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anti-Myosin Binding Protein C, Cardiac (MYBPC3) Antibodies

MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Additionally we are shipping MYBPC3 Kits (16) and MYBPC3 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MYBPC3 17868  
MYBPC3 295929 P56741
MYBPC3 4607 Q14896
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Top anti-MYBPC3 Antibodies at antibodies-online.com

Showing 10 out of 62 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry analysis in human heart tissue (Formalin-fixed, Paraffin-embedded) using MYBPC3 Antibody (N-term), followed by peroxidase conjugated secondary antibody and DAB staining. This data demonstrates the use of this antibody for IHC. Clinical relevance has not been evaluated. Western blot analysis in mouse heart tissue lysates (35ug/lane) using MYBPC3 Antibody (N-term). This demonstrates this antibody detected the MYBPC3 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Mouse Rabbit Un-conjugated IHC (p), WB MYBPC3 Antibody (N-term) (ABIN656369) immunohistochemistry analysis in formalin fixed and paraffin embedded human heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human heart tissue, using MYBPC3 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC (p), ELISA 100 μL Log in to see 7 to 9 Days
$478.50
Details
Human Rabbit Un-conjugated ELISA, IHC   100 μL Log in to see 14 Days
$175.80
Details
Human Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of MYBPC3 staining in human heart formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the Western blot analysis of MYBPC3 expression in mouse heart (A), rat heart (B) whole cell lysates. 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Western Blot: MyBPC3 Antibody [NBP2-13632] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17,10. Lane 2: RT-4. Lane 3: U-251 MG. Lane 4:Human Plasma. Lane 5: Liver . Lane 6: Tonsil Immunohistochemistry-Paraffin: MyBPC3 Antibody [NBP2-13632] - MYBPC3 Antibody [NBP2-13632] - Staining of human heart muscle shows strong cytoplasmic positivity in myocytes. 0.1 mL Log in to see 10 to 13 Days
$439.69
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p) Immunohistochemistry-Paraffin: MyBPC3 Antibody [NBP2-13631] - MYBPC3 Antibody [NBP2-13631] - Staining of human heart muscle shows moderate cytoplasmic positivity in myocytes. Immunocytochemistry/Immunofluorescence: MyBPC3 Antibody [NBP2-13631] - MYBPC3 Antibody [NBP2-13631] - Staining of human cell line U-251 MG shows positivity in mitochondria. 0.1 mL Log in to see 10 to 13 Days
$439.69
Details
Rat Rabbit FITC ELISA, WB   100 μg Log in to see 7 to 9 Days
$581.17
Details

MYBPC3 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-MYBPC3 Antibodies

  1. Human Polyclonal MYBPC3 Primary Antibody for EIA, IHC (p) - ABIN953556 : Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. in Diabetes Care 2010 (PubMed)
    Show all 5 references for ABIN953556

More Antibodies against MYBPC3 Interaction Partners

Cow (Bovine) Myosin Binding Protein C, Cardiac (MYBPC3) interaction partners

  1. N terminus of cMyBP-C interacts with F-actin through multiple distinct binding sites and that binding at one or more sites is reduced by phosphorylation

Mouse (Murine) Myosin Binding Protein C, Cardiac (MYBPC3) interaction partners

  1. these data indicate a robust proinflammatory response in DCM hearts, likely in response to cellular damage triggered by MYBPC3 mutation and resultant contractile dysfunction.

  2. We provide evidence that haploinsufficiency and poison polypeptide hypotheses are disease mechanisms and that EHTs can be used as a platform to evaluate the direct impact of (newly identified) MYBPC3 gene variants.

  3. These results support the proposal that cMyBP-C stabilises the thick filament and that the loss of cMyBP-C results in an untethering of myosin heads.

  4. Crypts are a normal part of cardiac development but, along with the mitral valve and trabeculae, their developmental trajectory is altered by the presence of HCM truncating Mybpc3 gene mutation

  5. that in the homozygous hypertrophic cardiomyopathy mouse model, beta-AR stimulation leads to preferential PKA phosphorylation of phospholamban over cardiac troponin I, resulting in an impaired inotropic and lusitropic response

  6. Phosphorylation of MYBPC3 contributes to the genesis of ventricular wall geometry, linking myofilament biology with multiscale cardiac mechanics and myoarchitecture.

  7. The cMyBP-C hypertrophic cardiomyopathy variant L348P enhances thin filament activation through an increased shift in tropomyosin (show TPM2 Antibodies) position.

