anti-Myosin Heavy Chain 7, Cardiac Muscle, beta (MYH7) Antibodies

Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. Additionally we are shipping Myosin Heavy Chain 7, Cardiac Muscle, beta Kits (26) and Myosin Heavy Chain 7, Cardiac Muscle, beta Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MYH7 4625 P12883
MYH7 29557 P02564
MYH7 140781 Q91Z83
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Top anti-Myosin Heavy Chain 7, Cardiac Muscle, beta Antibodies at antibodies-online.com

Showing 10 out of 56 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB <b>WB Suggested Anti-Myh7 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:62500<br><b>Positive Control: </b>Mouse Spleen 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated IHC (p), WB   0.1 mg Log in to see 6 to 8 Days
$313.50
Details
Human Mouse Un-conjugated IHC (p), WB Anti-Myosin(Skeletal, Slow) antibody (monoclonal), Western blotting WB: Rat Skeletal Muscle Tissue Lysate 100 μg Log in to see 4 to 6 Days
$200.00
Details
Human Rabbit Un-conjugated IF (p), IHC (p) Antigen: 2 µg/100 µL  Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000;  Secondary: HRP conjugated Rabbit Anti-Goat IgG at 1: 5000;  TMB staining Read the data in Microplate Reader by 450nm. 100 μL Log in to see 3 to 7 Days
$295.90
Details
Human Rabbit Un-conjugated WB MYH7 Antibody (N-term)  western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the MYH7 antibody detected the MYH7 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Bat Rabbit Un-conjugated IHC (p), WB Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 7 to 9 Days
$676.50
Details
Human Rabbit Alexa Fluor 594 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details
Human Rabbit Cy3 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details
Human Rabbit Cy5 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details
Human Rabbit Cy5.5 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details

MYH7 Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-Myosin Heavy Chain 7, Cardiac Muscle, beta Antibodies

  1. Cow (Bovine) Polyclonal MYH7 Primary Antibody for IHC, WB - ABIN2776777 : Tijore, Hariharan, Yu, Lam, Wen, Tay, Ahmed, Tan: Investigating the spatial distribution of integrin β₁ in patterned human mesenchymal stem cells using super-resolution imaging. in ACS applied materials & interfaces 2014 (PubMed)
    Show all 2 Pubmed References

More Antibodies against Myosin Heavy Chain 7, Cardiac Muscle, beta Interaction Partners

Human Myosin Heavy Chain 7, Cardiac Muscle, beta (MYH7) interaction partners

  1. We investigated a male with familial familial hypertrophic cardiomyopathy with restrictive physiology and we identified a novel missense mutation p.Arg719Leu of beta-myosin heavy chain (MYH7) gene

  2. ur results suggest that the basis for the pathogenic effect of the R1845W and H1901L mutations of the MYH7 are primarily structural rather than functional. Further analyses are needed to identify the primary trigger for the histological changes seen in muscle biopsies of patients with L1793P and E1883K mutations.

  3. The authors demonstrate myosin tail (S2)-dependent functional regulation of actin-activated human beta-cardiac myosin ATPase (show DNAH8 Antibodies). In addition, they show that both S2 and MyBP-C (show MYBPC3 Antibodies) bind to S1 and that phosphorylation of either S1 or MyBP-C (show MYBPC3 Antibodies) weakens these interactions.

  4. Our study supports that mutations in MYH7 and MYBPC3 (show MYBPC3 Antibodies) should be the first focus of moleculargenetic analysis in HCM, and that mutations in TNNT2 (show TNNT2 Antibodies) have a low prevalence in Brazilian population. All mutations detected were missense mutations, whereas two mutations in MYH7 had not been described before.

  5. Study shows lack of phenotypic differences between MYH7- and MYBPC3 (show MYBPC3 Antibodies)-associated hypertrophic cardiomyopathy when assessed by cardiac magnetic resonance imaging.

  6. Two novel heterozygous proline substitutions located in exon 31 of MYH7 within its rod domain:c.4309G>C (p.Ala1437Pro) and c.4301G>C (p.Arg1434Pro) is causing skeletal myopathies.

  7. MYBPC3 (show MYBPC3 Antibodies) and MYH7 were the most common mutated genes, accounting for 27% of the total Hypertrophic Cardiomyopathy patients and 83% of the putative mutations in the main sarcomeric genes.

  8. MYH7 gene mutation is associated with Early-Onset Hypertrophic Cardiomyopathy.

  9. family members who carried both the MYH7-A719H and MYOZ2 (show MYOZ2 Antibodies)-L169G mutations had more severe symptoms of hypertrophic cardiomyopathy, including sudden cardiac death, than those with only the MYH7 mutation

  10. Chinese family with dual LQT1 (show KCNQ1 Antibodies) and HCM phenotypes associated with tetrad heterozygous mutations in KCNQ1 (show KCNQ1 Antibodies), MYH7, MYLK2 (show MYLK2 Antibodies), and TMEM70 (show TMM70 Antibodies) mutations.

