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anti-NADH Dehydrogenase (Ubiquinone) Fe-S Protein 4, 18kDa (NADH-Coenzyme Q Reductase) (NDUFS4) Antibodies

NDUFS4 encodes an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), or NADH:ubiquinone oxidoreductase, the first multi-subunit enzyme complex of the mitochondrial respiratory chain. Additionally we are shipping NADH Dehydrogenase (Ubiquinone) Fe-S Protein 4, 18kDa (NADH-Coenzyme Q Reductase) Proteins (12) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
NDUFS4 17993 Q9CXZ1
NDUFS4 499529 Q5XIF3
NDUFS4 4724 O43181
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Top anti-NADH Dehydrogenase (Ubiquinone) Fe-S Protein 4, 18kDa (NADH-Coenzyme Q Reductase) Antibodies at antibodies-online.com

Showing 10 out of 58 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of NDUFS4 Antibody (C-term) (ABIN390919) in HL-60 cell line lysates (35 µg/lane). NDUFS4 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human kidney carcinoma reacted with NDUFS4 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Formalin-fixed and paraffin-embedded human kidney carcinoma reacted with NDUFS4 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Western blot analysis of NDUFS4 Antibody (C-term) in HL-60 cell line lysates (35ug/lane). NDUFS4 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated WB Western blot analysis of NDUFS4 over-expressed 293 cell line, cotransfected with NDUFS4 Validated Chimera RNAi used as specificity and loading control. Western Blot analysis of NDUFS4 expression in transfected 293T cell line by NDUFS4 monoclonal antibody (M01), clone 1A1. Lane 1: NDUFS4 transfected lysate(20.1 KDa). Lane 2: Non-transfected lysate. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB WB Image Sample(30μg whole cell lysate) A: 293T 12% SDS PAGE antibody diluted at 1:1000 ICC/IF Image Immunofluorescence analysis of methanol-fixed HeLa, using NDUFS4, antibody at 1:100 dilution. 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated ICC, IHC (p), WB   100 μL Log in to see 8 to 10 Days
$507.83
Details
Human Mouse Un-conjugated ELISA, WB NDUFS4 monoclonal antibody (M01A), clone 1A1 Western Blot analysis of NDUFS4 expression in A-431 . Western Blot analysis of NDUFS4 expression in transfected 293T cell line by NDUFS4 monoclonal antibody (M01A), clone 1A1.Lane 1: NDUFS4 transfected lysate(20.1 KDa).Lane 2: Non-transfected lysate. 200 μL Log in to see 9 Days
$430.00
Details
Human Mouse Un-conjugated IHC (p), ELISA, WB 100 μg Log in to see 8 to 10 Days
$537.17
Details
Human Mouse Un-conjugated WB Western Blot analysis of NDUFS4 expression in transfected 293T cell line by NDUFS4 MaxPab polyclonal antibody.Lane 1: NDUFS4 transfected lysate(19.25 KDa).Lane 2: Non-transfected lysate. 50 μL Log in to see 9 Days
$430.00
Details
Human Mouse Un-conjugated IHC (p), RNAi, ELISA, WB Immunoperoxidase of monoclonal antibody to NDUFS4 on formalin-fixed paraffin-embedded human colon. [antibody concentration 1 ug/ml] NDUFS4 monoclonal antibody (M01), clone 1A1 Western Blot analysis of NDUFS4 expression in A-431 . 100 μg Log in to see 9 Days
$430.00
Details

NDUFS4 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-NADH Dehydrogenase (Ubiquinone) Fe-S Protein 4, 18kDa (NADH-Coenzyme Q Reductase) Antibodies

  1. Human Polyclonal NDUFS4 Primary Antibody for FACS, IHC (p) - ABIN390919 : Panelli, Petruzzella, Vitale, De Rasmo, Munnich, Rötig, Papa: The regulation of PTC containing transcripts of the human NDUFS4 gene of complex I of respiratory chain and the impact of pathological mutations. in Biochimie 2008 (PubMed)

More Antibodies against NADH Dehydrogenase (Ubiquinone) Fe-S Protein 4, 18kDa (NADH-Coenzyme Q Reductase) Interaction Partners

Mouse (Murine) NADH Dehydrogenase (Ubiquinone) Fe-S Protein 4, 18kDa (NADH-Coenzyme Q Reductase) (NDUFS4) interaction partners

  1. NDUFS4 deletion affected gene expression following neural differentiation and the potential of the cells to generate beating embryoid bodies.

  2. Using the Ndufs4 knockout (Ndufs4 KO) mouse, a model of Leigh syndrome, we demonstrate for the first time that protein succination is increased in the brainstem (BS), particularly in the vestibular nucleus.

  3. Locally insufficient respiration capacity of the nerve terminals may drive focal neurodegeneration in the Ndufs4 knockout mouse model of the Leigh syndrome.

