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anti-Myosin Light Chain 2 (MYL2) Antibodies

MYL2 encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK).

list all antibodies Gene Name GeneID UniProt
Anti-Human MYL2 MYL2 4633 P10916
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More Antibodies against Myosin Light Chain 2 Interaction Partners

Human Myosin Light Chain 2 (MYL2) interaction partners

  1. Transient knockdown of PRKDC (show PRKDC Antibodies) reduced cell proliferation/survival in HCT116 and DLD1, but not FHC (show FTH1 Antibodies) cells. PRKDC (show PRKDC Antibodies) down-regulation induced apoptosis partially through inhibiting AKT (show AKT1 Antibodies) activation, and sensitized HCT116 cells to chemotherapeutic agents

  2. DNA methylation (show HELLS Antibodies) modification plays an important role to regulate the gene expression of XRCC5 (show XRCC5 Antibodies) and XRCC7 (show PRKDC Antibodies), from the results that the gene methylation level of the glioma group is higher than that of the normal group

  3. The ends are then closely aligned, which requires XLF (show NHEJ1 Antibodies), a non-catalytic function of XRCC4 (show XRCC4 Antibodies)-LIG4 (show LIG4 Antibodies), and DNA-PK activity

  4. suggested that DNA-PK and PARP (show COL11A2 Antibodies)-dependent recruitment of XRCC1 (show XRCC1 Antibodies) is necessary to effectively protect, repair, and restart stalled replication forks, providing new insight into how genomic stability is preserved

  5. Data show that inhibition of DNA-dependent protein kinase catalytic subunit (show PRKDC Antibodies) (DNA-PK) prevents type I DNA topoisomerase (Top1 (show TOP1 Antibodies)) degradation and proteasome activity in camptothecin (CPT (show CHPT1 Antibodies))-treated quiescent WI38 cells.

  6. These results provide new evidence linking cell cycle to bystander responses and demonstrate that DNA-PKcs (show PRKDC Antibodies) and ATM (show ATM Antibodies) are two associated factors in co-regulating G2-M phase-related bystander effects.

  7. CD133 and DNAPK (show PRKDC Antibodies) regulate MDR1 (show TBC1D9 Antibodies) via the PI3K (show PIK3CA Antibodies)- or Akt (show AKT1 Antibodies)-NF-kappaB (show NFKB1 Antibodies) pathway in multidrug-resistant glioblastoma cells.

  8. c-Myc (show MYC Antibodies) protein functions in the process of DNA double-strand break repair, at least partially, through affecting the ATM (show ATM Antibodies) phosphorylation and DNA-PKcs (show PRKDC Antibodies) kinase activity.

  9. DNA-PKcs (show PRKDC Antibodies) has a role in cancer metastasis through regulation of secreted proteins involved in migration and invasion

  10. Results show that activated DNA-PKcs (show PRKDC Antibodies) is elevated in medullary thyroid tumor samples and its expression correlates with expression of RET (show RET Antibodies) in thyroid tumors.

Fruit Fly (Drosophila melanogaster) Myosin Light Chain 2 (MYL2) interaction partners

  1. cycles of myosin-mediated contraction and relaxation, tightly linked to Cdc2 (show CDK1 Antibodies) and Rho kinase (show ROCK1 Antibodies) activity, are directly responsible for the axial expansion of the syncytial nuclei.

Xenopus laevis Myosin Light Chain 2 (MYL2) interaction partners

  1. Ku80 (show XRCC5 Antibodies) is susceptible to proteolytic degradation when not dimerized with Ku70 (show XRCC6 Antibodies); dimer induces DNA-PK activity; evidence that interacting domain(s) of Xenopus DNA-PKcs (show PRKDC Antibodies) is conserved so as to interact with human Ku, reconstituting a functional holoenzyme

Myosin Light Chain 2 (MYL2) Antigen Profile

Protein Summary

This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.

Gene names and symbols associated with MYL2

  • myosin, light chain 2, regulatory, cardiac, slow (MYL2) antibody
  • Myosin light chain 2 (Mlc2) antibody
  • protein kinase, DNA-activated, catalytic polypeptide (PRKDC) antibody
  • protein kinase, DNA-activated, catalytic polypeptide (prkdc) antibody
  • CG2184 antibody
  • CMH10 antibody
  • DmelCG2184 antibody
  • Dmlc2 antibody
  • DmMLC2 antibody
  • DNA-PKCS antibody
  • dnapk antibody
  • dnpk1 antibody
  • dro MLC-2 antibody
  • hyrc antibody
  • hyrc1 antibody
  • Ifm(3)99Eb antibody
  • l(3)99Eb antibody
  • LC2 antibody
  • MLC-2 antibody
  • MLC2 antibody
  • MRLC antibody
  • MYL2 antibody
  • p350 antibody
  • PRKDC antibody
  • prkdc-A antibody
  • RLC antibody
  • RLC2 antibody
  • xrcc7 antibody

Protein level used designations for MYL2

MLC-2 , MLC-2v , RLC of myosin , cardiac ventricular myosin light chain 2 , myosin light chain 2 , myosin regulatory light chain 2, ventricular/cardiac muscle isoform , myosin, light polypeptide 2, regulatory, cardiac, slow , regulatory light chain of myosin , slow cardiac myosin regulatory light chain 2 , myosin light chain 2, isoform A , CG2184-PA , Mlc2-PA , myosin LC2 , muscle-specific myosin regulatory light chain , myosin light Chain-2 , myosin regulatory light chain , myosin light chain 2, isoform B , CG2184-PB , Mlc2-PB , DNA-PK catalytic subunit , DNA-dependent protein kinase catalytic subunit , hyper-radiosensitivity of murine scid mutation, complementing 1 , p460 , protein kinase, DNA-activated, catalytic polypeptide , protein kinase catalytic subunit (DNA-dependent protein kinase) , DNA-PKcs , DNA-activated protein kinase catalytic polypeptide , DNA-dependent protein kinase catalytic subunit-like

GENE ID SPECIES
4633 Homo sapiens
43587 Drosophila melanogaster
5591 Homo sapiens
282003 Bos taurus
373602 Xenopus laevis
395376 Gallus gallus
418814 Gallus gallus
464165 Pan troglodytes
474176 Canis lupus familiaris
512740 Bos taurus
100125348 Oryctolagus cuniculus
100224961 Taeniopygia guttata
100399020 Callithrix jacchus
100586225 Nomascus leucogenys
100633457 Amphimedon queenslandica
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