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NAD Dependent Malate Dehydrogenase Proteins (NAD-ME)

NAD-ME encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. Additionally we are shipping NAD Dependent Malate Dehydrogenase Antibodies (32) and NAD Dependent Malate Dehydrogenase Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NAD-ME 4200 P23368
Rat NAD-ME NAD-ME 307270  
NAD-ME 107029 Q99KE1
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Top NAD Dependent Malate Dehydrogenase Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag   100 μg Log in to see 9 to 11 Days
$499.40
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

NAD-ME Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

Mouse (Murine)

More Proteins for NAD Dependent Malate Dehydrogenase (NAD-ME) Interaction Partners

Human NAD Dependent Malate Dehydrogenase (NAD-ME) interaction partners

  1. Data indicate that malic enzyme 2 knockdown impacts phosphatidylinositol 3-kinases/proto-oncogene (show RAB1A Proteins) protein akt (show AKT1 Proteins) (PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins)) signaling.

  2. ME2 might be an important factor in melanoma progression and a novel biomarker of invasion.

  3. Three SNP alleles in BRD2 (show BRD2 Proteins), Cx-36 (show GJD2 Proteins), and ME2 and microdeletions in 15q13.3, 15q11.2, and 16p13.11 also contribute risk to juvenile myclonic epilepsy.

  4. p53 (show TP53 Proteins) represses the expression of the tricarboxylic-acid-cycle-associated malic enzymes ME1 (show ME1 Proteins) and ME2 in human and mouse cells

  5. Depletion of malic enzyme 2 induced erythroid differentiation in human erythroleukemia cells.

  6. An ME2-centered nine-SNP haplotype, when present homozygously, increases the risk for IGE (odds ratio 6.1; 95% confidence interval 2.9-12.7) compared with any other genotype

  7. Schizophrenic subjects are identified with mitochondrial genes involved in oxidative metabolism as showing consistently decreased expression, including ME2.

  8. Single nucleotide polymorphism in ME2 gene is associated with acute lymphoblastic leukemia.

  9. ME2 activity in Islets of Langerhans cells was measured by a spectrophotometric enzyme assay by utilizing the distinct kinetic properties.

Mouse (Murine) NAD Dependent Malate Dehydrogenase (NAD-ME) interaction partners

  1. Conditional expression of E2A (show TCF3 Proteins)-HLF (show HLF Proteins) induces B-cell precursor death and myeloproliferative-like disease in knock-in mice.

  2. Upregulation of E12/E47 by HBx ultimately and concomitant repression of E-cadherin (show CDH1 Proteins) expression led to epithelial-mesenchymal transition in human hepatocytes.

  3. Mechanistically, E47 (show TCF3 Proteins) repressed the expression of several astrocyte-specific genes in adult NSPCs.

  4. Tcf3 (show TCF7L1 Proteins) is upregulated in skin wounds and Tcf3 (show TCF7L1 Proteins) overexpression accelerates keratinocyte migration and skin wound healing.

  5. Loss and gain of function analyses combined with in vivo studies in syngeneic breast cancer models demonstrate the participation of LOXL2 (show LOXL3 Proteins) and E47 (show TCF3 Proteins) in tumor growth and their requirement for lung metastasis.

  6. Tcf3 (show TCF7L1 Proteins) has a role in repressing Wnt (show WNT2 Proteins)-beta-catenin (show CTNNB1 Proteins) signaling and maintaining neural stem cell population during neocortical development

  7. the role of Tcf3 (show TCF7L1 Proteins) in cell-fate decision is more complex than previously appreciated and is highly dependent on cellular context

  8. Id2 represses E2A (show TCF3 Proteins)-mediated activation of IL-10 (show IL10 Proteins) expression in T cells.

  9. transcription factor E2A binds to the UNG2 (show UNG Proteins) promoter and represses UNG2 (show UNG Proteins) expression.

  10. pre-BCR (show BCR Proteins) signaling downregulates several components of the recombination machinery, including RAG1 (show RAG1 Proteins), RAG2 (show RAG2 Proteins), and PAX5 (show PAX5 Proteins), through calmodulin (show Calm2 Proteins) inhibition of E2A (show TCF3 Proteins).

NAD Dependent Malate Dehydrogenase (NAD-ME) Protein Profile

Protein Summary

This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene.

Gene names and symbols associated with NAD-ME

  • malic enzyme 2, NAD(+)-dependent, mitochondrial (ME2)
  • malic enzyme 2, NAD(+)-dependent, mitochondrial (me2)
  • malic enzyme 2, NAD(+)-dependent, mitochondrial (Me2)
  • transcription factor 3 (Tcf3)
  • A1 protein
  • AA408400 protein
  • ALF2 protein
  • AW120568 protein
  • AW209082 protein
  • bHLHb21 protein
  • D030040L20Rik protein
  • E2A protein
  • E12 protein
  • E12/E47 protein
  • E47 protein
  • ME2 protein
  • NAD-ME protein
  • ODS1 protein
  • Pan1 protein
  • Pan2 protein
  • Tcfe2a protein
  • VDIR protein

Protein level used designations for NAD-ME

NAD-ME , NAD-dependent malic enzyme, mitochondrial , malate dehydrogenase , pyruvic-malic carboxylase , malic enzyme 2 , TCF-3 , immunoglobulin enhancer-binding factor E12/E47 , transcription factor A1 , transcription factor E2-alpha , transcription factor E2a

GENE ID SPECIES
4200 Homo sapiens
398584 Xenopus laevis
476198 Canis lupus familiaris
507817 Bos taurus
307270 Rattus norvegicus
107029 Mus musculus
21423 Mus musculus
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