N-Ethylmaleimide-Sensitive Factor Proteins (NSF)

Required for vesicle-mediated transport. Additionally we are shipping NSF Antibodies (110) and NSF Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NSF 18195 P46460
NSF 60355 Q9QUL6
NSF 4905 P46459
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Top NSF Proteins at antibodies-online.com

Showing 8 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Escherichia coli (E. coli) Rat His tag   50 μg Log in to see 11 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
Escherichia coli (E. coli) Rat Un-conjugated   50 μg Log in to see 2 to 3 Days
Escherichia coli (E. coli) Human T7 tag,His tag 100 μg Log in to see 15 to 18 Days

NSF Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus) ,

Human , , ,
, , ,

More Proteins for N-Ethylmaleimide-Sensitive Factor (NSF) Interaction Partners

Xenopus laevis N-Ethylmaleimide-Sensitive Factor (NSF) interaction partners

  1. NSF- and SNARE (show NAPA Proteins)-mediated membrane fusion events are essential steps during Nuclear envelope formation downstream of Nup107 (show NUP107 Proteins) recruitment, and upstream of membrane flattening and completion of nuclear pore complex assembly.

Mouse (Murine) N-Ethylmaleimide-Sensitive Factor (NSF) interaction partners

  1. NSF may have a role in vascular instability in gram-positive lung infections

  2. that mutant LRRK2 (show LRRK2 Proteins) may impair synaptic vesicle dynamics via aberrant phosphorylation of N-ethylmaleimide sensitive fusion

  3. identify conserved sequences in the 3'UTR of NSF as miR (show MLXIP Proteins)-33 responsive elements and show that Nsf is specifically recruited to the RNA-induced silencing complex following induction of miR (show MLXIP Proteins)-33

  4. Arr1 (show SAG Proteins) and NSF interaction are necessary for both maintenance and modulation of normal photoreceptor synaptic regulation and NSF-RP2 (show RP2 Proteins) interaction may play an important role in membrane protein trafficking in the photoreceptor.

  5. These findings identify new roles for N-ethylmaleimide-sensitive factor and protein kinase C epsilon (show PRKCE Proteins) in regulating synaptic inhibition through downregulation of GABA(A) receptors

  6. interaction of AMPA (show GRIA3 Proteins) receptors with N-ethylmaleimide-sensitive factor plays a critical role in incorporation of AMPA (show GRIA3 Proteins) receptors into synapses and for their subsequent removal during cerebellar long term depression

  7. PICK1 (show PICK1 Proteins) and NSF dynamically regulate the synaptic delivery of GluR2 (show GRIA2 Proteins)-containing receptors during CARP (show ANKRD1 Proteins) and thus regulate the calcium permeability of AMPA (show GRIA3 Proteins) receptors at excitatory synapses.

  8. H(2)O(2) regulates exocytosis by inhibiting N-ethylmaleimide sensitive factor (NSF), a protein that regulates membrane fusion events necessary for exocytosis.

  9. important role for NSF activity in regulating the cell surface stability of GABA(A) receptors.

  10. dual regulation on hbeta2AR trafficking and signaling by NSF through direct binding to cargo receptor and its ATPase activity.

Human N-Ethylmaleimide-Sensitive Factor (NSF) interaction partners

  1. NSF deficiency in HeLa cells barely affected cell viability, anterograde trafficking of vesicular stomatitis virus glycoprotein G and transferrin (show Tf Proteins) endocytosis.

  2. a processive helicase-like mechanism for NSF in which approximately 1 residue is unwound for every hydrolyzed ATP molecule.

  3. Single and multiple-marker analyses revealed a strong association between cocaine dependence and the NSF gene.

  4. Knockdown of TRX1 (show MLL Proteins) increases the level of S-nitrosylated NSF, prolongs the inhibition of exocytosis, and suppresses leukocyte

  5. NSF independent fusion of Salmonella-containing late phagosomes with early endosomes.

  6. analysis of human NSF possible binding mode to GABARAP (show GABARAP Proteins) and GATE-16 (show GABARAPL2 Proteins)

  7. binding of NSF to GluR2 (show GRIA2 Proteins)-containing AMPARs in stabilizing these receptors in the synaptic membrane and impeding their regulated endocytosis.

  8. role of interaction with GluR2 (show GRIA2 Proteins) in regulation of AMPA (show GRIA3 Proteins) receptors by brain-derived neurotrophic factor (show BDNF Proteins)

  9. Nitric oxide regulates exocytosis by S-nitrosylation of NSF.

  10. Expressing a biochemically defined NSF mutant that lacks ATPase activity results in a dramatic inhibition of stimulated mast cell exocytosis.

