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N-Acetylglutamate Synthase Proteins (NAGS)

The N-acetylglutamate synthase gene encodes a mitochondrial enzyme that catalyzes the formation of N-acetylglutamate (NAG) from glutamate and acetyl coenzyme-A. Additionally we are shipping NAGS Antibodies (14) and NAGS Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NAGS 162417 Q8N159
NAGS 217214 Q8R4H7
Rat NAGS NAGS 303563  
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Top NAGS Proteins at antibodies-online.com

Showing 10 out of 25 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Azotobacter His tag   1 mg Log in to see 56 to 66 Days
$3,206.50
Details
Yeast Pseudomonas putida His tag   1 mg Log in to see 56 to 66 Days
$3,206.50
Details
Yeast Pseudomonas syringae His tag   1 mg Log in to see 56 to 66 Days
$3,206.50
Details
Yeast Haemophilus ducreyi His tag   1 mg Log in to see 56 to 66 Days
$3,223.00
Details
Yeast Actinobacillus succinogenes His tag   1 mg Log in to see 56 to 66 Days
$3,232.17
Details
Yeast Pasteurella multocida His tag   1 mg Log in to see 56 to 66 Days
$3,232.17
Details
Yeast REACT_Yersinia pseudotuberculosis His tag   1 mg Log in to see 56 to 66 Days
$3,234.00
Details

NAGS Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for N-Acetylglutamate Synthase (NAGS) Interaction Partners

Human N-Acetylglutamate Synthase (NAGS) interaction partners

  1. Data indicate the formation of alternative N-acylglutamates by N-acetylglutamate synthase (NAGS).

  2. Sp1 (show PSG1 Proteins), CREB (show CREB1 Proteins), HNF-1 (show HNF1A Proteins), and NF-Y, known to be responsive to hormones and diet, regulate NAGS transcription

  3. NAGS deficiency in humans leads to hyperammonemia and can be primary, due to mutations in the NAGS gene or secondary due to other mitochondrial aberrations that interfere with the normal function of the same enzyme.

  4. After the human NAGS gene was identified, mutation analysis revealed that the older sibling on NCG therapy was homozygous for a 971G>A (W324X) mutation.

  5. The first mutation in NAGS has been reported in a family with carbamylglutamate responsive hyperammonemia and normal activity of the urea cycle enzymes.

  6. Gene product expressed in E. coli shown to have NAGS enzyme activity. Gene name provisionally was assigned as NAT7.

  7. report two deleterious mutations within the NAGS gene found in two families with infants presenting with acute neonatal disease; finding confirms the genetic origin of NAGS deficiency

  8. first report of mutation analysis in a series of families affected with deficiency of NAGS

  9. 3 mutations in 2 families with NAGS deficiency revealed deleterious effects on NAGS affinity for substrates & the rate of catalysis.

  10. Three novel mutations in the NAGS gene from the families affected by autosomal recessively inherited NAGS deficiency were described and characterized.

Pig (Porcine) N-Acetylglutamate Synthase (NAGS) interaction partners

  1. The intestinal NAGS mRNA levels were lower in 7- to 28-day-old than in 1-day-old pigs. Immunochemical analysis revealed that NAGS protein was localized in enterocytes of the gut (show GUSB Proteins).

Mouse (Murine) N-Acetylglutamate Synthase (NAGS) interaction partners

  1. Sp1 (show SP1 Proteins), CREB (show CREB1 Proteins), HNF-1 (show HNF1A Proteins), and NF-Y, known to be responsive to hormones and diet, regulate NAGS transcription

  2. Is a mitochondrial enzyme that catalyzes the formation of N-acetylglutamate (NAG)

  3. The biochemical properties of purified recombinant human and mouse NAGS-M and NAGS-C were determined in this study with the goal of better understanding the role of the variable domain in NAGS function.

NAGS Protein Profile

Protein Summary

The N-acetylglutamate synthase gene encodes a mitochondrial enzyme that catalyzes the formation of N-acetylglutamate (NAG) from glutamate and acetyl coenzyme-A. NAG is a cofactor of carbamyl phosphate synthetase I (CPSI), the first enzyme of the urea cycle in mammals. This gene may regulate ureagenesis by altering NAG availability and, thereby, CPSI activity. Deficiencies in N-acetylglutamate synthase have been associated with hyperammonemia.

Gene names and symbols associated with NAGS

  • N-acetylglutamate synthase (argA)
  • N-acetylglutamate synthase (ECs3675)
  • N-acetylglutamate synthase (VP2371)
  • N-acetylglutamate synthase (Psyr_0254)
  • N-acetylglutamate synthase (Sde_0360)
  • N-acetylglutamate synthase (NAGS)
  • N-acetylglutamate synthase (Nags)
  • 1700120E20Rik protein
  • AGAS protein
  • argA protein
  • RGD1565783 protein
  • VF0585 protein

Protein level used designations for NAGS

N-acetylglutamate synthase , N-acetylglutamate synthase, mitochondrial , amino-acid acetyltransferase , amino-acid N-acetyltransferase

GENE ID SPECIES
879475 Pseudomonas aeruginosa PAO1
916513 Escherichia coli O157:H7 str. Sakai
957960 Escherichia coli O157:H7 str. EDL933
1109804 Buchnera aphidicola str. APS (Acyrthosiphon pisum)
1171849 Shewanella oneidensis MR-1
1178706 Vibrio vulnificus CMCP6
1189884 Vibrio parahaemolyticus RIMD 2210633
2765021 Yersinia pestis biovar Microtus str. 91001
2955212 Yersinia pseudotuberculosis IP 32953
3090331 Burkholderia mallei ATCC 23344
3181020 Aromatoleum aromaticum EbN1
3277126 Vibrio fischeri ES114
3365730 Pseudomonas syringae pv. syringae B728a
3480313 Pseudomonas protegens Pf-5
3964826 Saccharophagus degradans 2-40
4713614 Yersinia enterocolitica subsp. enterocolitica 8081
8165153 Photorhabdus asymbiotica subsp. asymbiotica ATCC 43949
162417 Homo sapiens
490943 Canis lupus familiaris
100048960 Sus scrofa
538004 Bos taurus
217214 Mus musculus
303563 Rattus norvegicus
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