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MYOCD encodes a nuclear protein, which is expressed in heart, aorta, and in smooth muscle cell-containing tissues. Additionally we are shipping Myocardin Antibodies (35) and and many more products for this protein.
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myocardin is an essential component of the regulatory pathway for myocardial differentiation
several transcription factors, that is SRF, myocardin, and GATA6, that induce the expression of SM-MHC in animal cap cells
our study reveals that Ang II (show AGT ELISA Kits) downregulates miR (show MLXIP ELISA Kits)-145 to regulate Klf4 (show KLF4 ELISA Kits) and myocardin expression in HCASMCs under high glucose conditions. Ang II (show AGT ELISA Kits) plays a critical role in the regulation of miR (show MLXIP ELISA Kits)-145 under hyperglycemic conditions
Human expression data disclosed correlations of MYOCD with CAV1 in a majority of human tissues and in the heart, correlation with MKL2 (MRTF-B) was observed.
inhibition of GSK-3beta reduces myocardin transcriptional activity, suggesting a role for GSK-3beta in myocardin transcriptional activity and smooth muscle differentiation
STAT3 protein regulates vascular smooth muscle cell phenotypic switch by interaction with myocardin and SRF.
TMEM16A (show ANO1 ELISA Kits) and myocardin form a positive feedback loop that is disrupted by KLF5 (show KLF5 ELISA Kits) during Ang II (show AGT ELISA Kits)-induced vascular remodeling.
TNFalpha (show TNF ELISA Kits) differentially regulates myocardin expression and activity
Propose myocardin as a guardian of the contractile, noninflammatory VSMC phenotype, with loss of myocardin representing a critical permissive step in the process of phenotypic transition and inflammatory activation, at the onset of vascular disease.
it is probably that miR135b promotes proliferation, invasion and migration of osteosarcoma cells by degrading myocardin
Early cardiac marker gene myocardin levels in peripheral blood mononuclear cells reflect severity in stable coronary artery disease.
Myocardin meditates apoptosis in breast cancer through affecting maspin (show SERPINB5 ELISA Kits) re-expression and epigenetic modification.
Knock down of the serum response factor (SRF), which mediates many of the effects of myocardin, decreased cavin-1 but increased caveolin-1 and -2 mRNAs.
Cholesterol loading of vascular smooth muscle cells converts them to a macrophage-appearing state by downregulating the miR (show MLXIP ELISA Kits)-143/145-myocardin axis.
Our data illustrate a novel mechanism that connects MRTF-A (show MKL1 ELISA Kits) dependent histone H3K4 methylation to HSC (show FUT1 ELISA Kits) activation.
DKK3 induces stem cell differentiation into smooth muscle lineage via ATF6 (show ATF6 ELISA Kits) signaling and myocardin expression.
Myocardin has a critical role in maintenance of vascular and visceral smooth muscle homeostasis during postnatal development
Foxf2 (show FOXF2 ELISA Kits) attenuated myocardin/serum response factor signaling in smooth muscle cells through direct binding to the N-terminal region of myocardin
The authors describe the of a Cre knock-in into the Myocardin locus and show that Myocardin expression marks the earliest cardiac and smooth muscle lineages.
KLF4 (show KLF4 ELISA Kits) is a regulator of cardiac hypertrophy by modulating the expression and the activity of myocardin.
a moderate inhibition (e.g., normalization) of the activated MYOCD signaling in the diseased heart may be promising from a therapeutic point of view
MYOCD DeltaExon 11 may participate in modulating smooth muscle cell phenotype, potentially acting as a dominant-negative repressor of contraction-related genes.
Data show that forced myocd-A expression in the LVFW caused abnormal ECG.
Thrombin (show F2 ELISA Kits) stimulates swine smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1 (show F2R ELISA Kits), RhoA (show RHOA ELISA Kits), and myocardin.
This gene encodes a nuclear protein, which is expressed in heart, aorta, and in smooth muscle cell-containing tissues. It functions as a transcriptional co-activator of serum response factor (SRF) and modulates expression of cardiac and smooth muscle-specific SRF-target genes, and thus may play a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, SRF co-factor protein (cardiac and smooth muscle)
, SRF cofactor protein
, basic SAP coiled-coil transcription activator 2
, transcription factor myocardin