Cow (Bovine) Myosin Heavy Chain 7, Cardiac Muscle, beta (MYH7) interaction partners

  1. Tm affects the conformation of actin so as to increase the area of hydrophobic interaction between actin and myosin molecules

Pig (Porcine) Myosin Heavy Chain 7, Cardiac Muscle, beta (MYH7) interaction partners

  1. Myosin regulatory light chain phosphorylation enhances cardiac beta-myosin in vitro motility under load.

  2. Mutation analysis of MYH7 gene revealed an in-frame insertion within exon 30 of MYH7 which was perfectly associated with the disease phenotype and confirmed the dominant inheritance.

Mouse (Murine) Myosin Heavy Chain 7, Cardiac Muscle, beta (MYH7) interaction partners

  1. Male/female Myh7 mutant mice display sex dimorphic crossbridge kinetics accompanied by sex- and hypertrophic cardiomyopathy-dependent cardiac remodeling at the morphometric, histological, and cellular level.

  2. The promoter regions of the SERCA (show ATP2A3 Antibodies)-2A and beta-MHC genes, Atp2a2 (show ATP2A2 Antibodies) and Myh7, respectively in murine hearts after one or eight weeks of pressure overload induced by transverse aortic constriction, were evaluated.

  3. Foxo1 (show FOXO1 Antibodies) has important roles in promoting diabetic cardiomyopathy and controls beta-MHC expression in the development of cardiac dysfunction.

  4. Cooperative/allosteric effects on actomyosin crossbridge recruitment dynamics are increased by beta-MHC.

  5. Reexpression of bMHC is associated at the bMHC promoter with increased H3ac but not H3K4me3.

  6. Metabolic and myosin isoform gene expression switch in sepsis-induced myocardial depression is inducible nitric oxide synthase (show NOS2 Antibodies)-dependent.

  7. residues situated within or close to the actin-binding interface of the myosin head influence actin binding and thereby modulate actin-activated ATPase (show DNAH8 Antibodies) activity

  8. Simultaneous defects in MHC7 & TnI (show TNNI2 Antibodies) accelerate onset & progression of familial hypertrophic cardiomyopathy. Compared with single-mutant models, double-mutant mice develop severe disease & premature death, progressing directly to a dilated phenotype.

  9. the functional consequences of the mutation are fundamentally changed depending upon the context of the cardiac MHC isoform.

Myosin Heavy Chain 7, Cardiac Muscle, beta (MYH7) Antigen Profile

Protein Summary

Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy.

Gene names and symbols associated with MYH7

  • myosin, heavy chain 7, cardiac muscle, beta (MYH7) antibody
  • myosin, heavy chain 16 (MYH16) antibody
  • myosin, heavy chain 7, cardiac muscle, beta (Myh7) antibody
  • myosin, heavy polypeptide 7, cardiac muscle, beta (Myh7) antibody
  • slow myosin heavy chain 1 (SM1) antibody
  • AMHC1 antibody
  • B-MHC antibody
  • beta-MHC antibody
  • CMD1S antibody
  • CMH1 antibody
  • MPD1 antibody
  • Myhc-b antibody
  • MyHC-I antibody
  • Myhcb antibody
  • myosin antibody
  • myosin-7 antibody
  • SPMD antibody
  • SPMM antibody

Protein level used designations for MYH7

cardiac muscle , chick atrial myosin heavy chain , heavy polypeptide 7 , myosin heavy chain , myosin, heavy polypeptide 7, cardiac muscle, beta , myosin-7 , masticatory myosin heavy chain 16 , beta-myosin heavy chain , myHC-beta , myhc-slow , myopathy, distal 1 , myosin heavy chain (AA 1-96) , myosin heavy chain 7 , myosin heavy chain slow isoform , myosin heavy chain, cardiac muscle beta isoform , rhabdomyosarcoma antigen MU-RMS-40.7A , beta myosin heavy chain , myHC-slow , myosin heavy chain polypeptide 7 cardiac muscle fetal , myosin heavy chain, cardiac muscle, fetal , myosin heavy chain, polypeptide 7 , type slow/beta myosin heavy chain , beta cardiac myosin heavy chain , myosin 7 , myosin heavy chain slow type 1 (beta cardiac) , MYH-beta/slow , cardiac myosin heavy chain beta

GENE ID SPECIES
395350 Gallus gallus
489862 Canis lupus familiaris
4625 Homo sapiens
29557 Rattus norvegicus
282714 Bos taurus
403807 Canis lupus familiaris
791234 Equus caballus
396860 Sus scrofa
100101566 Oryctolagus cuniculus
140781 Mus musculus
396063 Gallus gallus
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