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ASAH1 encodes a heterodimeric protein consisting of a nonglycosylated alpha subunit and a glycosylated beta subunit that is cleaved to the mature enzyme posttranslationally. Additionally we are shipping N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 Antibodies (67) and N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 Proteins (11) and many more products for this protein.
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Data suggest up-regulation of ASAH1 activity by androgen in androgen-sensitive prostate cancer cells (not other cancer cells) is due to prolonged stability of ASAH1 by androgen-stimulated induction of USP2 (ubiquitin specific peptidase 2 (show USP2 ELISA Kits)) expression.
Genetic or pharmacological acid ceramidase inhibition promotes cisplatin cytotoxicity in head and neck tumor cells.
high ASAH1 expression is generally associated with an improved prognosis in invasive breast cancer independent of adjuvant treatment and could also be valuable as prognostic factor for pre-invasive DCIS.
novel ASAH1 mutations affecting polypyrimidine tract deletion, and exon skipping and resulting in Farber lipogranulomatosis
Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt (show AKT1 ELISA Kits) signaling.
Depletion of both Akt2 (show AKT2 ELISA Kits) and ASAH1 is much more potent than depleting each alone at inhibiting neoplastic cell viability/proliferation and invasion.
This work unravels for the first time the mutations underlying the neonatal form of Farber disease and represents the first report of a large deletion identified in the ASAH1 gene.
Immunohistochemical analysis of human prostate cancer tissues revealed higher levels of ASAH1 after radiotherapy failure.
These observations confirm ASAH1 as a therapeutic target in advanced and chemoresistant forms of prostate cancer
Acid ceramidase is a prognostic factor in epithelial ovarian cancer
cells deficient in acid ceramidase (aCDase) also exhibited defects in CCL5 (show CCL5 ELISA Kits) induction, whereas cells deficient in sphingosine kinase-1 (show SPHK1 ELISA Kits) and -2 exhibited higher levels of CCL5 (show CCL5 ELISA Kits).
biochemistry of acid ceramidase reaction with acid sphingomyelinase (show SMPD1 ELISA Kits)
Acid and neutral sphingomyelinase (show SMPD2 ELISA Kits), ceramide synthase, and acid ceramidase have roles in cutaneous aging
These results provide the first characterization of the Acid Ceremidase promoter from any species and demonstrate that Kruppel-like factor 6 (KLF6 (show KLF6 ELISA Kits)) is one transcription factor involved in the regulation of AC gene expression.
acid ceramidase is an essential factor required for embryo survival that functions by removing ceramide from the newly formed embryos, thus inhibiting the default apoptosis pathway
This gene encodes a heterodimeric protein consisting of a nonglycosylated alpha subunit and a glycosylated beta subunit that is cleaved to the mature enzyme posttranslationally. The encoded protein catalyzes the synthesis and degradation of ceramide into sphingosine and fatty acid. Mutations in this gene have been associated with a lysosomal storage disorder known as Farber disease. Multiple transcript variants encoding several distinct isoforms have been identified for this gene.
N-acylsphingosine amidohydrolase (acid ceramidase) 1
, N-acylsphingosine amidohydrolase 1
, acid ceramidase
, acid CDase
, acylsphingosine deacylase
, putative 32 kDa heart protein
, Acylsphingosine deacylase