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anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) Antibodies

MLL encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. Additionally we are shipping Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MLL 4297 Q03164
MLL 214162 P55200
MLL 315606  
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Top anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) Antibodies at antibodies-online.com

Showing 10 out of 49 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated IHC, ELISA, WB Figure 1: Immunohistochemical analysis of paraffin-embedded human lung cancer (left) and esophagus cancer (right), showing nuclear weak staining with DAB staining using MLL mouse mAb. Figure 2: Western blot analysis using MLL mouse mAb against truncated MLL recombinant protein (1) and truncated GFP-MLL (aa3714-3969) transfected Cos7 cell lysate (2) . 100 μL Log in to see 3 to 4 Days
$393.80
Details
Human Mouse Un-conjugated ELISA, IHC, WB   100 μL Log in to see 10 to 11 Days
$464.29
Details
Human Rabbit Un-conjugated ChIPSeq, ChIP, ICC, IF, WB MLL / HRX antibody (pAb) tested by ChIP-Seq. ChIP was performed using the ChIP-IT® High Sensitivity Kit (Cat. No. 53040) with 30 ug of chromatin from HeLa cells and 4 µg of antibody. ChIP DNA was sequenced on the Illumina HiSeq and 20 million sequence tags were mapped to identify MLL / HRX binding sites. The image shows binding across a region of chromosome 12. You can view the complete data set in the UCSC Genome Browser, starting at this specific location, here. MLL / HRX antibody (pAb) tested by Immunofluorescence. Formaldehyde fixed HeLa cells stained with MLL / HRX antibody at a 0.5 µg/ml dilution. 100 μg Log in to see 1 to 2 Days
$507.50
Details
Human Rabbit Un-conjugated FACS, IHC (p) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated EIA, IHC (p), WB 0.1 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated ChIP, IP, WB   100 μg Log in to see 1 to 2 Days
$495.83
Details
Human Rabbit Un-conjugated EIA, IHC (p) 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Mouse Un-conjugated IHC, WB 0.1 mL Log in to see 2 to 3 Days
$412.50
Details
Human Rabbit Un-conjugated IHC, ELISA 0.05 mg Log in to see 2 to 3 Days
$515.63
Details

MLL Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Mouse (Murine) ,
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Rat (Rattus)


Top referenced anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) Antibodies

  1. Human Polyclonal MLL Primary Antibody for EIA, IHC (p) - ABIN356674 : Megonigal, Cheung, Rappaport, Nowell, Wilson, Jones, Addya, Leonard, Kushner, Williams, Lange, Felix: Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors. in Proceedings of the National Academy of Sciences of the United States of America 2000 (PubMed)
    Show all 5 references for ABIN356674

  2. Human Monoclonal MLL Primary Antibody for ELISA, IHC - ABIN2869284 : Partida-Pérez, Domínguez, Sánchez-Corona, Castañeda-Cisneros, García-González, López-Cardona, Rivera: Constitutional duplication 11q23 de novo involving the MLL gene. in Genetic counseling (Geneva, Switzerland) 2006 (PubMed)
    Show all 4 references for ABIN2869284

  3. Human Monoclonal MLL Primary Antibody for IHC, ELISA - ABIN969286 : Nigro, Sainati, Leszl, Mirabile, Spinelli, Consarino, Di Cataldo, Magro, Felix, Basso: Acute differentiated dendritic cell leukemia: a variant form of pediatric acute myeloid leukemia with MLL translocation. in Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2007 (PubMed)
    Show all 3 references for ABIN969286

  4. Human Polyclonal MLL Primary Antibody for ChIPSeq, ChIP - ABIN2668494 : Ahmad, Katryniok, Scholz, Merkens, Löscher, Marschalek, Steinhilber: Inhibition of class I HDACs abrogates the dominant effect of MLL-AF4 by activation of wild-type MLL. in Oncogenesis 2014 (PubMed)
    Show all 2 references for ABIN2668494

  5. Human Monoclonal MLL Primary Antibody for ChIP, IP - ABIN2668648 : Jin, Zhao, Yi, Nakata, Kalota, Gewirtz: c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis. in The Journal of clinical investigation 2010 (PubMed)

More Antibodies against Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) Interaction Partners

Human Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) interaction partners

  1. The data revealed the presence of a partial tandem duplication of the MLL gene as the only detectable copy number change and 11 non-silent somatic mutations, including DNMT3A (show DNMT3A Antibodies) R882H and NRAS (show NRAS Antibodies) G13D. All somatic lesions were present both at initial MDS (show PAFAH1B1 Antibodies)/MPN (show PRSS27 Antibodies)-U diagnosis and at AML (show RUNX1 Antibodies) presentation at similar mutant allele frequencies.

  2. KMT2A rearrangement is associated with B-cell lymphoblastic leukemia.

  3. Loss of MLL-AF4 activity results in a reduction of H3K79me3 levels in the gene body and H3K27Ac levels at the 3' BCL-2 (show BCL2 Antibodies) enhancer, revealing a novel regulatory link between these two histone marks and MLL-AF4-mediated activation of BCL-2 (show BCL2 Antibodies).

  4. Results revealed that double minute chromosomes in myeloid neoplasms commonly harbor MYC (show MYC Antibodies) or MLL gene amplification and manifest as micronuclei within leukemic blasts.

