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Myosin VI Proteins (MYO6)

MYO6 encodes a protein involved intracellular vesicle and organelle transport, especially in the hair cell of the inner ear. Additionally we are shipping Myosin VI Antibodies (46) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MYO6 4646 Q9UM54
MYO6 17920  
Rat MYO6 MYO6 315840  
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Top Myosin VI Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

MYO6 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Mouse (Murine)

More Proteins for Myosin VI (MYO6) Interaction Partners

Fruit Fly (Drosophila melanogaster) Myosin VI (MYO6) interaction partners

  1. These observations support the notion that a major function of Myosin VI in the nerve terminal is tethering synaptic vesicles to proper sub-cellular location within the bouton

  2. These data demonstrate that generating an organized and functional actin (show ACTB Proteins) structure in this cell requires multiple activities coordinated by myosin VI.

  3. The androcam structure and its binding to the myosin VI structural (Insert 2) and regulatory (IQ) light chain sites are distinct from those of calmodulin (show CALM Proteins).

  4. data indicate that myosin V (show MYO5A Proteins) and VI, but not II, play related but distinct roles in regulating microtubule (MT)-based mitochondrial movement: they oppose, rather than complement, protracted MT-based movements and perhaps facilitate organelle docking

  5. MyoVI is required for border cell migration where it stabilizes E-cadherin (show CDH1 Proteins) and Arm.

  6. Myosin VI is crucial for correct cell morphology and maintenance of adhesive cellular contacts within epithelial cell layers.

  7. Myosin VI stabilizes a branched actin network in actin structures (cones) that mediate the separation of the syncytial spermatids. I

  8. The spatial and temporal expression of Myosin VI was examined by expressing a Green Fluorescent Protein tagged Myosin VI molecule, under the control of a Myosin VI-Gal4 (show LGALS4 Proteins) line.

  9. Data suggest that Echinoid mediates the dimerization of myosin VI/Jaguar in vivo which in turn regulates the reorganization and/or contraction of actin (show ACTB Proteins) filaments to control changes in cell shape.

  10. Miranda protein forms an apical crescent at interphase, but is ubiquitously localized at prophase in a Myosin-II-dependent manner.

Human Myosin VI (MYO6) interaction partners

  1. study indicates that MYO6 may play an important role in gastric cancer tumorigenesis and may serve as a potential therapeutic target in human gastric cancer.

  2. This study identified an isoform-specific regulatory helix, named the alpha2-linker, that defines specific conformations and hence determines the target selectivity of human myosin VI.

  3. Interaction of myosin VI and its binding partner DOCK7 plays an important role in NGF-stimulated protrusion formation in PC12 cells.

  4. Knockdown of myosin VI significantly suppressed melanoma cell viability and proliferation.

  5. Knockdown of MYO6 markedly reduced cell viability and colony formation, as well as suppressed cell cycle progression in breast cancer cells.

  6. MYO6 was highly expressed in hepatocellular carcinoma.

  7. MYO6 is crucial in maintaining cell cycle and cell growth of lung cancer cells.MYO6 is highly expressed in human lung cancer tissues.

  8. Optineurin binding to my (show OPTN Proteins)osin VI was also decreased in tissue lysates from sporadic amyotrophic lateral sclerosis spinal cords.

  9. we demonstrate that myosin VI and TAX1BP1 (show TAX1BP1 Proteins) are recruited to ubiquitylated Salmonella and play a key role in xenophagy

  10. The frameshift deletion in MYO6 was confirmed as the causative variant for this dominant nonsyndromic hearing loss DFNA22 family

Mouse (Murine) Myosin VI (MYO6) interaction partners

  1. Myo1a (show MYO1A Proteins) and Myo6 play essential roles in response to intestinal mucosal injury

  2. Disruption in optineurin (show OPTN Proteins) and myosin VI-mediated cellular trafficking is associated with amyotrophic lateral sclerosis.

  3. We postulate that this novel interaction linking MVI with the PKA pathway could be important for targeting AKAP9-PKA complex within cells and/or providing PKA to phosphorylate MVI tail domain.

  4. Dysfunction of myosin VI is associated with slow retinal optic neuropathy and age-related macular degeneration.

  5. homologous pairing and myosin VI-mediated transcriptional pause release account for the rapid and efficient expression of genes induced by an external stimulus

  6. Myosin VI mediates the movement of NHE3 (show SLC9A3 Proteins) to the microvillus in intestinal epithelial cells.

  7. Report no change in cardiac myosin VI expression in mouse model of dilated cardiomyopathy.

  8. the Trip6-GRIP1-myosin VI interaction and its regulation on F-actin network play a significant role in dendritic morphogenesis

  9. Mutated Pou4f3 (show POU4F3 Proteins) has a negative role in the promoter activity of Myo6.

  10. homozygous Myo6(tvrm89) mice display reduced ERG a (show ERG Proteins)-wave and b-wave components, as well as components of the ERG (show ERG Proteins) attributed to RPE (show RPE Proteins) function, indicates that myosin 6 (show MYH6 Proteins) is necessary for the generation of proper responses of the outer retina to light.

