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NADH Dehydrogenase (Ubiquinone) Fe-S Protein 2, 49kDa (NADH-Coenzyme Q Reductase) (NDUFS2) ELISA Kits

The protein encoded by NDUFS2 is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I). Additionally we are shipping NDUFS2 Antibodies (65) and NDUFS2 Proteins (10) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse NDUFS2 NDUFS2 226646 Q91WD5
Anti-Rat NDUFS2 NDUFS2 289218 Q641Y2
Anti-Human NDUFS2 NDUFS2 4720 O75306
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More ELISA Kits for NDUFS2 Interaction Partners

Mouse (Murine) NADH Dehydrogenase (Ubiquinone) Fe-S Protein 2, 49kDa (NADH-Coenzyme Q Reductase) (NDUFS2) interaction partners

  1. Ndufs2-null mice lose the hyperventilatory response to hypoxia, although they respond to hypercapnia. Ndufs2-deficient CB cells have normal functions and ATP content but are insensitive to changes in PO2.

Human NADH Dehydrogenase (Ubiquinone) Fe-S Protein 2, 49kDa (NADH-Coenzyme Q Reductase) (NDUFS2) interaction partners

  1. Results found nominal significant associations of 2 SNPs in the NDUFS1 (show NDUFS1 ELISA Kits) gene and 4 SNPs in the NDUFS2 gene with early onset schizophrenia (EOS (show IKZF4 ELISA Kits)), but none of these associations survived the Bonferroni correction.

  2. NDUFAF7 methylates arginine 85 in the NDUFS2 subunit of human complex I.

  3. study describes clinical, radiological, biochemical and molecular data of 6 patients with Leigh syndrome with novel mutations in NDUFV1 (show NDUFV1 ELISA Kits) and NDUFS2; 2 siblings were compound heterozygotes for an undescribed E104A mutation in NDUFS2

  4. The NDUFS2 mutation affects complex I enzymatic function.

  5. Our results confirm that NDUFS2 is a mutational hotspot in Caucasian children with isolated complex I deficiency and recommend the routine diagnostic investigation of this gene in patients with Leigh or Leigh-like phenotypes.

Cow (Bovine) NADH Dehydrogenase (Ubiquinone) Fe-S Protein 2, 49kDa (NADH-Coenzyme Q Reductase) (NDUFS2) interaction partners

  1. Data suggest that the active site domain of NDUFS2 (a 49 kDa subunit of mitochondrial complex I) in bovine heart mitochondria exhibits more than one access path by which ligands/chemicals can reach reactive residues.

NDUFS2 Antigen Profile

Antigen Summary

The protein encoded by this gene is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I). Mammalian mitochondrial complex I is composed of at least 43 different subunits, 7 of which are encoded by the mitochondrial genome, and the rest are the products of nuclear genes. The iron-sulfur protein fraction of complex I is made up of 7 subunits, including this gene product. Complex I catalyzes the NADH oxidation with concomitant ubiquinone reduction and proton ejection out of the mitochondria. Mutations in this gene are associated with mitochondrial complex I deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with NDUFS2

  • NADH dehydrogenase (ubiquinone) Fe-S protein 2 (Ndufs2) antibody
  • NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) (NDUFS2) antibody
  • AL033311 antibody
  • CI-49 antibody

Protein level used designations for NDUFS2

CI-49kD , NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial , NADH-coenzyme Q reductase , NADH-ubiquinone oxidoreductase 49 kDa subunit , complex I-49kD , NADH-ubiquinone oxidoreductase NDUFS2 subunit , complex 1, mitochondrial respiratory chain, 49-KD subunit , complex I 49kDa subunit , mitochondrial complex I subunit NDUFS2

GENE ID SPECIES
226646 Mus musculus
289218 Rattus norvegicus
4720 Homo sapiens
478981 Canis lupus familiaris
100156075 Sus scrofa
327697 Bos taurus
747334 Pan troglodytes
100857596 Gallus gallus
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