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Myristoylated Alanine-Rich Protein Kinase C Substrate Proteins (MARCKS)

The protein encoded by MARCKS is a substrate for protein kinase C. Additionally we are shipping MARCKS Antibodies (228) and MARCKS Kits (17) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MARCKS 17118 P26645
MARCKS 25603  
MARCKS 4082 P29966
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Top MARCKS Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,735.33
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,821.50
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,896.67
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

MARCKS Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus)

Human , ,
,

More Proteins for Myristoylated Alanine-Rich Protein Kinase C Substrate (MARCKS) Interaction Partners

Xenopus laevis Myristoylated Alanine-Rich Protein Kinase C Substrate (MARCKS) interaction partners

  1. The results indicated MARCKS may be the missing link in the regulation of the function (i.e., sodium transport) of epithelial sodium channels by anionic phospholipids.

Mouse (Murine) Myristoylated Alanine-Rich Protein Kinase C Substrate (MARCKS) interaction partners

  1. Conditional deletion of MARCKS in ECs induces intracellular accumulation of mucins, elevated oxidative stress, and lipid droplet buildup.

  2. MARCKS acts as a "molecular switch," binding to and regulating PIP2 signaling to regulate processes like proplatelet extension (microtubule-driven) vs proplatelet branching (Arp2/3 and actin polymerization-driven).

  3. MARCKS knockdown arrested VSMC cell cycle by decreasing KIS (show UHMK1 Proteins) expression. Decreased KIS (show UHMK1 Proteins) expression resulted in nuclear trapping of p27kip1 (show CDKN1B Proteins) in VSMCs.

  4. MARCKS regulates the expression of proinflammatory cytokines in macrophages through activation of p38 (show CRK Proteins)/JNK (show MAPK8 Proteins) MAPK (show MAPK1 Proteins) and NF-kappaB (show NFKB1 Proteins).

  5. Targeting phospho-MARCKS overcomes drug-resistance and induces antitumor activity in preclinical models of multiple myeloma.

  6. Grin 1 is identified as a novel Cdk5 (show CDK5 Proteins) substrate and MARCKS is confirmed as a Cdk5 (show CDK5 Proteins) substrate.

  7. MARCKS appears to be a nonessential regulatory protein in mast cell exocytosis but exerts a negative modulation.

  8. MARCKS overexpression in the hippocampus of old mice leads to long-term potentiation and improved memory.

  9. an important functional role for the interaction between MARCKS and PSA (show NPEPPS Proteins) in the developing and adult nervous system.

  10. cathepsin K (show CTSK Proteins) exocytosis is controlled by PKCdelta (show PKCd Proteins) through modulation of the actin bundling protein myristoylated alanine-rich C-kinase substrate.

Zebrafish Myristoylated Alanine-Rich Protein Kinase C Substrate (MARCKS) interaction partners

  1. Marcksb is required for proper gastrulation movements of zebrafish.

Human Myristoylated Alanine-Rich Protein Kinase C Substrate (MARCKS) interaction partners

  1. Knockdown of MARCKS in HepG2 cells reduced cell migration and invasion, but not cell proliferation.

  2. MARCKS upregulation increases vascular smooth muscle cell motility by activation of Rac1 and Cdc42 (show CDC42 Proteins), promoting neointima formation.

  3. A novel role for MARCKS in regulating nuclear functions such as gene expression.

  4. MARCKS knockdown arrested VSMC cell cycle by decreasing KIS (show UHMK1 Proteins) expression. Decreased KIS (show UHMK1 Proteins) expression resulted in nuclear trapping of p27kip1 (show CDKN1B Proteins) in VSMCs.

  5. unresponsiveness of breast cancer to paclitaxel treatment is, at least in part, mediated by phospho-MARCKS

  6. MARCKS and PPP1R9A might contribute to spine loss in schizophrenia and bipolar disorder through their interactions.

  7. isotype delta-PKC (show PRRT2 Proteins) is responsible for myristoylated alanine-rich C-kinase substrate (MARCKS) phosphorylation in human neutrophils following f-Met-Leu-Phe stimulation and MARCKS phosphorylation is essential for neutrophil migration and adhesion.

  8. A key role of the effector domain of MARCKS in terms of cellular response, particularly to radiation: the importance of MARCKS phosphorylation status for its subcellular localization in lung cancer.

  9. MARCKS overexpression was observed in several drug-resistant human myeloma cell lines and in drug-resistant primary multiple myeloma samples.

  10. Finding that MARCKS acts as a mediator of apoptosis in microsatellite stable colorectal cancer cells adds a novel tumor-suppressing function to the established roles of MARCKS in cell motility and proliferation.

Cow (Bovine) Myristoylated Alanine-Rich Protein Kinase C Substrate (MARCKS) interaction partners

  1. MARCKS protein mediates hydrogen peroxide regulation of endothelial permeability.

  2. a critical role for H(2)O(2) in angiotensin-II signaling to the endothelial cytoskeleton in a novel pathway that is critically dependent on MARCKS, Rac1, and c-Abl.

  3. These findings demonstrate a critical role for MARCKS-phosphatidylinositol-4,5-diphosphate signaling in regulating dendrite development.

  4. Protein kinase C mediated inhibition of endothelial L-arginine (show GATM Proteins) transport is mediated by MARCKS protein

MARCKS Protein Profile

Protein Summary

The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis.

Gene names and symbols associated with MARCKS

  • myristoylated alanine-rich protein kinase C substrate (marcks)
  • myristoylated alanine-rich protein kinase C substrate (MARCKS)
  • myristoylated alanine-rich protein kinase C substrate (LOC100345174)
  • methyl binding domain (mbd106)
  • myristoylated alanine rich protein kinase C substrate (marcks)
  • myristoylated alanine rich protein kinase C substrate (Marcks)
  • myristoylated alanine rich protein kinase C substrate b (marcksb)
  • 80K-L protein
  • KINC protein
  • MACS protein
  • MARCKS protein
  • MGC89127 protein
  • PKCSL protein
  • PRKCSL protein
  • wu:fb55c06 protein
  • wu:fb92d04 protein
  • wu:fc19b04 protein
  • wu:fc44a10 protein
  • zgc:110235 protein

Protein level used designations for MARCKS

myristoylated alanine-rich protein kinase C substrate , methyl binding domain , Zmmbd2 , PCO124731 , PCO124731_ov , myristoylated alanine-rich C-kinase substrate , Myristoylated alanine-rich protein kinase C substrate , protein kinase C substrate 80 kDa protein , myristoylated alanine-rich protein kinase C substrate (MARCKS, 80K-L) , phosphomyristin , protein kinase C substrate, 80 kDa protein, light chain , myristoylated alanine-rich C kinase substrate (MARCKS) , ACAMP-81

GENE ID SPECIES
448317 Xenopus (Silurana) tropicalis
694077 Macaca mulatta
742020 Pan troglodytes
100345174 Oryctolagus cuniculus
542069 Zea mays
379767 Xenopus laevis
17118 Mus musculus
25603 Rattus norvegicus
323201 Danio rerio
4082 Homo sapiens
396473 Gallus gallus
613548 Bos taurus
612436 Canis lupus familiaris
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