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The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Additionally we are shipping MYLIP Proteins (7) and MYLIP Kits (1) and many more products for this protein.
Showing 10 out of 54 products:
Chicken Polyclonal MYLIP Primary Antibody for WB - ABIN2774705
Ohmura-Hoshino, Matsuki, Aoki, Goto, Mito, Uematsu, Kakiuchi, Hotta, Ishido: Inhibition of MHC class II expression and immune responses by c-MIR. in Journal of immunology (Baltimore, Md. : 1950) 2006
Data suggest inducible expression of IDOL is subject to robust, rapid regulation by process that is sensitive to deubiquitinase inhibition in human/mouse cell lines and primary human cells; transcriptional induction of IDOL leads to degradation of LDLR (show LDLR Antibodies).
Identify USP2 (show USP2 Antibodies) as a novel regulator of lipoprotein clearance owing to its ability to control ubiquitylation-dependent degradation of the LDLR (show LDLR Antibodies) by IDOL.
The study identified MARCH6 (show MARCH6 Antibodies) as a negative regulator of SREBP2 (show SREBF2 Antibodies)-mediated transcription and described an unexpected E3 circuit functionally linking MARCH6 (show MARCH6 Antibodies) and IDOL to limit uptake of low-density lipoprotein via the LDLR (show LDLR Antibodies) pathway.
IDOL N342S Variant, Atherosclerosis Progression and Cardiovascular Disorders in the Italian General Population.
study indicates that MYLIP p.N342S might be a pharmacogenetic marker for lipid-lowering therapy in patients with FH.
Liver-specific expression of dominant-active IDOL is associated with hypercholesterolemia and a marked elevation in atherosclerotic lesions in transgenic mice.
evidence for the existence of an LXR (show NR1H3 Antibodies)-IDOL-mediated internalization pathway for the LDLR (show LDLR Antibodies) that is distinct from that used for lipoprotein uptake
Results show that IDOL contributes to variation in circulating levels of LDL-C.
IDOL is recruited to plasma membrane by low-density lipoprotein receptor (LDLR (show LDLR Antibodies)), promotes LDLR (show LDLR Antibodies) internalization in the absence of clathrin or caveolae, and facilitates LDLR (show LDLR Antibodies) degradation by shuttling it into the multivesicular body protein-sorting pathway
MYLIP rs3757354 SNP is associated with serum TC, HDL-C and ApoAI levels in the Bai Ku Yao and Han populations. But the association is different between the two ethnic groups.
Estradiol-treatment led to impaired contractile function in male cardiomyocytes only, which was characterized by increased Mylip mRNA and protein levels, and decreased myosin regulatory light chain protein.
These data identify the IDOL-LDLR (show LDLR Antibodies) interaction as an evolutionarily conserved mechanism for the regulation of lipid uptake and suggest that this interaction could potentially be exploited for the pharmacologic modulation of lipid metabolism.
Data show that NPC1 (show NPC1 Antibodies) deficiency has a major impact on VLDL metabolism in Apoe (show APOE Antibodies)(-/-) mice through modulation of hepatic LDL-R protein levels, and a modest one on Pcsk9 (show PCSK9 Antibodies) and Idol induction.
Data show that the identification of VLDLR (show VLDLR Antibodies) and ApoER2 (show LRP8 Antibodies) as Idol(Mylip) targets suggests potential roles for this LXR (show NR1H3 Antibodies)-inducible E3 ligase in the central nervous system in addition to lipid metabolism.
study shows the LXR (show NR1H3 Antibodies)-Idol(Mylip)-LDLR (show LDLR Antibodies) axis defines a complementary pathway to sterol response element-binding proteins for sterol regulation of cholesterol uptake
The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein (MYLIP) is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth.
E3 ubiquitin-protein ligase MYLIP-A
, myosin regulatory light chain-interacting protein A
, myosin regulatory light chain interacting protein
, e3 ubiquitin-protein ligase MYLIP-like
, E3 ubiquitin ligase-inducible degrader of the low density lipoprotein receptor
, E3 ubiquitin-protein ligase MYLIP
, band 4.1 superfamily member BZF1
, cellular modulator of immune recognition (c-MIR)
, inducible degrader of the LDL-receptor
, myosin regulatory light chain-interacting protein