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Capable of activating transcription from synthetic reporter genes in both lymphoid and myeloid cells.. Additionally we are shipping MLLT1 Antibodies (41) and many more products for this protein.
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data identify ENL as a histone acetylation reader that regulates oncogenic transcriptional programs in acute myeloid leukaemia, and suggest that displacement of ENL from chromatin may be a promising epigenetic therapy, alone or in combination with BET inhibitors, for aggressive leukaemia
MLL (show MLL Proteins)-ENL dysregulated the proliferative and repopulating capacity of hematopoietic stem cells.
Recurrent mutations within Wilms tumours involve the highly conserved YEATS domain of MLLT1.
Novel splice isoform of Mllt1 is documented and confirmed that both Mllt1 mRNA isoforms are translated. The data support that MLLT1 protein isoforms display distinct stage-specific expression during spermiogenesis and adult tissues.
Data suggest that AT mutated protein ATM (show ATM Proteins)-dependent phosphorylation of ENL (MLLT1) protein functions as switch from elongation to Polycomb (show CBX2 Proteins)-mediated repression to preserve genome integrity.
AF9 and its homolog ENL directly interact with AF4.
MLL (show MLL Proteins)-ENL Interaction with CBX8 (show CBX8 Proteins) Is Required for Efficient Transformation.
Data from a follow-up study in Rome suggest a particularly favorable prognosis for patients with acute lymphoblastic leukemia expressing the MLL (show MLL Proteins)/ENL fusion gene.
Three-way translocation involving MLL (show MLL Proteins), MLLT1, and a novel third partner, NRXN1 (show NRXN1 Proteins), in a patient with acute lymphoblastic leukemia and t(2;19;11) (p12 (show POLE4 Proteins);p13.3;q23).
ENL chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner.
define a specific pairing of two amino acids that creates a salt bridge between MLLT1/3 and AFF proteins that is critically important for MLL (show MLL Proteins)-mediated transformation of HPCs
demonstrate BAM11 transcriptional co-activation activity and its functional interaction with Btk (show BTK Proteins)
An intimate association between MLL (show MLL Proteins) and RNA pol II (show POLR2F Proteins) occurs at MLL (show MLL Proteins) target genes in vivo that is required for normal initiation and/or transcriptional elongation.
Overlapping expression of Af9 (show MLLT3 Proteins) with Af4/Aff1 and Fmr2/Aff2 (show AFF2 Proteins), two genes that are also related to neurodevelopmental diseases, as well as with the highly homologous Enl.
Even genetically complex leukemias can be reversed on inactivation of the initiating MLL (show MLL Proteins) fusion.
Capable of activating transcription from synthetic reporter genes in both lymphoid and myeloid cells.
myeloid/lymphoid or mixed lineage leukemia translocation to 1 homolog
, myeloid/lymphoid or mixed lineage-leukemia translocation to 1 homolog
, protein ENL
, myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
, myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 1
, ENL/MLL fusion
, MLLT1/MLL fusion
, YEATS domain-containing protein 1
, leukemia-associated protein MLLT1
, myeloid/lymphoid or mixed lineage-leukemia translocation to 4 homolog