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Myosin, Light Chain 2, Regulatory, Cardiac, Slow Proteins (MYL2)

Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Additionally we are shipping MYL2 Antibodies (93) and MYL2 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MYL2 17907 P97457
MYL2 4633 P10916
MYL2 363925 P08733
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Top MYL2 Proteins at antibodies-online.com

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human His tag Myosin, Light Chain 2, Regulatory, Cardiac, Slow (MYL2) (AA 8-164), (partial) protein (His tag) 50 μg Log in to see 9 to 11 Days
$242.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Yeast His tag   1 mg Log in to see 56 to 66 Days
$2,370.50
Details
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
$2,374.17
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,377.83
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,377.83
Details
HOST_Escherichia coli (E. coli) Human His tag   1 mg Log in to see 3 to 4 Days
$3,349.50
Details

MYL2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,
Rat (Rattus)

Top referenced MYL2 Proteins

  1. Human MYL2 Protein expressed in Escherichia coli (E. coli) - ABIN667089 : Macera, Szabo, Wadgaonkar, Siddiqui, Verma: Localization of the gene coding for ventricular myosin regulatory light chain (MYL2) to human chromosome 12q23-q24.3. in Genomics 1992 (PubMed)
    Show all 2 references for ABIN667089

More Proteins for Myosin, Light Chain 2, Regulatory, Cardiac, Slow (MYL2) Interaction Partners

Mouse (Murine) Myosin, Light Chain 2, Regulatory, Cardiac, Slow (MYL2) interaction partners

  1. Treatment of mice with an AT1R (show AGTRAP Proteins) biased ligand, acting via beta-arrestin signalling, is able to induce an increase in cardiac contractility associated with an increase in ventricular myosin light chain-2 (show MYL12B Proteins) phosphorylation

  2. Hypertrophic cardiomyopathy associated Lys104Glu mutation in the myosin regulatory light chain causes diastolic disturbance in mice.

  3. Mammalian target of rapamycin (mTOR (show FRAP1 Proteins)) inhibition with rapamycin improves cardiac function in type 2 diabetic mice: potential role of attenuated oxidative stress and altered contractile protein (show TNNT2 Proteins) expression.

  4. Data indicate that NRG-1beta up-regulated the gene expressions of Nkx2.5, GATA4, alpha-actin, MLC-2v, and ANF in a time-dependent regulation of ErbB/ERK1/2 pathways.

  5. Results indicated that sine oculis homeobox (show PRRX1 Proteins) 1 (Six1 (show SIX1 Proteins)) overexpression could significantly promote the expression of fast-type muscle genes Atp2a1 (show ATP2A1 Proteins), Srl (show SRL Proteins), and Mylpf (show MYLPF Proteins).

  6. High resolution characterization of myosin IIC protein tailpiece and its effect on filament assembly

  7. Accelerated cMLCK protein turnover by the ubiquitin-proteasome system underlies the transition from compensated hypertrophy to decompensated heart failure as a result of reduced phosphorylation of MLC2v.

  8. Results show that the binding force between selenium and cardiac myosin (CM), which consists of two heavy chains (MHC) and two pairs of light chains: MLC1 and MLC2, was 100 times stronger than that of daunorubicin (DNR) and CM.

  9. MLC2 isoforms play a role in tumorigenesis.

  10. Mlc2 phosphorylation regulates actin-myosin interactions in striated (show NSDHL Proteins) muscle contraction. It is important for feedback control of calcium-dependent thin-filament activation. Dephosphorylation can play a critical role in heart failure.

Human Myosin, Light Chain 2, Regulatory, Cardiac, Slow (MYL2) interaction partners

  1. FLNb (show FLNB Proteins) enhances invasion of cancer cells through phosphorylation of MRLC and FAK (show PTK2 Proteins).