  5. Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (show CAPS Antibodies) (WDR5 (show WDR5 Antibodies)) and Mixed Lineage Leukemia (MLL)/SET1 (show SETD1A Antibodies) Family Proteins Specifically Inhibits MLL1 and SETd1A (show SETD1A Antibodies) Methyltransferase Complexes.

  6. miR (show MLXIP Antibodies)-155 levels are correlated with MLL translocations, but that miR (show MLXIP Antibodies)-155 expression is dispensable for the formation of AML (show RUNX1 Antibodies) and has no effect on leukemia progression.

  7. MLL-ENL (show MLLT1 Antibodies) dysregulated the proliferative and repopulating capacity of hematopoietic stem cells.

  8. This review summarizes and discusses the general mechanisms of H3K4 methylation, and how the six main enzymes from the SET/MLL family (responsible for H3K4me1/me2 (show CELSR1 Antibodies)/me3 (show ME3 Antibodies)) function in hematopoiesis and in hematologic malignancies. [review]

  9. Results show that human MLL-AF9 (show MLLT3 Antibodies) expression in mouse long-term hematopoietic stem cells causes invasive, chemoresistant acute myeloid leukemia (show BCL11A Antibodies) that expresses genes related to epithelial-mesenchymal transition.

  10. Authors evaluated the expression levels of the MLL gene in AML (show RUNX1 Antibodies) patients.

Mouse (Murine) Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) interaction partners

  1. Data suggest that RAS-homolog enriched in brain protein (Rheb1) promotes MLL-AF9 fusion protein initiated acute myeloid leukemia (AML) progression through target of rapamycin complex 1 (mTORC1) signaling pathway.

  2. HoxBlinc RNA Recruits Set1 (show SETD1A Antibodies)/MLL Complexes to Activate Hox (show MSH2 Antibodies) Gene Expression Patterns and Mesoderm Lineage Development.

  3. MLL1 and DOT1L (show DOT1L Antibodies) cooperate with meningioma-1 to induce acute myeloid leukemia (show BCL11A Antibodies).

  4. Set1 (show SETD1A Antibodies) role in cellular reprogramming and its interactions with Dpy30 (show DPY30 Antibodies),Myc (show MYC Antibodies),Sox2 (show SOX2 Antibodies) and Ash2l (show ASH2L Antibodies) reprogramming factors

  5. The present study examined the mechanism underlying the development of KMT2A (MLL)-rearranged infant leukemia in response to in utero exposure to etoposide in a mouse model.

  6. We have demonstrated that the Mll1 gene is critical to Th1 (show HAND1 Antibodies) differentiation in humans and mice

  7. MLL is the key Taspase1 substrate whose cleavage is required for MMTV-neuinduced tumor formation.

  8. Data indicate that Meis homeobox 1 (MEIS1 (show MEIS1 Antibodies)) is required for the maintenance of myeloid-lymphoid leukemia protein MLL-fusion gene leukemia, and hepatic leukemia factor (HLF (show HLF Antibodies))is a key downstream mediator of Meis1 (show MEIS1 Antibodies).

  9. Using a PDK1 (show PDPK1 Antibodies) conditional deletion MLL-AF9 (show MLLT3 Antibodies) murine AML (show RUNX1 Antibodies) model, we revealed that the deletion of PDK1 (show PDPK1 Antibodies) prolonged the survival of AML (show RUNX1 Antibodies) mice by inducing LSC (show ARHGEF1 Antibodies) apoptosis

  10. Recruited MOF (show KAT8 Antibodies) activity, and not the intrinsic HMT (show HNMT Antibodies) activity of MLL1, is central for the maintenance of HSC (show FUT1 Antibodies) target genes. In addition, this work reveals a role for SIRT1 (show SIRT1 Antibodies) in opposing MLL1 function.

Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) Antigen Profile

Protein Summary

This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with MLL

  • lysine (K)-specific methyltransferase 2A (KMT2A) antibody
  • lysine (K)-specific methyltransferase 2A (Kmt2a) antibody
  • 6430520K01 antibody
  • ALL-1 antibody
  • All1 antibody
  • Cxxc7 antibody
  • HRX antibody
  • HTRX1 antibody
  • mKIAA4050 antibody
  • Mll antibody
  • MLL/GAS7 antibody
  • Mll1 antibody
  • MLL1A antibody
  • TET1-MLL antibody
  • TRX1 antibody
  • WDSTS antibody

Protein level used designations for MLL

CDK6/MLL fusion protein , CXXC-type zinc finger protein 7 , MLL-AF4 der(11) fusion protein , MLL/GAS7 fusion protein , MLL/GMPS fusion protein , histone-lysine N-methyltransferase 2A , lysine N-methyltransferase 2A , myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) , myeloid/lymphoid or mixed-lineage leukemia protein 1 , trithorax-like protein , zinc finger protein HRX , histone-lysine N-methyltransferase MLL , myeloid/lymphoid or mixed-lineage leukemia 1 , trithorax Drosophila , Mixed-lineage leukemia (also acute lymphocytic leukemia 1 or tritorax Drosophila gene)

GENE ID SPECIES
4297 Homo sapiens
214162 Mus musculus
315606 Rattus norvegicus
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