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anti-N-Acetylglucosamine-1-phosphodiester alpha-N-Acetylglucosaminidase (NAGPA) Antibodies

Hydrolases are transported to lysosomes after binding to mannose 6-phosphate receptors in the trans-Golgi network. Additionally we are shipping NAGPA Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
NAGPA 51172 Q9UK23
NAGPA 27426 Q8BJ48
NAGPA 360476  
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Top anti-NAGPA Antibodies at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (37.11 KDa) . 50 μL Log in to see 9 Days
$298.57
Details
Human Rabbit Un-conjugated WB   50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated IHC, IHC (p)   0.1 mL Log in to see 8 to 11 Days
$483.66
Details

NAGPA Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human
,

Mouse (Murine)


Rat (Rattus)


More Antibodies against NAGPA Interaction Partners

Human N-Acetylglucosamine-1-phosphodiester alpha-N-Acetylglucosaminidase (NAGPA) interaction partners

  1. SNPs covering GNPTAB (show GNPTAB Antibodies), GNPTG (show GNPTG Antibodies) and NAGPA were subjected to genotyping, association analysis was performed on all SNPs. Significant association of rs17031962 in GNPTAB (show GNPTAB Antibodies) and rs882294 in NAGPA with developmental dyslexia in a Chinese population was identified after false discovery rate correction for multiple comparisons.

  2. To date mutations in GNPTAB (show GNPTAB Antibodies), GNPTG (show GNPTG Antibodies), and NAGPA have been associated with stuttering. These genes encode the lysosomal enzyme targeting pathway, defective in mucolipidosis. (Review)

  3. Analysis of mannose 6-phosphate uncovering enzyme mutations associated with persistent stuttering.

  4. identified three mutations in the NAGPA gene associated with stuttering

  5. synthesis as a proenzyme that is activated by furin (show FURIN Antibodies) [mannose 6-phosphate-uncovering enzyme]

  6. The mannose 6-phosphate uncovering enzyme participates in the uncovering of the mannose 6-phosphate recognition tag on lysosomal enzymes, a process that facilitates recognition of those enzymes by mannose 6-phosphate receptors to delivery to lysosomes.

Mouse (Murine) N-Acetylglucosamine-1-phosphodiester alpha-N-Acetylglucosaminidase (NAGPA) interaction partners

  1. UCE -/- mice were viable, grew normally & lacked detectable histologic abnormalities, but plasma levels of 6 acid hydrolases were elevated. UCE accounts for all the uncovering activity in the Golgi.

NAGPA Antigen Profile

Protein Summary

Hydrolases are transported to lysosomes after binding to mannose 6-phosphate receptors in the trans-Golgi network. This gene encodes the enzyme that catalyzes the second step in the formation of the mannose 6-phosphate recognition marker on lysosomal hydrolases. Commonly known as 'uncovering enzyme' or UCE, this enzyme removes N-acetyl-D-glucosamine (GlcNAc) residues from GlcNAc-alpha-P-mannose moieties and thereby produces the recognition marker. This reaction most likely occurs in the trans-Golgi network. This enzyme functions as a homotetramer of two disulfide-linked homodimers. In addition to having an N-terminal signal peptide, the protein's C-terminus contains multiple signals for trafficking it between lysosomes, the plasma membrane, and trans-Golgi network.

Gene names and symbols associated with NAGPA

  • N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (NAGPA) antibody
  • N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (NAEGRDRAFT_56913) antibody
  • N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (Nagpa) antibody
  • AI596180 antibody
  • APAA antibody
  • NAGPA antibody
  • UCE antibody

Protein level used designations for NAGPA

N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase , alpha-N-acetylglucosaminyl phosphodiesterase , lysosomal alpha-N-acetylglucosaminidase , mannose 6-phosphate-uncovering enzyme , phosphodiester alpha-GlcNAcase , alpha-GlcNAcase

GENE ID SPECIES
416395 Gallus gallus
490019 Canis lupus familiaris
8849914 Naegleria gruberi strain NEG-M
100399724 Callithrix jacchus
51172 Homo sapiens
27426 Mus musculus
360476 Rattus norvegicus
515935 Bos taurus
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