity of RNAPII are hypomethylated.

  4. MLL4 (KMT2D) is a major H3K4 mono- and di-methyltransferase with partial functional redundancy with MLL3 (KMT2C) in mouse and human cells. MLL4 is enriched on enhancers and is required for enhancer activation, cell-type-specific gene expression and cell differentiation.

  5. Both MLL3 and MLL4 (show MLL4 Antibodies) complexes act as major epigenetic regulators of diverse metabolic processes (including circadian control of bile acid homeostasis).

  6. Mll2 (show MLL4 Antibodies), one of the six Set1 (show SETD1A Antibodies)/Trithorax (show MLLT1 Antibodies)-type H3K4 methyltransferases in mammals, is required for trimethylation of bivalent promoters in mouse embryonic stem cells, whereas Mll1 is redundant.

  7. results demonstrate that histone H3K4 methyltransferase Mll2 (show MLL4 Antibodies) is a component of the genetic regulation necessary for glucose homeostasis, resulting in a specific disease pattern linking chromatin modification with causes and progression of type 2 diabetes

  8. Reexpression of KMT2B (show MLL4 Antibodies) was sufficient to reinstate an active MagohB (show MAGOHB Antibodies) promoter.

  9. Arginine methylation of Pax7 (show PAX7 Antibodies) by Carm1 (show CARM1 Antibodies) functions as a molecular switch controlling the epigenetic induction of Myf5 (show MYF5 Antibodies) during satellite stem cell asymmetric division and entry into the myogenic program.

  10. Here we show that the histone 3 lysine 4 (H3K4) methyltransferase, MLL2 (show MLL4 Antibodies), controls most of the promoter-specific chromatin modification, H3K4me3, during oogenesis and early development.

Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 (MLL2) Antigen Profile

Protein Summary

The protein encoded by this gene is a histone methyltransferase that methylates the Lys-4 position of histone H3. The encoded protein is part of a large protein complex called ASCOM, which has been shown to be a transcriptional regulator of the beta-globin and estrogen receptor genes. Mutations in this gene have been shown to be a cause of Kabuki syndrome.

Gene names and symbols associated with MLL2

  • lysine (K)-specific methyltransferase 2D (kmt2d) antibody
  • glutathione S-transferase omega-1-like (LOC785216) antibody
  • growth factor, augmenter of liver regeneration (Gfer) antibody
  • lysine (K)-specific methyltransferase 2B (KMT2B) antibody
  • lysine (K)-specific methyltransferase 2D (Kmt2d) antibody
  • lysine (K)-specific methyltransferase 2D (KMT2D) antibody
  • myeloid/lymphoid or mixed-lineage leukemia 2 (MLL2) antibody
  • myeloid/lymphoid or mixed-lineage leukemia 2-like (Mll2l) antibody
  • AAD10 antibody
  • ALR antibody
  • BC032281 antibody
  • BC058659 antibody
  • C430014K11Rik antibody
  • CAGL114 antibody
  • GSTO1 antibody
  • HRX2 antibody
  • im:7157663 antibody
  • KABUK1 antibody
  • KMS antibody
  • KMT2B antibody
  • MLL1B antibody
  • Mll2 antibody
  • Mll4 antibody
  • TNRC21 antibody
  • TRX2 antibody
  • WBP7 antibody

Protein level used designations for MLL2

myeloid/lymphoid or mixed-lineage leukemia 2 , glutathione S-transferase omega 1 , FAD-linked sulfhydryl oxidase ALR , augmenter of liver regeneration , growth factor, erv1 homolog , growth factor, erv1-like (augmenter of liver regeneration) , KMT2D , WBP-7 , WW domain binding protein 7 , WW domain-binding protein 7 , histone-lysine N-methyltransferase 2B , histone-lysine N-methyltransferase MLL4 , lysine N-methyltransferase 2B , lysine N-methyltransferase 2D , mixed lineage leukemia gene homolog 2 , myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 4 , myeloid/lymphoid or mixed-lineage leukemia 4 , myeloid/lymphoid or mixed-lineage leukemia protein 4 , trithorax homolog 2 , trithorax homologue 2 , ALL1-related protein , histone-lysine N-methyltransferase 2D , histone-lysine N-methyltransferase MLL2 , myeloid/lymphoid or mixed-lineage leukemia protein 2 , Kabuki make-up syndrome , Kabuki mental retardation syndrome , trinucleotide repeat containing 21

GENE ID SPECIES
100158249 Danio rerio
785216 Bos taurus
27100 Rattus norvegicus
9757 Homo sapiens
381022 Mus musculus
8085 Homo sapiens
506805 Bos taurus
100512962 Sus scrofa
486558 Canis lupus familiaris
425846 Gallus gallus
362996 Rattus norvegicus
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