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N-Glycanase 1 Proteins (NGLY1)

NGLY1 encodes an enzyme that catalyzes hydrolysis of an N(4)-(acetyl-beta-D-glucosaminyl) asparagine residue to N-acetyl-beta-D-glucosaminylamine and a peptide containing an aspartate residue. Additionally we are shipping N-Glycanase 1 Antibodies (7) and N-Glycanase 1 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NGLY1 55768 Q96IV0
NGLY1 59007 Q9JI78
NGLY1 361014 Q5XI55
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Top N-Glycanase 1 Proteins at antibodies-online.com

Showing 9 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Schizosaccharomyces pombe His tag   1 mg Log in to see 56 to 66 Days
$2,898.50
Details
Yeast Candida albicans His tag   1 mg Log in to see 56 to 66 Days
$3,091.00
Details
Yeast Emericella nidulans His tag   1 mg Log in to see 56 to 66 Days
$3,234.00
Details
Yeast Aspergillus oryzae His tag   1 mg Log in to see 56 to 66 Days
$3,285.33
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,884.83
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

NGLY1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for N-Glycanase 1 (NGLY1) Interaction Partners

Human N-Glycanase 1 (NGLY1) interaction partners

  1. The patients with NGLY1 deficiency show developmental delay, seizures, peripheral neuropathy, abnormal liver function and alacrima.

  2. This review summarizes the research history of cytoplasmic PNGase.

  3. NGLY1 mutation causes neuromotor impairment, intellectual disability, and neuropathy

  4. Data indicate that N-glycanase 1 (NGLY1) deficiency is a novel autosomal recessive disorder of the endoplasmic reticulum-associated degradation pathway associated with neurological dysfunction, abnormal tear production, and liver disease.

  5. PNGase-PUB serves not only as p97 (show EIF4G2 Proteins)-binding module but also as a possible activator of HR23 in endoplasmic reticulum-associated degradation mechanisms.

  6. As the generation of the bulk of fOS is unaffected by co-down regulation of Ngly1p and Engase1p, alternative quantitatively important mechanisms must underlie the liberation of these fOS from either LLO or glycoproteins during protein N-glycosylation.

  7. the PUB domain functions as a p97 (show EIF4G2 Proteins) binding module in human peptide N-glycanase

  8. generation of an HLA-A*0201-associated epitope from tyrosinase (show TYR Proteins) with deamidation of Asn to Asp (show ASIP Proteins) is dependent on glycosylation in the endoplasmic reticulum (ER), and subsequent deglycosylation by peptide-N-glycanase in the cytosol

  9. Describes the function of Yeast PNG1 and identifies similar proteins in mouse, human, D. melanogaster, C. elegans, and S. pombe.

Mouse (Murine) N-Glycanase 1 (NGLY1) interaction partners

  1. study underscores the functional importance of Ngly1 in the ERAD process and provides a potential mechanism underlying the phenotypic consequences of a newly emerging genetic disorder caused by mutation of the human NGLY1 gene

  2. Data show that both the yeast PNG1 enzyme and its mammalian homolog display N-glycanase activity towards intact glycoproteins.

  3. results suggested two possible pathways for the interaction between mPNGase and the proteasome; in one, mHR23B (show RAD23B Proteins) mediates the interaction between mPNGase and the proteasome; in an alternative pathway, mPNGase directly binds to the proteasome subunit, mS4

  4. The crystal structure of the mouse peptide N-glycanase catalytic core in complex with the xeroderma pigmentosum group C binding domain from HR23B (show RAD23B Proteins) is described; the results suggest a co-evolution of ER-associated degradation and DNA repair pathways.

  5. cytoplasmic protein (show BLZF1 Proteins) mouse p97 (show EIF4G2 Proteins)(mp97) participates in the formation of a ternary complex containing mouse autocrine motility factor receptor (show AMFR Proteins) (mAMFR), mp97, and peptide N-glycanase

  6. enhances the activity of the mouse PNGase core domain, presumably by increasing the affinity of mouse PNGase for the glycan chains of misfolded glycoproteins

  7. crystal structure of the N-terminal domain of PNGase in complex with this motif provides detailed insight into the interaction between p97 (show EIF4G2 Proteins) and its substrate-processing cofactors

Arabidopsis thaliana N-Glycanase 1 (NGLY1) interaction partners

  1. The plant PNGase facilitates ERAD through its deglycosylation activity, while the catalytic mutant of AtPNG1 impair glycoprotein ERAD by binding to N-glycans on the ERAD substrates.

  2. the AtPng1p gene product acts as a transglutaminase; the first reported plant protein, characterized at molecular level showing TGase (show TGM1 Proteins) activity. [AtPng1p]

  3. AtPng1p, the first plant transglutaminase sequenced shows undetectable sequence homology to the animal enzymes, except for the catalytic triad. It is, however, endowed with a calcium-dependent activity that allowed us to build a three-dimensional model.

Caenorhabditis elegans (C. elegans) N-Glycanase 1 (NGLY1) interaction partners

  1. Caenorhabditis elegans PNG-1 exhibits dual enzyme functions, not only as PNGase but also as an oxidoreductase (show HSD17B6 Proteins) (thioredoxin).

  2. Authors show a developmental role for a PNGase and Rad-23 in the regulation of neuronal branching during organ innervation.

N-Glycanase 1 (NGLY1) Protein Profile

Protein Summary

This gene encodes an enzyme that catalyzes hydrolysis of an N(4)-(acetyl-beta-D-glucosaminyl) asparagine residue to N-acetyl-beta-D-glucosaminylamine and a peptide containing an aspartate residue. The encoded enzyme may play a role in the proteasome-mediated degradation of misfolded glycoproteins. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with N-Glycanase 1 Proteins (NGLY1)

  • N-glycanase 1 (NGLY1)
  • N-glycanase 1 (ngly1)
  • N-glycanase 1 (LOC100228315)
  • N-glycanase 1 (LOC100351931)
  • N-glycanase 1 (Ngly1)
  • peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (PNG1)
  • Protein PNG-1 (png-1)
  • similar to S. cerevisiae PNG1 (YPL096W) peptide:N-glycanase de-N-glycosylation enzyme (PNG1)
  • 1110002C09Rik protein
  • AtPNG1 protein
  • CDG1V protein
  • im:6895151 protein
  • K6M13.12 protein
  • K6M13_12 protein
  • peptide-N-glycanase 1 protein
  • Png1 protein
  • PNGase protein
  • zgc:110561 protein

Protein level used designations for N-Glycanase 1 Proteins (NGLY1)

peptide-N(4)-(N-acetyl-beta-glucosaminyl) asparagine amidase , N-glycanase 1 , Peptide-N4-N-acetyl-beta-glucosaminylasparagine amidase , hPNGase , peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase , peptide:N-glycanase , mPNGase , peptide N-glycanase homolog , PNGase , potential de-N-glycosylation enzyme

GENE ID SPECIES
460233 Pan troglodytes
700842 Macaca mulatta
733299 Xenopus laevis
100075786 Ornithorhynchus anatinus
100228315 Taeniopygia guttata
100351931 Oryctolagus cuniculus
100380716 Salmo salar
55768 Homo sapiens
59007 Mus musculus
361014 Rattus norvegicus
420655 Gallus gallus
553627 Danio rerio
835019 Arabidopsis thaliana
173028 Caenorhabditis elegans
3646591 Candida albicans SC5314
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