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NQO1 is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. Additionally we are shipping NQO1 Kits (29) and NQO1 Proteins (16) and many more products for this protein.
Showing 10 out of 203 products:
Dog (Canine) Monoclonal NQO1 Primary Antibody for FACS, ICC - ABIN152344
Siegel, Franklin, Ross: Immunohistochemical detection of NAD(P)H:quinone oxidoreductase in human lung and lung tumors. in Clinical cancer research : an official journal of the American Association for Cancer Research 1998
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Human Polyclonal NQO1 Primary Antibody for ELISA, WB - ABIN184714
Asher, Lotem, Kama, Sachs, Shaul: NQO1 stabilizes p53 through a distinct pathway. in Proceedings of the National Academy of Sciences of the United States of America 2002
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Dog (Canine) Polyclonal NQO1 Primary Antibody for ELISA, WB - ABIN249473
Singh, Zahid, Saeed, Gaikwad, Meza, Cavalieri, Rogan, Chakravarti: NAD(P)H:quinone oxidoreductase 1 Arg139Trp and Pro187Ser polymorphisms imbalance estrogen metabolism towards DNA adduct formation in human mammary epithelial cells. in The Journal of steroid biochemistry and molecular biology 2009
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Human Polyclonal NQO1 Primary Antibody for IF (p), IHC (p) - ABIN678428
Wang, Peng, Wei, Wei, Wang, Ma, Yao, Fu, Zu: Geraniin exerts cytoprotective effect against cellular oxidative stress by upregulation of Nrf2-mediated antioxidant enzyme expression via PI3K/AKT and ERK1/2 pathway. in Biochimica et biophysica acta 2015
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Human Monoclonal NQO1 Primary Antibody for FACS, ELISA - ABIN969320
Kansanen, Jyrkkänen, Volger, Leinonen, Kivelä, Häkkinen, Woodcock, Schopfer, Horrevoets, Ylä-Herttuala, Freeman, Levonen: Nrf2-dependent and -independent responses to nitro-fatty acids in human endothelial cells: identification of heat shock response as the major pathway activated by nitro-oleic acid. in The Journal of biological chemistry 2009
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Human Monoclonal NQO1 Primary Antibody for FACS, IHC - ABIN969319
Douglas, Lim, Porter, West, Pink, Ge, Wylie, Tibbits, Biggs, Curtis, Palombella, Adams, Fritz, Normant: The antiproliferative activity of the heat shock protein 90 inhibitor IPI-504 is not dependent on NAD(P)H:quinone oxidoreductase 1 activity in vivo. in Molecular cancer therapeutics 2009
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Human Polyclonal NQO1 Primary Antibody for WB - ABIN1686087
La Sala, Pujadas, De Nigris, Canivell, Novials, Genovese, Ceriello: Oscillating glucose and constant high glucose induce endoglin expression in endothelial cells: the role of oxidative stress. in Acta diabetologica 2014
Mouse (Murine) Monoclonal NQO1 Primary Antibody for ICC, FACS - ABIN1042634
Siegel, Ross: Immunodetection of NAD(P)H:quinone oxidoreductase 1 (NQO1) in human tissues. in Free radical biology & medicine 2001
Coptisine exerted its antioxidant activity against AAPH-induced toxicity involving in activating Akt (show AKT1 Antibodies) and JNK (show MAPK8 Antibodies)/Nrf2 (show NFE2L2 Antibodies)/NQO1 pathway.
This study suggests that HNC (show MMP8 Antibodies) samples should be screened for NQO1 expression to identify patients that will likely benefit from combined therapy with beta-lap and IR.
The results indicate that NQO1*2 genotype may increase susceptibility to DN in north Indian subjects with T2DM.
Thus, our findings indicated that NQO1 could stabilize Herp (show HERPUD1 Antibodies) protein expression via indirect regulation of synoviolin.
NQO1 and GCLC (show GCLC Antibodies) were both functionally sufficient to autonomously confer a tamoxifen-resistant metabolic phenotype, characterized by i) increased mitochondrial biogenesis, ii) increased ATP production and iii) reduced glutathione levels.
NQO1 induces hepatocellular carcinoma cell apoptosis and proliferation inhibition through the AMPK (show PRKAA1 Antibodies)/PGC-1alpha (show PPARGC1A Antibodies) pathway.
the expression of NRF2 (show GABPA Antibodies), KEAP1 (show KEAP1 Antibodies), NQO-1 and HO-1 (show HMOX1 Antibodies) are increased significantly in advanced laryngeal squamous cell carcinoma, compared with the adjacent normal mucosa. Remarkable relevance exists between high expression of KEAP1 (show KEAP1 Antibodies), NQO-1, HO-1 (show HMOX1 Antibodies) and nuclear NRF2 (show GABPA Antibodies). their expression levels were independent of age, tumor stage (clinical stage III and IV), tumor size and lymph node metastasis.