  2. Ostf1b could constitutively activate the Rho kinase (show ROCK1 Proteins) 1 (ROCK1 (show ROCK1 Proteins)) and myosin light chain 2 (MLC2 (show MYL12B Proteins)) signalling pathway that promotes cell migration, epithelial mesenchymal transition (EMT (show ITK Proteins)) and cytoskeletal dynamics through stress fibre formation.

  3. Myosin regulatory light chain phosphorylation enhances cardiac beta-myosin in vitro motility under load.

  4. This review focuses on the regulatory functions of MLC-2 (show MYL9 Proteins) in the embryonic and adult heart, with an emphasis on phosphorylation-driven actions of MLC-2v in adult cardiac muscle.

  5. Data suggest a mutation in MYL2 (amino acid substitution D94A; novel mutation in familial dilated cardiomyopathy) does affect conformation (reduced alpha-helical content) and function (reduced binding of myosin heavy chain; increased ATPase) of MYL2.

  6. Four novel body mass index-associated loci near the KCNQ1 (show KCNQ1 Proteins)(rs2237892), ALDH2 (show ALDH2 Proteins)/MYL2 (rs671, rs12229654), ITIH4 (show ITIH4 Proteins) (rs2535633) and NT5C2 (show NT5C2 Proteins) (rs11191580) genes are identified in East Asian-ancestry populations.

  7. Results suggest that Aurora B (show AURKB Proteins), but not Rho/MLCK (myosin-light-chain kinase (show MYLK Proteins)) signaling, is essential for the localization of 2P-MRLC (myosin regulatory light chains) to the midzone in dividing HeLa cells.

  8. an interplay between phosphorylation and glycosylation of MLC2 (show MYL9 Proteins), which might be involved in the development of muscle atrophy and associated changes

  9. Newly implicated variants (MYL2, C12orf51 and OAS1 (show OAS1 Proteins)) were found to be significantly associated with 1-h plasma glucose as predisposing risk factors for type 2 diabetes.

  10. study concludes the mutations in the last exon of MYL2 are responsible for a novel autosomal recessive lethal myosinopathy due to defects changing the C-terminal tail of the ventricular form of the myosin regulatory light chain

MYL2 Protein Profile

Protein Summary

Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy.

Gene names and symbols associated with MYL2

  • myosin light chain, phosphorylatable, fast skeletal muscle (Mylpf)
  • Myosin regulatory light chain 2, ventricular/cardiac muscle isoform-like (LOC100353304)
  • myosin, light chain 2, regulatory, cardiac, slow (MYL2)
  • myosin, light chain 2, regulatory, cardiac, slow (Myl2)
  • myosin, light chain 9, regulatory (MYL9)
  • myosin, light polypeptide 2, regulatory, cardiac, slow (Myl2)
  • 2410014J02Rik protein
  • CMH10 protein
  • Mlc-2 protein
  • MLC-2v protein
  • MLC2 protein
  • Mlc2v protein
  • Mylpc protein
  • myosin protein
  • regulatory protein

Protein level used designations for MYL2

MLC2F , fast skeletal myosin light chain 2 , myosin light chain 2 , myosin regulatory light chain 2, skeletal muscle isoform , MLC-2 , MLC-2v , RLC of myosin , cardiac ventricular myosin light chain 2 , myosin regulatory light chain 2, ventricular/cardiac muscle isoform , myosin, light polypeptide 2, regulatory, cardiac, slow , regulatory light chain of myosin , slow cardiac myosin regulatory light chain 2 , cardiac myosin light chain-2 , DTNB , G1 , isoform L20-A , light polypeptide 9 , myosin regulatory light chain 2, smooth muscle major isoform , myosin regulatory light polypeptide 9 , myosin, light polypeptide 9, regulatory , smooth muscle major isoform , myosin light chain 2v , myosin light chain, phosphorylatable, cardiac ventricles , ventricular myosin regulatory light chain

GENE ID SPECIES
17907 Mus musculus
100353304 Oryctolagus cuniculus
4633 Homo sapiens
363925 Rattus norvegicus
505519 Bos taurus
396215 Gallus gallus
17906 Mus musculus
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