Cow (Bovine) N-Ethylmaleimide-Sensitive Factor (NSF) interaction partners

  1. Report depletion of the ATPase NSF from Golgi membranes with hypo-S-nitrosylation of vasorelevant proteins in endothelial cells exposed to monocrotaline pyrrole.

Zebrafish N-Ethylmaleimide-Sensitive Factor (NSF) interaction partners

  1. Molecular analysis of ndrg4 (show NDRG4 Proteins) mutants shows that expression of snap25 (show SNAP25 Proteins) and nsf are sharply decreased, revealing a role of ndrg4 (show NDRG4 Proteins) in controlling vesicle exocytosis. This uncovers a previously unknown function of ndrg4 (show NDRG4 Proteins) in regulating vesicle docking and nodes of Ranvier organization, at least through its ability to finely tune the expression of the t-SNARE (show NAPA Proteins)/NSF machinery.

  2. results establish a role for Nsf in the maintenance of synaptic contacts between hair cells and afferent neurons, mediated in part via the secretion of trophic signaling factors

  3. Nsf is essential in the formation of the nodes of Ranvier in the vertebrate nervous system.

  4. Activation of PKCgamma is necessary for the activity-dependent trafficking of AMPARs in embryonic zebrafish and is NMDA and SNARE-dependent and requires AMPARs to associate with both NSF and PICK1.

  5. This study analyses of nsf mutant zebrafish reveal an unexpected role for NSF in hypothalamic development, with mutant 5 days post-fertilization larvae exhibiting a stage-dependent loss of neuroendocrine transcripts.

NSF Protein Profile

Protein Summary

Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seem to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity).

Gene names and symbols associated with NSF

  • N-ethylmaleimide-sensitive factor (NSF)
  • N-ethylmaleimide sensitive factor, vesicle fusing ATPase (NSF)
  • N-ethylmaleimide sensitive factor (nsf)
  • N-ethylmaleimide-sensitive factor (BBOV_II007200)
  • N-ethylmaleimide-sensitive fusion protein, putative (TGME49_318510)
  • N-ethylmaleimide sensitive factor L homeolog (nsf.L)
  • vesicle-fusing ATPase (LOC100180685)
  • N-ethylmaleimide-sensitive factor-like (LOC100519170)
  • vesicle-fusing ATPase (LOC9310886)
  • AAA-type ATPase family protein (NSF)
  • N-ethylmaleimide sensitive fusion protein (Nsf)
  • N-ethylmaleimide sensitive factor, vesicle fusing ATPase (Nsf)
  • N-ethylmaleimide-sensitive factor a (nsfa)
  • 18.m06598 protein
  • AI316878 protein
  • AU020090 protein
  • AU067812 protein
  • N-ethylmaleimide sensitive factor protein
  • nsf protein
  • si:bz18k17.1 protein
  • SKD2 protein
  • T1J1.4 protein
  • T1J1_4 protein
  • wu:fj33g11 protein

Protein level used designations for NSF

vesicle-fusing ATPase , N-ethylmaleimide-sensitive factor , N-ethylmaleimide-sensitive fusion protein , NEM-sensitive fusion protein , vesicular-fusion protein NSF , vesicle-fusing ATPase-like , N-ethylmaleimide sensitive factor , suppressor of K(+) transport growth defect 2 , N-ethylmaleimide sensitive fusion protein , N-ethylmaleimide-sensitive factor-like protein

373397 Strongylocentrotus purpuratus
454819 Pan troglodytes
780249 Xenopus (Silurana) tropicalis
5478472 Babesia bovis T2Bo
7901210 Toxoplasma gondii ME49
100024726 Monodelphis domestica
100049722 Xenopus laevis
100063690 Equus caballus
100174078 Pongo abelii
100180685 Ciona intestinalis
100472215 Ailuropoda melanoleuca
100519170 Sus scrofa
9310886 Arabidopsis lyrata subsp. lyrata
779070 Xenopus laevis
825830 Arabidopsis thaliana
18195 Mus musculus
60355 Rattus norvegicus
419972 Gallus gallus
4905 Homo sapiens
504457 Bos taurus
490921 Canis lupus familiaris
100624659 Sus scrofa
101120344 Ovis aries
368483 Danio rerio
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