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NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. Additionally we are shipping NMI Antibodies (47) and NMI Proteins (11) and many more products for this protein.
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We propose a novel genome-wide mechanism where myosin synergizes with Pol II-associated actin to link the polymerase machinery with permissive chromatin for transcription activation.
Our observations demonstrate specific changes in the expression of myosin IC (show MYO1C ELISA Kits) isoform A that are concurrent with the occurrence of prostate cancer in the TRAMP (show DPT ELISA Kits) mouse prostate cancer model that closely mimics clinical prostate cancer
Ca(2+) binding to calmodulin induces major conformational changes in both IQ motifs and the post-IQ domain and increases flexibility of the myosin-1c tail.
The v-Crk-myosin-1c interaction, which modulates membrane dynamics by regulating Rac1 activity, is crucial for cell adhesion and spreading.
These findings suggest that Nmi is a negative regulator of the virus-triggered induction of type I IFNs that targets IRF7 (show IRF7 ELISA Kits)
Mouse nuclear myosin I knock-out shows interchangeability and redundancy of myosin isoforms in the cell nucleus.
Myo1c (show MYO1C ELISA Kits) functions as a slow transporter rather than a tension-sensitive anchor.
the novel specific NLS (show ALDH1A2 ELISA Kits) brings to the cell nucleus not only the "nuclear" isoform of myosin I (show MYO1A ELISA Kits) (NM1 (show MYO1C ELISA Kits) protein) but also its "cytoplasmic" isoform (Myo1c (show MYO1C ELISA Kits) protein)
The data suggest that Myosin 1c is involved in the cytoskeleton dynamics and membrane protein anchoring or sorting in B lymphocytes
A hearing loss-associated myo1c mutation (R156W) decreases the myosin duty ratio and force sensitivity
N-myc and STAT interactor sensitizes breast cancer cells to cisplatin treatment through DRAM1 (show DRAM1 ELISA Kits) dependent autophagy.
Results show that aberrant miR (show MLXIP ELISA Kits)-29 expression may account for reduced NMI (show MYO1C ELISA Kits) expression in breast tumors and mesenchymal phenotype of cancer cells that promotes invasive growth.
The results showed that SARS (show SARS ELISA Kits) coronavirus protein 6 can promote the ubiquitin-dependent proteosomal degradation of Nmi (show MYO1C ELISA Kits).
overexpression or depletion of NMI (show MYO1C ELISA Kits) revealed its regulation on G1/S progression and cell proliferation (both in vitro and in vivo), and this effect was partially dependent on STAT1 (show STAT1 ELISA Kits), which interacted with and was regulated by NMI (show MYO1C ELISA Kits).
Trim21 (show TRIM21 ELISA Kits) regulates Nmi (show MYO1C ELISA Kits)-IFI35 (show IFI35 ELISA Kits) complex-mediated inhibition of innate antiviral response
Its potential function in transcriptional activation of NMI (show MYO1C ELISA Kits).
identified NMI (show MYO1C ELISA Kits) induction as a novel negative feedback mechanism that decreases IRE1alpha (show ERN1 ELISA Kits)-dependent activation of JNK (show MAPK8 ELISA Kits) and apoptosis in cytokine-exposed beta cells
Thus our work reveals a novel NMI-mediated, transcription-independent ARF induction pathway in response to cellular stresses.
Dissociation of the IFN-induced protein NMI (show MYO1C ELISA Kits) from IFP35 (show IFI35 ELISA Kits) is a newly defined specific cytoplasmic event occurring during apoptosis.
complex with BRCA1 and c-Myc (show MYC ELISA Kits) inhibits c-Myc (show MYC ELISA Kits)-induced human telomerase reverse transcriptase (show TERT ELISA Kits) gene promoter activity in breast cancer
NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias.
N-myc (and STAT) interactor
, N-myc and STAT interactor
, myosin I beta
, nuclear myosin I beta
, unconventional myosin-Ic
, N-myc interactor
, N-mcy (and STAT) interactor