anti-Myosin Light Chain 2 (MYL2) Antibodies

MYL2 encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK).

list all antibodies Gene Name GeneID UniProt
Anti-Human MYL2 MYL2 4633 P10916
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More Antibodies against Myosin Light Chain 2 Interaction Partners

Human Myosin Light Chain 2 (MYL2) interaction partners

  1. that EZH2 (show EZH2 Antibodies) is phosphorylated by the DNA damage responsive complex DNA-PK and regulates DNA damage-mediated T-cell apoptosis.

  2. differential regulation of PKA and cell stiffness in unconfined versus confined cells is abrogated by dual, but not individual, inhibition of Piezo1 and myosin II.

  3. DNA-PKcs (show PRKDC Antibodies) is a potent regulator of IL-2 (show IL2 Antibodies) production in T lymphocytes.

  4. Mutation in myosin regulatory light chain gene is associated with defective myosin motor function that ultimately result in pathological hypertrophic remodeling.

  5. Lipolysis-stimulated lipoprotein receptors (LSRs) localized to bicellular junctions in association with myosin regulatory light chain 2 (MRLC2 (show MYL12B Antibodies)) at low cell densities and to tricellular contacts when myosin phosphatase target subunit 1 (MYPT1 (show PPP1R12A Antibodies)) localized to the bicellular regions.

  6. Structural dynamics-based approach reveals that the E56G mutation in human ventricular essential light chain affects the structure of the actin-myosin complex in the presence of ATP. The mutation increases the population in the S structural state (increasing the duty ratio), and changes the structure of the W state, so that it more closely resembles the S state.

  7. TMU-35435 enhances etoposide cytotoxicity by regulating ubiquitin-proteasomal degradation of DNA-PKcs (show PRKDC Antibodies) and inhibiting the DNA repair pathway in triple negative breast cancer cells.

  8. DNA-PK directly phosphorylates hSSB1 (show SSBP1 Antibodies) at serine residue 134. While this modification is largely suppressed in undamaged cells by PPP-family protein phosphatases, S134 phosphorylation is enhanced following the disruption of replication forks and promotes cellular survival.

  9. DNA-PK activity in peripheral blood lymphocytes might be a useful marker for predicting prostate-specific antigen (show KLK3 PLURAL_@3975@) relapse and urinary toxicity, possibly contributing to personalized treatment of prostate cancer.

  10. Data suggest that the model can replicate amplified p53 (show TP53 Antibodies) responses under DNA-PK inhibition and provide insights into cell fate decision by manipulating p53 (show TP53 Antibodies) dynamics.

Fruit Fly (Drosophila melanogaster) Myosin Light Chain 2 (MYL2) interaction partners

  1. cycles of myosin-mediated contraction and relaxation, tightly linked to Cdc2 (show CDK1 Antibodies) and Rho kinase (show ROCK1 Antibodies) activity, are directly responsible for the axial expansion of the syncytial nuclei.

Xenopus laevis Myosin Light Chain 2 (MYL2) interaction partners

  1. Ku80 (show XRCC5 Antibodies) is susceptible to proteolytic degradation when not dimerized with Ku70 (show XRCC6 Antibodies); dimer induces DNA-PK activity; evidence that interacting domain(s) of Xenopus DNA-PKcs (show PRKDC Antibodies) is conserved so as to interact with human Ku, reconstituting a functional holoenzyme

Myosin Light Chain 2 (MYL2) Antigen Profile

Protein Summary

This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.

Gene names and symbols associated with MYL2

  • myosin, light chain 2, regulatory, cardiac, slow (MYL2) antibody
  • Myosin light chain 2 (Mlc2) antibody
  • protein kinase, DNA-activated, catalytic polypeptide (PRKDC) antibody
  • protein kinase, DNA-activated, catalytic polypeptide (prkdc) antibody
  • CG2184 antibody
  • CMH10 antibody
  • DmelCG2184 antibody
  • Dmlc2 antibody
  • DmMLC2 antibody
  • DNA-PKCS antibody
  • dnapk antibody
  • dnpk1 antibody
  • dro MLC-2 antibody
  • hyrc antibody
  • hyrc1 antibody
  • Ifm(3)99Eb antibody
  • l(3)99Eb antibody
  • LC2 antibody
  • MLC-2 antibody
  • MLC2 antibody
  • MRLC antibody
  • MYL2 antibody
  • p350 antibody
  • PRKDC antibody
  • prkdc-A antibody
  • RLC antibody
  • RLC2 antibody
  • xrcc7 antibody

Protein level used designations for MYL2

MLC-2 , MLC-2v , RLC of myosin , cardiac ventricular myosin light chain 2 , myosin light chain 2 , myosin regulatory light chain 2, ventricular/cardiac muscle isoform , myosin, light polypeptide 2, regulatory, cardiac, slow , regulatory light chain of myosin , slow cardiac myosin regulatory light chain 2 , myosin light chain 2, isoform A , CG2184-PA , Mlc2-PA , myosin LC2 , muscle-specific myosin regulatory light chain , myosin light Chain-2 , myosin regulatory light chain , myosin light chain 2, isoform B , CG2184-PB , Mlc2-PB , DNA-PK catalytic subunit , DNA-dependent protein kinase catalytic subunit , hyper-radiosensitivity of murine scid mutation, complementing 1 , p460 , protein kinase, DNA-activated, catalytic polypeptide , protein kinase catalytic subunit (DNA-dependent protein kinase) , DNA-PKcs , DNA-activated protein kinase catalytic polypeptide , DNA-dependent protein kinase catalytic subunit-like

GENE ID SPECIES
4633 Homo sapiens
43587 Drosophila melanogaster
5591 Homo sapiens
282003 Bos taurus
373602 Xenopus laevis
395376 Gallus gallus
418814 Gallus gallus
464165 Pan troglodytes
474176 Canis lupus familiaris
512740 Bos taurus
100125348 Oryctolagus cuniculus
100224961 Taeniopygia guttata
100399020 Callithrix jacchus
100586225 Nomascus leucogenys
100633457 Amphimedon queenslandica
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