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Myosin Heavy Chain 11, Smooth Muscle Proteins (MYH11)

The protein encoded by MYH11 is a smooth muscle myosin belonging to the myosin heavy chain family. Additionally we are shipping MYH11 Antibodies (37) and MYH11 Kits (19) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Human MYH11 MYH11 4629 P35749
MYH11 24582  
Mouse MYH11 MYH11 17880  
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Top MYH11 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 11 to 13 Days
$792.00
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$2,066.17
Details
HOST_Escherichia coli (E. coli) Rat Un-conjugated   100 μg Log in to see 9 to 19 Days
$967.75
Details

MYH11 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

More Proteins for Myosin Heavy Chain 11, Smooth Muscle (MYH11) Interaction Partners

Human Myosin Heavy Chain 11, Smooth Muscle (MYH11) interaction partners

  1. Deletion mutation in MYH11 gene causing familial Thoracic aortic dissection was identified in two independent Japanese pedigrees.

  2. Data suggest that expression of MYH11, myosin light chain, and MLCK (myosin-light-chain kinase (show MYLK Proteins)), is up-regulated in uterine myoma as compared to adjacent smooth muscle cells; expression of MYH11 appears to be involved in cell proliferation.

  3. In familial AAA (show APP Proteins) we found one pathogenic and segregating variant (COL3A1 (show COL3A1 Proteins) p.Arg491X), one likely pathogenic and segregating (MYH11 p.Arg254Cys), and fifteen VUS.

  4. CBFB (show CBFB Proteins) contributes to the transcriptional regulation of ribosomal gene expression and provide further understanding of the epigenetic role of CBFB (show CBFB Proteins)-SMMHC in proliferation and maintenance of the leukemic phenotype.

  5. we report a novel hypomethylation pattern, specific to CBFB-MYH11 fusion resulting from inv(16) rearrangement in acute myeloid leukemia the expression of which correlated with PBX3 differential methylation

  6. overexpression of MYH11 can lead to increased ER stress and autophagy

  7. MYH11 gene mutation is associated with family history of thoracic aortic aneurysm dissection.

  8. Transcriptional analysis revealed that upon fusion protein knockdown, a small subset of the CBFbeta (show CBFB Proteins)-MYH11 target genes show increased expression, confirming a role in transcriptional repression

  9. MYH11 mutations are rare and are identified in patients with thoracic aortic aneurysm/dissection.

  10. Incomplete segregation of MYH11 variants with thoracic aortic aneurysms and dissections and patent ductus arteriosus.

Mouse (Murine) Myosin Heavy Chain 11, Smooth Muscle (MYH11) interaction partners

  1. Cbfbeta (show CBFB Proteins)-SMMHC and Nras (show NRAS Proteins)(G12D) promote the survival of preleukemic myeloid progenitors primed for leukemia by activation of the MEK (show MDK Proteins)/ERK (show EPHB2 Proteins)/Bim (show BCL2L11 Proteins) axis, and define Nras (show NRAS Proteins)(LSL-G12D); Cbfb (show CBFB Proteins)(56M) mice as a valuable genetic model for the study of AML (show RUNX1 Proteins) therapies.

  2. A rare variant in MYH11, R247C, alters myosin contractile function and smooth muscle cell phenotype, leading to increased proliferation in vitro and in response to vascular injury.

  3. Data show the cooperation between mutated KIT and CBFB (show CBFB Proteins)-MYH11 during leukemogenesis

  4. Cbfb (show CBFB Proteins)/Runx1 (show RUNX1 Proteins) repression-independent activities contribute to leukemogenesis by Cbfb (show CBFB Proteins)-MYH11

  5. Myh11 complexes with Cbfb (show CBFB Proteins) and inhibits the cell cycle.

  6. report the identification of genes that specifically cooperate with CBFB (show CBFB Proteins)-MYH11 in leukemogenesis

  7. Force dilatation pressure was decreased in smooth muscle B mysoin null mesenteric vessels. (Myosin B))

  8. provides a mechanistic basis for the myeloid-lineage bias of CBFbeta (show CBFB Proteins)-SMMHC-associated leukemia

  9. Runx2 (show RUNX2 Proteins) is expressed in the stem cell compartment, interferes with differentiation and represses CBF targets in the myeloid compartment, and modulates the leukemogenic function of Cbfbeta (show CBFB Proteins)-SMMHC in mouse leukemia.

MYH11 Protein Profile

Protein Summary

The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16

Gene names and symbols associated with MYH11

  • myosin, heavy chain 11, smooth muscle (MYH11)
  • myosin, heavy chain 11, smooth muscle (Myh11)
  • myosin, heavy polypeptide 11, smooth muscle (Myh11)
  • AAT4 protein
  • AV071570 protein
  • FAA4 protein
  • myosin protein
  • SM1 protein
  • SM2 protein
  • SMHC protein
  • smMHC protein

Protein level used designations for MYH11

myosin heavy chain 11 , myosin heavy chain, smooth muscle isoform , myosin, heavy polypeptide 11, smooth muscle , myosin-11 , myosin heavy chain SMA , SMMHC , myosin heavy chain 21 , smooth muscle myosin heavy chain , MHC , gizzard smooth muscle , heavy polypeptide 11 , myosin heavy chain, gizzard smooth muscle , smooth muscle , myosin heavy chain 11, smooth muscle

GENE ID SPECIES
4629 Homo sapiens
530050 Bos taurus
24582 Rattus norvegicus
396211 Gallus gallus
100009145 Oryctolagus cuniculus
17880 Mus musculus
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