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N6AMT1 encodes protein methyltransferase. Additionally we are shipping N6AMT1 Antibodies (57) and many more products for this protein.
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AS3MT (show AS3MT Proteins) and N6AMT1 polymorphisms and urinary arsenic metabolites (%iAs, %MMA (show MMD Proteins), %DMA (show HLA-DMA Proteins)) in 722 subjects from an arsenic-cancer case-control study in a uniquely exposed area in northern Chile, were examined.
Five N6AMT1 single nucleotide polymorphisms and two N6AMT1 haplotypes were significantly associated with the percentage of methylarsonic acid in urine, even after adjusting for arsenic (+3 oxidation state) methyltransferase (show AS3MT Proteins) haplotype.
N6AMT1 converted monomethylarsonous acid to dimethylarsonic acid when overexpressed in UROtsa human urothelial cells. It is expressed in many human tissues at variable levels, supporting a potential participation in arsenic metabolism in vivo.
The human HemK2 protein methylates human and yeast eRF1 (show ZFP36L1 Proteins).eRF3.GTP (show AK3 Proteins) in vitro, and that the methyltransferase catalytic subunit can complement the growth defect of yeast strains deleted for mtq2.
HEMK2 requires a GQX3R motif for methylation activity.
Disruption of N6amt1 gene led to early embryonic lethality.
The murine PRED28 encodes two alternatively spliced RNA.
suggested that mN6A1 participates in protein translation through interaction with eRF1 (show ZFP36L1 Proteins)
This gene encodes protein methyltransferase. The encoded enzyme may be involved in the methylation of release factor I during translation termination. This enzyme is also involved in converting the arsenic metabolite monomethylarsonous acid to the less toxic dimethylarsonic acid. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 11.
N-6 adenine-specific DNA methyltransferase 1 (putative)
, HemK methyltransferase family member 2
, hemK methyltransferase family member 2
, n(6)-adenine-specific DNA methyltransferase 1
, M-N6DNA MTase A
, N6-DNA methyltransferase A
, N(6)-adenine-specific DNA methyltransferase 1