  8. The contributions of cardiac myosin binding protein C and troponin I phosphorylation to beta-adrenergic enhancement of in vivo cardiac function

  9. MYBPC3 mutations is elevated oxidative stress that corresponded to severe cardiac dysfunction, myocyte damage, and myocardial remodeling.

  10. MBPC and troponin-I phosphorylation modulate myofilament length-dependent activation

Human Myosin Binding Protein C, Cardiac (MYBPC3) interaction partners

  1. The authors demonstrate myosin tail (S2)-dependent functional regulation of actin-activated human beta-cardiac myosin ATPase (show DNAH8 Antibodies). In addition, they show that both S2 and MyBP-C bind to S1 and that phosphorylation of either S1 or MyBP-C weakens these interactions.

  2. Our study supports that mutations in MYH7 (show MYH7 Antibodies) and MYBPC3 should be the first focus of moleculargenetic analysis in HCM, and that mutations in TNNT2 (show TNNT2 Antibodies) have a low prevalence in Brazilian population. All mutations detected were missense mutations, whereas two mutations in MYH7 (show MYH7 Antibodies) had not been described before.

  3. These findings point to the critical role of MYBPC3 during sarcomere assembly in cardiac myocyte differentiation and suggest developmental influences of MYBPC3 truncating mutations on the mature hypertrophic phenotype.

  4. Study shows lack of phenotypic differences between MYH7 (show MYH7 Antibodies)- and MYBPC3-associated hypertrophic cardiomyopathy when assessed by cardiac magnetic resonance imaging.

  5. MYBPC3 and MYH7 (show MYH7 Antibodies) were the most common mutated genes, accounting for 27% of the total Hypertrophic Cardiomyopathy patients and 83% of the putative mutations in the main sarcomeric genes.

  6. MYBPC3 gene mutation is associated with Early-Onset Hypertrophic Cardiomyopathy.

  7. The results showed that MYBPC3 25-bp deletion polymorphism was significantly associated with elevated risk of left ventricular dysfunction (LVD), while TTN 18 bp I/D, TNNT2 5 bp I/D and myospryn K2906N polymorphisms did not show any significant association with LVD.

  8. we report a patient presenting with a complex phenotype consisting of severe, adult-onset, dilated cardiomyopathy, hearing loss and developmental delay, in which exome sequencing revealed two genetic variants that are inherited from a healthy mother: a variant, in MYBPC3, that is associated with hereditary cardiomyopathy.

  9. 5 out of 102 (4.9%) athletes carried mutations: a heterozygous MYH7 (show MYH7 Antibodies) Glu935Lys mutation, a heterozygous MYBPC3 Arg160Trp mutation and another heterozygous MYBPC3 Thr1046Met mutation, all of which had been reported as HCM-associated mutations

  10. a significant role of MYBPC3 gene mutations in Hypertrophic cardiomyopathy(HCM) disease and can be used for pre-symptomatic diagnosis of at risk family members of affected individuals.

Rabbit Myosin Binding Protein C, Cardiac (MYBPC3) interaction partners

  1. small es, CyrillicMyBP-C modulates interaction of myosin with actin

MYBPC3 Antigen Profile

Protein Summary

MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy.

Gene names and symbols associated with MYBPC3

  • myosin binding protein C, cardiac (mybpc3) antibody
  • myosin binding protein C, cardiac (MYBPC3) antibody
  • myosin binding protein C, cardiac (LOC100220915) antibody
  • myosin binding protein C, cardiac (Mybpc3) antibody
  • myosin binding protein C, cardiac (LOC100346773) antibody
  • CMH4 antibody
  • FHC antibody
  • hm:zehn0716 antibody
  • im:6900815 antibody
  • MGC114614 antibody
  • MYBP-C antibody
  • zgc:152717 antibody
  • zgc:158442 antibody

Protein level used designations for MYBPC3

myosin binding protein C, cardiac , cardiac myosin-binding protein C , protein C, cardiac , myosin-binding protein C, cardiac-type , cardiac myosin binding protein C , myosin-binding protein C, cardiac-type-like , C-protein, cardiac muscle isoform , cardiac C-protein , cardiac MyBP-C

GENE ID SPECIES
398261 Xenopus laevis
451168 Pan troglodytes
483624 Canis lupus familiaris
556489 Danio rerio
767614 Bos taurus
100105196 Felis catus
100127177 Xenopus (Silurana) tropicalis
100220915 Taeniopygia guttata
100452875 Pongo abelii
17868 Mus musculus
295929 Rattus norvegicus
4607 Homo sapiens
396013 Gallus gallus
100512088 Sus scrofa
100346773 Oryctolagus cuniculus
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