Myostatin Proteins (MSTN)

The protein encoded by MSTN is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. Additionally we are shipping Myostatin Antibodies (270) and Myostatin Kits (83) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MSTN 2660 O14793
MSTN 17700 O08689
MSTN 29152 O35312
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Top Myostatin Proteins at antibodies-online.com

Showing 10 out of 74 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Nicotiana benthamiana Human His tag SDS-PAGE analysis of recombinant Myostatin. Samples were loaded in 15 % SDS-polyacrylamide gel and stained with Coomassie blue. Lane MWM: Molecular weight marker (kDa), lane 1-3 contain 2.5, 1.25 and 0.25 µg of rhuman Myostatin Immune-detection with specific anti-human Myostatin IgG by WB Western Blot. Lane MWM: Molecular weight marker (kDa), lane 1-3 contains 2.5, 1.25 and 0.25 µg of rhuman Myostatin. 100 μg Log in to see 7 to 9 Days
$404.25
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 4 to 6 Days
$638.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated Validation with Western Blot 25 μg Log in to see 12 to 15 Days
$229.85
Details
HOST_Human Cells Mouse Fc Tag 10 μg Log in to see 20 to 21 Days
$250.80
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 2 to 3 Days
$495.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 10 μg Log in to see 3 to 4 Days
$85.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   10 μg Log in to see 6 to 8 Days
$328.21
Details
HOST_Mammalian Cells Mouse His tag   50 μg Log in to see 4 Days
$548.63
Details

MSTN Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , , ,
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Mouse (Murine) , , , , ,
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Rat (Rattus) , ,
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More Proteins for Myostatin (MSTN) Interaction Partners

Zebrafish Myostatin (MSTN) interaction partners

  1. improving muscle growth in a fish species by mixing a classical strategy, such as compensatory growth, and a biotechnological approach, such as the use of recombinant proteins for inhibiting the biological actions of MSTN(Myostatin)

  2. the expression of myostatin during development and the effects of its knock-down on various genes such as muscle regulatory transcription factors (MRFs), muscle-specific (show EIF3K Proteins) proteins (MSP (show MST1 Proteins)), and insulin (show INS Proteins)-like growth factors (IGFs).

  3. Epistatic analyses suggest a possible genetic interaction between Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) and Myostatin in regulation of slow and fast twitch muscle myofibrillogenesis

Medaka Myostatin (MSTN) interaction partners

  1. TALENs-mediated gene disruption of myostatin produces a larger phenotype of medaka with an apparently compromised immune system

  2. Findings suggest that myostatin (MSTN) function is required for regulating the appropriate growth of skeletal muscle in medaka

Human Myostatin (MSTN) interaction partners

  1. Serum myostatin levels were significantly decreased in heart failure patients and associated with lower extremity muscle wasting.

  2. our data showed a virtual absence of the variant (K) allele in MSTN rs1805086 in Japanese population, and no differences in allele/genotype frequencies in ACTN3 (show ACTN3 Proteins) rs1815739 among centenarians and healthy controls of this country.

  3. MSTN, but not GDF11 (show GDF11 Proteins), declines in healthy men throughout aging.

  4. Multivariate regression analysis revealed that myostatin levels correlated significantly with tricuspid annular plane systolic excursion values and right ventricle myocardial performance index among the study patients

  5. Study measured circulating myostatin levels in seven inherited muscle diseases using an immunoaffinity LC-MS/MS approach, found significantly lower serum myostatin concentrations in numerous muscle disease patient populations and the associations with clinical measurements suggests the potential utility of myostatin as a biomarker of genetic muscle disease progression

  6. data indicated that serum myostatin concentration did not correlate with muscle and bone mass in postmenopausal women

  7. Myostatin mRNA expression in skeletal muscle was significantly reduced compared with pre-exercise values at all time points with no difference between exercise intensity.

  8. Low expression of serum MSTN is associated with Cachexia Prevention in Patients with Medullary Thyroid Cancer.

  9. Myostatin was differentially expressed in the muscle and adipose tissue in relation to physical activity and dysglycaemia

  10. Our results suggest that serum levels of myostatin and irisin (show FNDC5 Proteins) are related in patients with type 2 diabetes

Mouse (Murine) Myostatin (MSTN) interaction partners

  1. These results demonstrate that a greater than additive effect is observed on the growth of skeletal muscle and in the reduction of body fat when myostatin is absent and IGF1 (show IGF1 Proteins) is in excess (show RCC1 Proteins), and that myostatin and IGF1 (show IGF1 Proteins) regulate skeletal muscle size, myofibre type and gonadal fat through distinct mechanisms.

  2. Mstn deficiency but not anti-myostatin blockade induces marked proteomic changes in mouse skeletal muscle.

  3. GDF8 plays a significant regulatory role in bone formation and bone resorption

  4. Genetic inactivation of myostatin increases maximal force and power, but in return it reduces muscle quality, particularly in male mice.

