anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 (MLLT3) Antibodies

mouse homolog regulates pattern formation during embryogenesis. Additionally we are shipping Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MLLT3 4300 P42568
MLLT3 70122 A2AM29
MLLT3 114510  
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Top anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 Antibodies at antibodies-online.com

Showing 10 out of 84 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-MLLT3 Antibody Titration: </b>0.2-1 ug/ml<br><b>Positive Control: </b>HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-MLLT3 Antibody Titration: </b>0.2-1 ug/ml<br><b>Positive Control: </b>HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB The anti-MLLT3 Pab (ABIN390129) is used in Western blot to detect MLLT3 in mouse cerebellum tissue lysate MLLT3 Antibody (C-term) (ABIN390129) western blot analysis in 293 cell line lysates (35 µg/lane).This demonstrates the MLLT3 antibody detected the MLLT3 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of AF9 (MLLT3) Antibody (C-term K486) (ABIN390128) in 293 cell line lysates (35 µg/lane). MLLT3(arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), IP, WB Detection of Human AF9 by Western Blot and Immunoprecipitation. Samples: Whole cell lysate (5, 10 and 50 mcg for WB, 1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-AF9 antibody ABIN151110 used for WB at 0.1 mcg/ml (A) and 1 mcg/ml (B), and used for IP at 3 mcg/mg lysate. AF9 was also immunoprecipitated using rabbit anti-AF9 antibodies ABIN151108, ABIN151109 and another AF9 Ab at 3 mcg/mg lysate. Detection: Chemiluminescence with exposure times of 30 seconds (A and B). 100 μL Log in to see 7 to 9 Days
$486.94
Details
Cow Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated WB The anti-MLLT3 Pab (ABIN390130) is used in Western blot to detect MLLT3 in HL60 tissue lysate 400 μL Log in to see 10 to 11 Days
$324.50
Details

MLLT3 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , ,
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Mouse (Murine)


Rat (Rattus)


Top referenced anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 Antibodies

  1. Human Polyclonal MLLT3 Primary Antibody for ICC, IF - ABIN151110 : Lin, Hemenway: Hsp90 directly modulates the spatial distribution of AF9/MLLT3 and affects target gene expression. in The Journal of biological chemistry 2010 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal MLLT3 Primary Antibody for IHC (p), WB - ABIN390128 : Iida, Seto, Yamamoto, Komatsu, Tojo, Asano, Kamada, Ariyoshi, Takahashi, Ueda: MLLT3 gene on 9p22 involved in t(9;11) leukemia encodes a serine/proline rich protein homologous to MLLT1 on 19p13. in Oncogene 1993 (PubMed)
    Show all 5 Pubmed References

  3. Human Polyclonal MLLT3 Primary Antibody for EIA, IHC (p) - ABIN358673 : Bitoun, Oliver, Davies: The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling. in Human molecular genetics 2007 (PubMed)
    Show all 2 Pubmed References

More Antibodies against Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 Interaction Partners

Human Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 (MLLT3) interaction partners

  1. MLL (show MLL Antibodies)-AF9 fusion is associated with acute myeloid leukemia (show BCL11A Antibodies).

  2. Structural insights into H3 histone (show HIST1H3B Antibodies) crotonyl-lysine recognition by the AF9 YEATS domain have been presented.

  3. A luciferase reporter gene assay revealed that hsp70 promoter activation is enhanced by the transcriptional co-activator AF9 and splicing mediator SNRPE, but suppressed by the coiled-coil domain-containing protein CCDC127.

  4. YEATS domain of AF9 directly links histone crotonylation to active transcription.

  5. Results show that human MLL (show MLL Antibodies)-AF9 expression in mouse long-term hematopoietic stem cells causes invasive, chemoresistant acute myeloid leukemia (show BCL11A Antibodies) that expresses genes related to epithelial-mesenchymal transition.

  6. Results show that MLL (show MLL Antibodies)-AF9 reduces Id2 and increases E2-2 (show TCF4 Antibodies) expression to drive and sustain leukemia stem cell potential in MLL (show MLL Antibodies)-rearranged acute myeloid leukemia (show BCL11A Antibodies) (AML (show RUNX1 Antibodies)). Low expression of Id2 or of an Id2 gene signature is associated with poor prognosis in not only MLL (show MLL Antibodies)-rearranged but also t(8;21) AML (show RUNX1 Antibodies) patients.

  7. Exploring the mechanism how AF9 recognizes and binds H3K9ac by molecular dynamics simulations and free energy calculations.