(i) melatonin counteracted UVR-induced alterations in the ATP synthesis and reduced free radical formation; (ii) melatonin induced the translocation of Nrf2 (show GABPA Antibodies) transcription factor from the cytosol into the nucleus resulting in, (iii) melatonin enhanced gene expression of phase-2 antioxidative enzymes including gamma-glutamylcysteine synthetase (show GCLC Antibodies) (gamma-GCS (show GCLC Antibodies)), heme oxygenase-1 (HO-1 (show HMOX1 Antibodies)), and NADPH: quinone dehydrogenase-1 (NQO1...
Coptisine exerted its antioxidant activity against AAPH-induced toxicity involving in activating Akt (show AKT1 Antibodies) and JNK (show MAPK8 Antibodies)/Nrf2 (show GABPA Antibodies)/NQO1 pathway.
significant structural and functional changes incurred by NQO1 antioxidant protein (show PRDX3 Antibodies) as a result of alteration in its nucleotide, are reported.
Study provides a comprehensive picture of the structural and dynamic consequences of NQO1 polymorphisms, linking changes in protein dynamics with impaired NQO1 function and FAD (show BRCA2 Antibodies) binding, particularly for p.P187S, leading to increased cancer susceptibility.
NQO1 and autophagy participate in a protective role in cisplatin injury.
A significant increase was found in Nrf2 (show NFE2L2 Antibodies)-ARE activity after partial hepatectomy (PHx). The signal maximum was recorded on the third day after PHx. Significantly more hepatocytes were positive for Nrf2 (show NFE2L2 Antibodies) and HO-1 (show HMOX1 Antibodies) on the third postoperative day compared with baseline levels. The mRNA expression of HO-1 (show HMOX1 Antibodies) and NQO1 were significantly increased on day 3.
Miroestrol restored hepatic NQO1 expression in beta-naphthoflavone-treated mice.
previous and present results collectively show that NQO1 is involved in the formation of tight junctions in the small intestine, and that defects in NQO1 enhance C. difficile toxin A-induced acute inflammatory responses, presumably via the loss of epithelial cell tight junctions
NQO1 plays a critical role in protection against energy depletion in acetaminophen-induced liver injury, and is associated with improvement of mitochondrial dysfunction
The present results demonstrate that exacerbated cisplatin-induced nephrotoxicity under the NQO1-knockout condition was accompanied by the reduced expression of MRN complex proteins, ATM (show ATM Antibodies), PARP1 (show PARP1 Antibodies), and Sirt1 (show SIRT1 Antibodies).
Taken together, these data suggest that EEEC attenuates oxidative stress by activating Nrf2 (show NFE2L2 Antibodies)-mediated HO-1 (show HMOX1 Antibodies) and inducing NQO-1 via the activation of MAPK (show MAPK1 Antibodies) signaling pathways.
We defined the basal and butylated hydroxyanisole induced expression patterns of Nqo1, AKR1B8, and Ho-1 (show HMOX1 Antibodies) in the liver and small intestine of C57BL/6 mice.
The colons of NQO1-KO mice also showed high levels of reactive oxygen species (ROS (show ROS1 Antibodies)) and histone deacetylase (HDAC (show HDAC1 Antibodies)) activity, which are known to affect transcriptional regulation.
the induction of cellular NAD(+) levels using beta-lapachone (beta-Lap), whose intracellular target is NQO1, prevents the toxic effects of cisplatin through the regulation of PARP-1 (show PARP1 Antibodies) and SIRT1 (show SIRT1 Antibodies) activity.
The obtained data convincingly showed that porcine NADPH-d cells may produce nitric oxide.
Immunoreactivity of eNOS (show NOS3 Antibodies) was similar to NADPH-d staining. Clear iNOS (show NOS2 Antibodies) immunoreactivity was detected in the luminal epithelium, endometrial stroma and individual endometrial glands.
NQO1 expression was increased in the ruminal papillae of more efficient low residual feed intake (RFI (show RNF34 Antibodies)) animals compared to the high RFI (show RNF34 Antibodies) animals
This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
NAD(P)H dehydrogenase [quinone] 1
, NAD(P)H menadione oxidoreductase 1, dioxin-inducible
, NAD(P)H dehydrogenase, quinone 1
, NAD(P)H:quinone oxidoreductase 1
, menadione reductase
, phylloquinone reductase
, quinone reductase 1
, nad(p)h dehydrogenase (quinone) 1
, NAD(P)H:Quinone acceptor oxidoreductase type 1
, NAD(P)H:menadione oxidoreductase 1
, NAD(P)H:quinone oxireductase
, diaphorase (NADH/NADPH) (cytochrome b-5 reductase)
, dioxin-inducible 1
, Diaphorase (NADH/NADPH)
, NAD(P)H:menadione oxidoreductase
, NAD(P)H dehydrogenase (quinone)
, NAD(P)H menadione oxidoreductase 1, dioxin inducible
, diaphorase 4 (NADH/NADPH)
, nicotinamide adenine dinucleotide phosphate diaphorase
, diaphorase 4
, NAD(P)H: quinone oxidoreductase 1