  5. findings indicate that myostatin directly influences osteocyte function and thereby inhibits osteoblastic differentiation, at least in part, through the suppression of osteocyte-derived exosomal miR (show MLXIP Proteins)-218, suggesting a novel mechanism in muscle-bone communication.

  6. The 12-bp Mstn(Cmpt-dl1Abc) deletion decreases adiposity and improves whole body glucose uptake, insulin (show INS Proteins) sensitivity, and (18)FDG (show SMUG1 Proteins) uptake of skeletal muscle and white adipose tissue.

  7. In this model, increased LTBP4 led to greater muscle mass with proportionally increased strength, and decreased fibrosis. The increase in muscle mass and reduction in fibrosis were similar to what occurs when myostatin, a related TGFbeta (show TGFB1 Proteins) family member and negative regulator of muscle mass, was deleted in mdx (show DMD Proteins) mice

  8. myostatin dysfunction impairs adaptation of the soleus muscle to high functional demands.

  9. Evidences indicate that the suppression of MSTN cause to increase the regenerative potential of injured soleus muscle via the increase in the population of muscle satellite cells regardless of unloading conditions.

  10. A role for Nfix (show MLZE Proteins) in postnatal skeletal muscle development and regeneration and Myostatin gene expression regulation.

Pig (Porcine) Myostatin (MSTN) interaction partners

  1. These results indicate that myostatin mediates maternal low protein diet-induced growth retardation, through epigenetic regulation involving FoxO3 (show FOXO3 Proteins) and glucocorticoid receptor (show NR3C1 Proteins) binding to its promoter.

  2. Loss of MSTN increases muscle mass in pigs, which may help increase pork production for consumption in the future.

  3. Data show that the protein level of The protein level of myostatin (MSTN) was decreased in the mutant cloned pigs compared with the wild-type controls.

  4. Single nucleotide polymorphisms in the MYOD1 (show MYOD1 Proteins) and GDF8 genes are associated with genetic transcription during myogenesis in pigs.

  5. The level of myostatin inversely correlated with miR (show MYLIP Proteins)-27a in fat and heart of pigs and also in proliferating porcine myoblasts. Overexpression of miR (show MYLIP Proteins)-27a in porcine myoblasts promoted cell proliferation by reducing the expression of myostatin.

  6. MSTN g.435G>A and g.447A>G affected carcass traits in pigs

  7. The genotypes of MSTN g.435G > A and g.447A > G SNPs in Duroc pigs were studied. The 435GG/447AA (show COL16A1 Proteins) individually had significantly higher average daily gain, body weight at 70 d and 150 d , and a lower age at 110 kg than 435AA/447GG individuals.

  8. Porcine MSTN could be upregulated by isobutyl-1-methylxanthine , MyoD (show MYOD1 Proteins), and PPARgamma (show PPARG Proteins) but downregulated by C/EBPalpha (show CEBPA Proteins) and C/EBPbeta (show CEBPB Proteins).

  9. a vital enhancer region was identified between nucleotides -218 and -137 in promoter region of porcine myostatin

  10. It was concluded that myostatin is a factor broadly expressed in the internal organs and muscle tissues of pigs.

Cow (Bovine) Myostatin (MSTN) interaction partners

  1. Data indicate that the the promoter trap vector PIII-myostatin could knock out the bovine myostatin gene.

  2. The effects of myostatin and myogenic factor 5 (show MYF5 Proteins) polymorphisms on growth and muscle traits of Marchigiana breed were assessed.

  3. we demonstrate zygote injection of TALEN mRNA can also produce gene-edited cattle and sheep. In both species we have targeted the myostatin (MSTN) gene.

  4. proof-of-concept study is the first to produce MSTN mutations in cattle, and may allow the development of genetically modified strains of double-muscled cattle.

  5. Mutations in the leader peptide of the bovine myostatin gene effectively promote the proliferation of bovine fibroblast cells.

  6. there were 18 SNPs identified in the Qinchuan cattle promoter region compared with those of other cattle compared to the Red Angus cattle myostatin promoter region.

  7. A 3-way interaction of myostatin genotype (MG), season, and trigonometric function periodicities of 24 h and 12 h indicate that a genotype x environment interaction exists for MG.

  8. These results show for the first time that myostatin regulates the differential expression of chemokines in skeletal muscle cells.

  9. bovine myostatin is a specific target of miR (show MYLIP Proteins)-27b and that miRNAs contribute to explain additive phenotypic hypertrophy in Piedmontese cattle selected for the MSTN gene mutation

  10. Mutations in the myostatin gene, responsible for the double muscling condition in cattle, were targeted to estimate the time since the most recent common ancestor. Each myostatin allele had a recent common ancestor (<400 years ago).

Goat Myostatin (MSTN) interaction partners

  1. The reduced expression of myostatin gene was achieved and measured in clonal fibroblast cells by real-time PCR.

  2. This study also suggests the importance of siRNA-mediated knockdown of MSTN as a potential alternative to increase muscle mass and meat production.