  8. Studies identified the evolutionarily conserved Af9 YEATS domain as a novel acetyllysine-binding module and established a direct link between histone acetylation and DOT1L (show DOT1L Antibodies)-mediated H3K79 methylation in transcription control.

  9. AF9 and its homolog ENL directly interact with AF4.

  10. Abrogation of Rac1 signaling causes DNA double-strand breaks in acute monocytic leukemia (show KAT6B Antibodies) cells harbouring the MLL (show MLL Antibodies)-AF9 oncogene (show RAB1A Antibodies).

Mouse (Murine) Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 (MLLT3) interaction partners

  1. Atg5 (show ATG5 Antibodies)-dependent autophagy contributes to the development of acute myeloid leukemia (show BCL11A Antibodies) in an MLL (show MLL Antibodies)-AF9-driven mouse model.

  2. YEATS domain of AF9 directly links histone crotonylation to active transcription.

  3. Data suggest that RAS-homolog enriched in brain protein (Rheb1) promotes MLL-AF9 fusion protein initiated acute myeloid leukemia (AML) progression through target of rapamycin complex 1 (mTORC1) signaling pathway.

  4. Using a PDK1 (show PDPK1 Antibodies) conditional deletion MLL (show MLL Antibodies)-AF9 murine AML (show RUNX1 Antibodies) model, we revealed that the deletion of PDK1 (show PDPK1 Antibodies) prolonged the survival of AML (show RUNX1 Antibodies) mice by inducing LSC (show ARHGEF1 Antibodies) apoptosis

  5. define a specific pairing of two amino acids that creates a salt bridge between MLLT1 (show MLLT1 Antibodies)/3 and AFF proteins that is critically important for MLL (show MLL Antibodies)-mediated transformation of HPCs

  6. Af9 mediates site-selective physical and functional recruitment of Rnf2 (show RNF2 Antibodies) to the alpha-ENaC (show SCNN1A Antibodies) promoter to constrain basal alpha-ENaC (show SCNN1A Antibodies) transcription in collecting duct cells.

  7. Impaired alphaENaC (show SCNN1A Antibodies) expression due to failure to inhibit Dot1a-Af9 may play an important role in the early stages of pseudohypoaldosteronism type 1 in MR(-/-) mice.

  8. We demonstrate that leukemogenic activity of MLL (show MLL Antibodies)-AF9 requires RUVBL2 (RuvB-like 2 (show RUVBL2 Antibodies)), an AAA (show AAAS Antibodies)+ ATPase (show DNAH8 Antibodies) family member that functions in a wide range of cellular processes, including chromatin remodeling and transcriptional regulation.

  9. Therefore, Dot1a and Af9 as aldosterone-downregulated targets are negative regulators of endothelin-1 (show EDN1 Antibodies) transcription in vitro and in vivo, and may be considered as new potential therapeutic targets of kidney injury in diabetes.

  10. It was concluded that +78/+92 of the epithelial Na+ channel alpha (show SCNN1A Antibodies)-subunit (show POLG Antibodies) represents the primary Af9 binding site involved in recruiting Dot1a to repress basal and aldosterone-sensitive Na+ channel alpha-subunit (show POLG Antibodies) transcription.

Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 (MLLT3) Antigen Profile

Protein Summary

mouse homolog regulates pattern formation during embryogenesis

Gene names and symbols associated with MLLT3

  • myeloid/lymphoid or mixed lineage-leukemia translocation to 3 homolog (Drosophila) (mllt3) antibody
  • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 (MLLT3) antibody
  • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 (Mllt3) antibody
  • 2210011H10Rik antibody
  • 2610012I03Rik antibody
  • 3830408D16Rik antibody
  • Af-9 antibody
  • Af9 antibody
  • D4Ertd321e antibody
  • fc39c11 antibody
  • wu:fc39c11 antibody
  • YEATS3 antibody
  • zgc:110210 antibody

Protein level used designations for MLLT3

protein AF-9 , ALL1-fused gene from chromosome 9 protein , YEATS domain-containing protein 3 , myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 3 , myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein , myeloid/lymphoid or mixed lineage-leukemia translocation to 3 homolog , myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein homolog , myeloid/lymphoid or mixed-lineage leukemia, translocated to, 3 , myeloid/lymphoid or mixed-lineage leukemia,translocated to, 3 (trithorax homolog, Drosophila) , translocated to, 3

GENE ID SPECIES
550517 Danio rerio
4300 Homo sapiens
521962 Bos taurus
70122 Mus musculus
481556 Canis lupus familiaris
114510 Rattus norvegicus
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