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MYLK, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. Additionally we are shipping Myosin Light Chain Kinase Antibodies (94) and Myosin Light Chain Kinase Kits (27) and many more products for this protein.
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loss of MLCK contributes to the migratory properties of epithelial cells resulting from changes in cell-cell and cell-matrix adhesions, and increased epidermal growth factor receptor (show EGFR Proteins) signaling.
Sixty-seven experienced runners competed in a marathon race. The MLCK genotype (C37885A) of these marathoners was determined. CA heterozygotes for MLCK C37885A might present higher exercise-induced muscle damage after a marathon competition than CC counterparts.
these Acute respiratory distress syndrome (ARDS)-associated MYLK cytosine-guanine dinucleotides with effect modification by ethnicity and local modified cytosine quantitative trait loci suggest that MYLK epigenetic variation and local genetic background may contribute to health disparities observed in ARDS.
mechanical stress and MYLK single nucleotide polymorphism regulate MYLK alternative splicing.
Rebeccamycin attenuates TNF-alpha (show TNF Proteins)-induced disruption of intestinal epithelial barrier integrity by inducing claudin-5 (show CLDN5 Proteins) expression and suppressing MLCK production via Chk1 (show CHEK1 Proteins) activation.
Data show that alterations in myosin light chain kinase activity, claudin-15 (show CLDN15 Proteins) and claudin-2 (show CLDN2 Proteins) expression are associated with gluten-induced symptomatology and intestinal permeability changes in diarrhea-predominant irritable bowel syndrome (IBS-D).
PXR (show NR1I2 Proteins) regulates the intestinal epithelial barrier during inflammation by modulating cytokine-induced MLCK expression and JNK1 (show MAPK8 Proteins)/2 activation
A 2-bp deletion in myosin light chain kinase (c3272_3273del, p.Ser1091*) that led to a premature stop codon have a high risk of presenting with an acute aortic dissection or rupture.
In contrast to mylk2 (show MYLK2 Proteins) and mylk3 (show MYLK3 Proteins), mylk1 has a complex structure, and multiple protein products of the mylk1 gene are expressed in most if not all cell types. This review deals with the mylk1 gene and its protein products- multiple MLCK isoforms and noncatalytic KRP/telokin protein. [Review]
Likely pathogenic variants included a TGFB2 (show TGFB2 Proteins) variant in one patient and a SMAD3 (show SMAD3 Proteins) variant in another. These variants have been reported previously in individuals with similar phenotypes. Variants of uncertain significance of particular interest included novel variants in MYLK and MFAP5 (show MFAP5 Proteins), which were identified in a third patient
Histamine induces myosin light chain (MLC)phosphorylation via MYLK, suggesting regulatory role for MLC in controlling corneal epithelial permeability.
evaluated the spatial arrangement of the catalytic/regulatory domain, three immunoglobulin-related motifs, one fibronectin-related motif, a repetitive, proline-rich segment, and, at the N-terminus, a unique F-actin-binding domain.
telokin may play a role in attenuating constitutive myosin light chain phosphorylation
MLCK is linked to timely blastocyst formation, though it is dispensable for oocyte meiotic maturation
NF-kappaB (show NFKB1 Proteins) novel partner within endothelial cells
MLCK regulates cell migration in a myosin regulatory light chain phosphorylation-independent mechanism.
nmMlck modulates IL-1beta (show IL1B Proteins)-mediated downregulation of Cldn5 (show CLDN5 Proteins) in brain microvascular endothelial cells.
a prominent effect of the multifunctional microRNA-155 in endothelial cells is modulation of phenotype through alterations in RhoA, myosin light chain kinase expression, and actin cytoskeleton organization
CArG element in intron 15 of the mylk1 gene is necessary for maximal expression of the 130-kDa smMLCK and that the 130-kDa smMLCK isoform is specifically required to regulate smooth muscle contractility
In immune-mediated inflammatory bowel disease, tight junction dysregulation and barrier loss is induced by MLCK, but at advanced stages, barrier loss is MLCK-independent.
Claudin-2 (show CLDN2 Proteins) assumes an important role in colorectal inflammation, and furthermore implicates the involvement of MLCK in colon inflammation.
involved in IL-1beta (show IL1B Proteins)-induced increase in intestinal permeability
This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts.
kinase related protein, telokin
, myosin, light chain kinase
, myosin light chain kinase
, myosin light chain kinase, smooth muscle-like
, kinase-related protein
, myosin light chain kinase, smooth muscle
, myosin, light polypeptide kinase
, smooth muscle myosin light chain kinase
, smooth muscle myosin light chain kinase (61-kDa active fragment)