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Histone methyltransferase that plays an essential role in early development and hematopoiesis. Additionally we are shipping Myeloid/lymphoid Or Mixed-Lineage Leukemia 1 Antibodies (10) and many more products for this protein.
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Epigenomic profiling indicates an abnormal H3K79me2 pattern on MLL (show MLL ELISA Kits)-fusion targeted genes, but the molecular mechanism underlying this epigenetic dependency is not well understood.
NUP98 (show NUP98 ELISA Kits)-HOXA9 (show HOXA9 ELISA Kits) interacts with MLL (show MLL ELISA Kits) via the NUP98 (show NUP98 ELISA Kits) second FG repeat domain. In the absence of MLL (show MLL ELISA Kits) (in knockout mice), NUP98 (show NUP98 ELISA Kits)-HOXA9 (show HOXA9 ELISA Kits)-induced cell immortalization and leukemogenesis are severely inhibited. MLL (show MLL ELISA Kits) is important for the recruitment of NUP98 (show NUP98 ELISA Kits)-HOXA9 (show HOXA9 ELISA Kits) to the HOXA locus and for NUP98 (show NUP98 ELISA Kits)-HOXA9 (show HOXA9 ELISA Kits)-induced HOXA gene expression. MLL (show MLL ELISA Kits) is crucial for NUP98 (show NUP98 ELISA Kits)-HOXA9 (show HOXA9 ELISA Kits) leukemia initiation.
Atg5 (show ATG5 ELISA Kits)-dependent autophagy contributes to the development of acute myeloid leukemia (show BCL11A ELISA Kits) in an MLL (show MLL ELISA Kits)-AF9 (show MLLT3 ELISA Kits)-driven mouse model.
These results reveal a cooperative transcriptional activation mechanism of AEP (show LGMN ELISA Kits) and DOT1L (show DOT1L ELISA Kits) and suggest a molecular rationale for the simultaneous inhibition of the MLL (show MLL ELISA Kits) fusion-AF4 complex and DOT1L (show DOT1L ELISA Kits) for more effective treatment of MLL (show MLL ELISA Kits)-rearranged leukemia.
This study demonstrated that Kmt2a (show MLL ELISA Kits) regulates synaptic plasticity in striatal neurons and provides an epigenetic drug target for anxiety and dopamine-mediated behaviors.
Inactivation of Kmt2a in Men1-deficient mice accelerated pancreatic islet tumorigenesis and shortened the average life span. Increases in cell proliferation were observed in mouse pancreatic islet tumors upon inactivation of both Kmt2a and Men1.
Data suggest that RAS-homolog enriched in brain protein (Rheb1) promotes MLL-AF9 fusion protein initiated acute myeloid leukemia (AML) progression through target of rapamycin complex 1 (mTORC1) signaling pathway.
HoxBlinc RNA Recruits Set1 (show SETD1A ELISA Kits)/MLL (show MLL ELISA Kits) Complexes to Activate Hox (show MSH2 ELISA Kits) Gene Expression Patterns and Mesoderm Lineage Development.
MLL1 and DOT1L (show DOT1L ELISA Kits) cooperate with meningioma-1 to induce acute myeloid leukemia (show BCL11A ELISA Kits).
Set1 role in cellular reprogramming and its interactions with Dpy30,Myc,Sox2 and Ash2l reprogramming factors
Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis (By similarity).
Mixed-lineage leukemia (also acute lymphocytic leukemia 1 or tritorax Drosophila gene)
, histone-lysine N-methyltransferase MLL
, myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)
, myeloid/lymphoid or mixed-lineage leukemia 1
, histone-lysine N-methyltransferase 2A
, lysine N-methyltransferase 2A
, myeloid/lymphoid or mixed-lineage leukemia protein 1
, trithorax Drosophila
, zinc finger protein HRX