  3. A study of the MSTN 5' upstream region and investigation of 5'UTR TTTTA deletion was carried out in seven different Indian goat breeds. An 1181 bp fragment of 5' upstream region of MSTN gene was PCR amplified, cloned, and sequenced.

  4. myostatin plays a negative role in regulating the expression of adipogenesis related genes in goat fetal fibroblasts.

  5. Polymorphisms of myostatin gene as markers associated with growth in Boer goats.

Horse (Equine) Myostatin (MSTN) interaction partners

  1. The effect of an Equine Repetitive Element 1 insertion in the promoter of the myostatin gene, which is involved in muscle development, was also investigated.

  2. Myostatin mRNA but not protein was increased in skeletal muscle of obese compared with lean animals. Myostatin mRNA was increased in crest fat of obese animals and protein was undetectable. Serum myostatin was higher in obese than lean animals.

  3. The tissue-specific presence of myostatin, the moystatin receptor (activin receptor IIB (show ACVR2B Proteins), ActRIIB (show ACVR2B Proteins)), follistatin (show FST Proteins) and perilipin (show PLIN1 Proteins), genes and proteins across a range of equine tissues, were examined.

  4. The candidate for racing performance genomic region contained eight genes annotated by ENSEMBL, including the myostatin gene (MSTN).

  5. Polymorphisms of the MSTN promoter region in 5 horse breeds in Poland are reported.

  6. significant association observed between genotype and mRNA abundance for untrained horses with the C/C cohort having highest MSTN mRNA levels,T/T group lowest levels and C/T group intermediate levels; following training there was significant decrease in MSTN mRNA which was most apparent for the C/C cohort

  7. Exon 2 of the MSTN gene, which encodes part of the TGF-beta (show TGFB1 Proteins) pro-peptide, was sequenced in 332 horses of 20 different breeds and compared with the horse MSTN gene sequence deposited in GenBank. The sequences obtained revealed the presence of 11 haplotypes represented by 10 variable nucleotide mutations, eight of them corresponding to amino acid sequence changes.

  8. Variation at the MSTN gene influences speed in Thoroughbred horses.

  9. This study demonstrates that the g.66493737C>T single nucleotide polymorphism in MSTN provides the most powerful genetic marker for prediction of race distance aptitude in Thoroughbreds.

  10. Characterized the horse (Equus caballus) MSTN gene and identified and analysed single nucleotide polymorphisms (SNPs) in breeds of different morphological types.

Rabbit Myostatin (MSTN) interaction partners

  1. Alignment of sequence data with the GenBank sequence of the rabbit MSTN gene identified three single nucleotide polymorphisms (SNPs). Significant linkage was found between the novel SNP c.373+234G>A and nine carcass composition traits.

  2. These results suggest that the mutations in the upstream regulatory region of the MSTN gene are beneficial to the rabbit soma development, and the mutations can be used as molecular markers for the selection of the meat quality of rabbits.

  3. Studied and compared mRNA levels of myostatin (MSTN), myogenin (MyoG (show MYOG Proteins)), and myosin heavy chain (MyHC) in skeletal muscles of two rabbit breeds with different body sizes and growth rates.

  4. indicated that MSTN is not an important source of variability for performance traits, at least in the rabbit population

Myostatin (MSTN) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth.

Gene names and symbols associated with Myostatin Proteins (MSTN)

  • myostatin (MSTN)
  • myostatin b (mstnb)
  • myostatin (AaeL_AAEL003224)
  • myostatin (BRAFLDRAFT_290840)
  • myostatin (Mstn)
  • myostatin (mstn)
  • myostatin (LOC100125998)
  • Cmpt protein
  • GDF-8 protein
  • Gdf8 protein
  • MSLHP protein
  • mstn protein
  • NV13143 protein
  • zgc:109749 protein

Protein level used designations for Myostatin Proteins (MSTN)

Growth/differentiation factor 8 , growth/differentiation factor-8 , GDF-8 , growth differentiation factor 8 , growth/differentiation factor 8 , mstn-1 , myostatin-1 , myostatin-B , zfMSTN-1 , myostatin , compact

GENE ID SPECIES
100303659 Meleagris gallopavo
798441 Danio rerio
5577632 Aedes aegypti
7221321 Branchiostoma floridae
100118233 Nasonia vitripennis
100379652 Ictalurus punctatus
100529165 Oryzias latipes
2660 Homo sapiens
17700 Mus musculus
29152 Rattus norvegicus
373964 Gallus gallus
399534 Sus scrofa
281187 Bos taurus
403433 Canis lupus familiaris
100860887 Capra hircus
100033832 Equus caballus
443449 Ovis aries
100735599 Cavia porcellus
100125998 Oryctolagus cuniculus
710114 Macaca mulatta
100968757 Pan paniscus
470605 Pan troglodytes
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