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Myosin Light Chain Kinase Proteins (MYLK)

MYLK, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. Additionally we are shipping Myosin Light Chain Kinase Antibodies (88) and Myosin Light Chain Kinase Kits (24) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MYLK 4638 Q15746
Rat MYLK MYLK 288057  
MYLK 107589  
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Top Myosin Light Chain Kinase Proteins at antibodies-online.com

Showing 10 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$774.40
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$792.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$2,297.17
Details
Yeast Sheep His tag   1 mg Log in to see 56 to 66 Days
$3,224.83
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details
Insect Cells Human GST tag   10 μg Log in to see 3 to 4 Days
$310.00
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 16 Days
$831.88
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 16 Days
$845.63
Details

MYLK Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,
Mouse (Murine)

More Proteins for Myosin Light Chain Kinase (MYLK) Interaction Partners

Human Myosin Light Chain Kinase (MYLK) interaction partners

  1. Rebeccamycin attenuates TNF-alpha (show TNF Proteins)-induced disruption of intestinal epithelial barrier integrity by inducing claudin-5 (show CLDN5 Proteins) expression and suppressing MLCK production via Chk1 (show CHEK1 Proteins) activation.

  2. Data show that alterations in myosin light chain kinase activity, claudin-15 (show CLDN15 Proteins) and claudin-2 (show CLDN2 Proteins) expression are associated with gluten-induced symptomatology and intestinal permeability changes in diarrhea-predominant irritable bowel syndrome (IBS-D).

  3. PXR (show NR1I2 Proteins) regulates the intestinal epithelial barrier during inflammation by modulating cytokine-induced MLCK expression and JNK1 (show MAPK8 Proteins)/2 activation

  4. A 2-bp deletion in myosin light chain kinase (c3272_3273del, p.Ser1091*) that led to a premature stop codon have a high risk of presenting with an acute aortic dissection or rupture.

  5. In contrast to mylk2 (show MYLK2 Proteins) and mylk3 (show MYLK3 Proteins), mylk1 has a complex structure, and multiple protein products of the mylk1 gene are expressed in most if not all cell types. This review deals with the mylk1 gene and its protein products- multiple MLCK isoforms and noncatalytic KRP/telokin protein. [Review]

  6. Likely pathogenic variants included a TGFB2 (show TGFB2 Proteins) variant in one patient and a SMAD3 (show SMAD3 Proteins) variant in another. These variants have been reported previously in individuals with similar phenotypes. Variants of uncertain significance of particular interest included novel variants in MYLK and MFAP5 (show MFAP5 Proteins), which were identified in a third patient

  7. suggest a novel role for myosin light chain and myosin light chain kinase in advanced glycation end product-induced endothelial hyperpermeability

  8. TKS5 and MYLK represent two mediators of invasive behavior of cancer cells that are regulated by the ZEB1/miR (show MLXIP Proteins)-200 feedback loop

  9. We speculate that the drop of the ROCK-to-MLCK ratio may occur as an attempt to compensate for the increased Rho kinase (show ROCK1 Proteins) activity.

  10. study demonstrates that G. duodenalis-mediated disruption of villin is, at least, in part dependent on activation of myosin light chain kinase (MLCK).

Cow (Bovine) Myosin Light Chain Kinase (MYLK) interaction partners

  1. Histamine induces myosin light chain (MLC)phosphorylation via MYLK, suggesting regulatory role for MLC in controlling corneal epithelial permeability.

Rabbit Myosin Light Chain Kinase (MYLK) interaction partners

  1. evaluated the spatial arrangement of the catalytic/regulatory domain, three immunoglobulin-related motifs, one fibronectin-related motif, a repetitive, proline-rich segment, and, at the N-terminus, a unique F-actin-binding domain.

Mouse (Murine) Myosin Light Chain Kinase (MYLK) interaction partners

  1. telokin may play a role in attenuating constitutive myosin light chain phosphorylation

  2. MLCK is linked to timely blastocyst formation, though it is dispensable for oocyte meiotic maturation

  3. NF-kappaB (show NFKB1 Proteins) novel partner within endothelial cells

  4. MLCK regulates cell migration in a myosin regulatory light chain phosphorylation-independent mechanism.

  5. nmMlck modulates IL-1beta (show IL1B Proteins)-mediated downregulation of Cldn5 (show CLDN5 Proteins) in brain microvascular endothelial cells.

  6. a prominent effect of the multifunctional microRNA-155 in endothelial cells is modulation of phenotype through alterations in RhoA, myosin light chain kinase expression, and actin cytoskeleton organization

  7. CArG element in intron 15 of the mylk1 gene is necessary for maximal expression of the 130-kDa smMLCK and that the 130-kDa smMLCK isoform is specifically required to regulate smooth muscle contractility

  8. In immune-mediated inflammatory bowel disease, tight junction dysregulation and barrier loss is induced by MLCK, but at advanced stages, barrier loss is MLCK-independent.

  9. Claudin-2 (show CLDN2 Proteins) assumes an important role in colorectal inflammation, and furthermore implicates the involvement of MLCK in colon inflammation.

  10. involved in IL-1beta (show IL1B Proteins)-induced increase in intestinal permeability

Myosin Light Chain Kinase (MYLK) Protein Profile

Protein Summary

This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts.

Gene names and symbols associated with MYLK

  • myosin light chain kinase (MYLK)
  • myosin light chain kinase (Mylk)
  • myosin, light polypeptide kinase (Mylk)
  • 9530072E15Rik protein
  • A930019C19Rik protein
  • AAT7 protein
  • AW489456 protein
  • KRP protein
  • Mlck protein
  • MLCK1 protein
  • MLCK108 protein
  • MLCK210 protein
  • MSTP083 protein
  • MYLK1 protein
  • SMMLCK protein

Protein level used designations for MYLK

kinase related protein, telokin , myosin, light chain kinase , myosin light chain kinase , myosin light chain kinase, smooth muscle-like , kinase-related protein , myosin light chain kinase, smooth muscle , myosin, light polypeptide kinase , smooth muscle myosin light chain kinase , telokin , MLCK , smooth muscle myosin light chain kinase (61-kDa active fragment)

GENE ID SPECIES
460640 Pan troglodytes
488012 Canis lupus familiaris
715422 Macaca mulatta
100481263 Ailuropoda melanoleuca
4638 Homo sapiens
288057 Rattus norvegicus
338037 Bos taurus
396848 Sus scrofa
100009143 Oryctolagus cuniculus
443334 Ovis aries
396445 Gallus gallus
100714177 Cavia porcellus
107589 Mus musculus
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