  4. This study demonstrated that Genetic reduction of Ndufs4 function does not lead to loss of dopamine neurons in vivo.

  5. Mitochondrial complex I dysfunction in the retina, present in Ndufs4 KO mouse, triggers an innate immune and inflammatory response that results in loss of retinal ganglion cell function and death.

  6. Global Ndufs4 deletion causes systemic inflammation and osteopetrosis (show CSF1 Antibodies).

  7. Complex I deficiency due to selective loss of Ndufs4 in the mouse heart results in severe hypertrophic cardiomyopathy.

  8. deletion of Ndufs4 results in a significant loss of complex I-supported respiration in the heart, which is well tolerated with no major changes of cardiac function, energetics, and longevity of the mice under unstressed conditions.

  9. Oxidation of the reactive oxygen species sensor hydroethidium was increased and mitochondria were less branched and/or shorter in NDUFS4(-/-) fibroblasts.

  10. the NDUFS4 subunit is of key importance in CI stabilization

Human NADH Dehydrogenase (Ubiquinone) Fe-S Protein 4, 18kDa (NADH-Coenzyme Q Reductase) (NDUFS4) interaction partners

  1. The c.462delA deletion led to a complete lack of NDUFS4 peptide in isolated mitochondria, and this deficiency caused an inefficient mitochondrial complex I assembly and Leigh syndrome symptoms.

  2. Mutations in the NDUFS4 gene and its subunits are associated with the mitochondrial complex I deficiency. (Review)

  3. Elevated expression of CO I and ND4 (show MT-ND4 Antibodies) were associated with gastric tumorigenesis and tumor dedifferentiation

  4. Studies indicate that that the functional capacity of complex I depends on phosphorylation and import of subunit NDUFS4 protein.

  5. In fibroblast cultures, protein kinase A-mediated phosphorylation of the NDUFS4 subunit of complex I rescues the activity of the oxidatively damaged complex.

  6. case Report: A novel mutation in NDUFS4 causes Leigh syndrome in an Ashkenazi Jewish family.

  7. REVIEW: Phosphorylation of the NDUFS4 protein, overall respiratory activity, and mutations sassociated with deficiency of complex I.

  8. observations show the essential role of the 18-kDa subunit of respiratory complex I (NDUFS4) gene in the structure and function of complex I and give insight into pathogenic mechanism of NDUFS4 gene mutations in a severe defect of complex I

  9. A nonsense mutation leading to the abrogation of mRNA decay was found in NDUFS4 gene of a Leigh syndrome patient.

  10. mutations in the NDUFS1 (show NDUFS1 Antibodies) and NDUFS4 genes of complex I cause dysfunction in cellular oxidative metabolism

Cow (Bovine) NADH Dehydrogenase (Ubiquinone) Fe-S Protein 4, 18kDa (NADH-Coenzyme Q Reductase) (NDUFS4) interaction partners

  1. Two-dimensional gel electrophoresis, (32)P labelling and immunodetection show that "in vitro" PKA phosphorylates the serine in the C-terminus of the NDUFS4 subunit in isolated bovine complex I.

NADH Dehydrogenase (Ubiquinone) Fe-S Protein 4, 18kDa (NADH-Coenzyme Q Reductase) (NDUFS4) Antigen Profile

Protein Summary

This gene encodes an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), or NADH:ubiquinone oxidoreductase, the first multi-subunit enzyme complex of the mitochondrial respiratory chain. Complex I plays a vital role in cellular ATP production, the primary source of energy for many crucial processes in living cells. It removes electrons from NADH and passes them by a series of different protein-coupled redox centers to the electron acceptor ubiquinone. In well-coupled mitochondria, the electron flux leads to ATP generation via the building of a proton gradient across the inner membrane. Complex I is composed of at least 41 subunits, of which 7 are encoded by the mitochondrial genome and the remainder by nuclear genes.

Gene names and symbols associated with NDUFS4

  • NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) antibody
  • NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) (NDUFS4) antibody
  • 6720411N02Rik antibody
  • AQDQ antibody
  • C1-18k antibody
  • CI-18 antibody

Protein level used designations for NDUFS4

CI-18 kDa , CI-AQDQ , NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial , NADH-ubiquinone oxidoreductase 18 kDa subunit , complex I-18 kDa , complex I-AQDQ , NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) , NADH dehydrogenase (ubiquinone) iron-sulfur protein 4 , NADH-coenzyme Q reductase, 18-KD , complex I 18kDa subunit , mitochondrial respiratory chain complex I (18-KD subunit) , NADH-ubiquinone oxidoreductase 18 kDa subunit, mitochondrial

GENE ID SPECIES
17993 Mus musculus
499529 Rattus norvegicus
4724 Homo sapiens
374122 Gallus gallus
327680 Bos taurus
461878 Pan troglodytes
100172316 Pongo abelii
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