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The encoded protein is a subunit of the hydrophobic protein fraction of the NADH:ubiquinone oxidoreductase (complex 1), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane, and may be involved in regulating complex I activity or its assembly via assistance in redox processes. Additionally we are shipping NADH Dehydrogenase (Ubiquinone) 1 alpha Subcomplex, 2, 8kDa Antibodies (23) and many more products for this protein.
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The authors use green fluorescent-tagged complex I subunits to determine the kinetics of assembly. Tagged human NDUFA2 may incorporate into the holo-complex I enzyme as an assembly intermediate or as free monomers. The authors conclude that nuclear-encoded subunits incorporate into the holo-enzyme in a subunit-specific manner.
The authors determine the NMR structur (show TXN Proteins)e of the oxidized human NDUFA2 protein, also known as B8 (show TXN Proteins), and report that its structur (show TXN2 Proteins)e and redox potential is similar to that of thioredoxins. The highly conserved residues on the surface most likely form the protein-protein interaction site of this subunit with the large multimeric complex I.
differentially expressed in the brains of four mice strains; expression pattern follows ethanol preference of the strains [(NADH-ubiquinone oxidoreductase B8 subunit]
A novel mechanism of lipoteichoic acid (LTA (show LTA Proteins))-induced cytokine induction in human peripheral blood cells involves uptake of LTA (show LTA Proteins) and subsequent intracellular recognition driven by Toll (show TLR4 Proteins)-like receptor (TLR)2, TLR6 (show TLR6 Proteins), and CD14.
solution structure shows a thioredoxin (show TXN Proteins) fold with highest similarities to the human thioredoxin (show TXN Proteins) mutant C73S and thioredoxin 2 (show TXN2 Proteins) from Anabeana sp
The encoded protein is a subunit of the hydrophobic protein fraction of the NADH:ubiquinone oxidoreductase (complex 1), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane, and may be involved in regulating complex I activity or its assembly via assistance in redox processes. Mutations in this gene are associated with Leigh syndrome, an early-onset progressive neurodegenerative disorder. Alternative splicing results in multiple transcript variants.
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
, NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
, NADH-ubiquinone oxidoreductase B8 subunit
, OXPHOS complex I B8 subunit
, complex I-B8
, NADH-ubiquinone oxidoreductase subunit CI-B8
, complex I B8 subunit
, NADH-ubiquinone oxidoreductase complex