Pig (Porcine) Myosin VI (MYO6) interaction partners

  1. Data suggest that cells direct the movement of vesicles around a cell by altering the relative number of myosin Va (show MYO5A Proteins) from Gallus gallus and myosin VI from Sus scrofa.

  2. A myosin VI deafness mutation, D179Y, uncoupled the release of the ATP hydrolysis product, inorganic phosphate (Pi), from dependency on actin binding and destroyed the ability of single dimeric molecules to move processively on actin filaments.

  3. model reveals that myosin VI, unlike plus-end directed myosins, does not use a pure lever arm mechanism, but instead steps with a mechanism analogous to the kinesin neck-linker uncoupling mode

  4. The stepping dynamics of single quantum-dot-labeled myoV and myoVI motors linked to a common cargo, was studied.

  5. These results suggest that myosin VI kinetics are tuned such that the motor maintains a consistent level of mechanical tension within the cell, a property potentially shared by other mechanosensitive proteins.

  6. a mechanism is proposed of myosin VI stepping that predicts a regulation through load of the motor's roles as transporter and anchor

  7. 2.4-A structure of a truncated version of the reverse-direction myosin motor, myosin VI, that contains the motor domain and binding sites for two calmodulin (show CALM Proteins) molecules

  8. Data demonstrate that full-length myosin VI is capable of forming stable, processive dimers when monomers are clustered, which move up to 1-2 mum in approximately 30 nm, hand-over-hand steps.

  9. further adaptations within the motor increase the magnitude and variability of the plus-end directed converter movements, and unexpectedly provide the source of the highly variable myosin VI step size

  10. Results suggest that myosin VI and vinculin (show VCL Proteins) form a molecular apparatus that generates cohesive cell-cell contacts in cultured mammalian epithelia.

Cow (Bovine) Myosin VI (MYO6) interaction partners

  1. MVI, but not myosins IB or IIB, was detected in chromaffin granules isolated from bovine medulla and found to be tightly associated with the granule apical surface.

Myosin VI (MYO6) Protein Profile

Protein Summary

This gene encodes a protein involved intracellular vesicle and organelle transport, especially in the hair cell of the inner ear. Mutations in this gene have been found in patients with non-syndromic autosomal dominant and recessive hearing loss.

Gene names and symbols associated with Myosin VI Proteins (MYO6)

  • jaguar (jar)
  • myosin VI (LOC373230)
  • myosin VI (LOC100223124)
  • myosin VI (LOC100351334)
  • myosin VI (myo6)
  • myosin VI (MYO6)
  • myosin VI (Myo6)
  • 95F protein
  • 95F MHC protein
  • BC029719 protein
  • CG5695 protein
  • CMY6 protein
  • DFNA22 protein
  • DFNB37 protein
  • Dm95F protein
  • Dm 95F protein
  • Dmel\\CG5695 protein
  • Dro95F protein
  • jag protein
  • Jaguar protein
  • Jar protein
  • M6 protein
  • Mhc95F protein
  • ms(3)06746 protein
  • myosins VI protein
  • Myosin VI protein
  • MyoVI protein
  • RGD1560646 protein
  • sv protein
  • Tlc protein

Protein level used designations for Myosin VI Proteins (MYO6)

95F myosin , 95F unconventional myosin , CG5695-PB , CG5695-PG , CG5695-PH , CG5695-PI , CG5695-PJ , CG5695-PK , CG5695-PL , CG5695-PM , jar-PB , jar-PG , jar-PH , jar-PI , jar-PJ , jar-PK , jar-PL , jar-PM , myosin 95F , myosin VI , myosin heavy chain , myosin heavy chain at 95F , myosin-VI , unconventional myosin VI , unconventional myosin-6 , unconventional myosin-VI , Snell's waltzer , tailchaser , unconventional myosin

42889 Drosophila melanogaster
373230 Strongylocentrotus purpuratus
100223124 Taeniopygia guttata
100351334 Oryctolagus cuniculus
100554995 Anolis carolinensis
100588526 Nomascus leucogenys
4646 Homo sapiens
17920 Mus musculus
315840 Rattus norvegicus
395487 Gallus gallus
397085 Sus scrofa
481884 Canis lupus familiaris
535127 Bos taurus
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