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The NADH-ubiquinone oxidoreductase complex (complex I) of the mitochondrial respiratory chain catalyzes the transfer of electrons from NADH to ubiquinone, and consists of at least 43 subunits. Additionally we are shipping NADH Dehydrogenase (Ubiquinone) Flavoprotein 2, 24kDa Proteins (11) and many more products for this protein.
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Human Polyclonal NDUFV2 Primary Antibody for IHC, IHC (p) - ABIN4338434
Choi, Batchu, Schubert, Castellani, Russell: A novel PGC-1α isoform in brain localizes to mitochondria and associates with PINK1 and VDAC. in Biochemical and biophysical research communications 2013
Show all 2 Pubmed References
The results of this study indicated that ndufv2 knockdown influences the actin cytoskeleton and tubulin (show TUBB Antibodies) stabilization in the leading process of migrating cortical neurons
The authors biochemically separate the NADH dehydrogenase (show NDUFA2 Antibodies) module from complex I of bovine heart into subunit I, II and III fractions. Subunit II fraction, also known as the NADH dehydrogenase (ubiquinone) flavoprotein 2 protein, has a molecular weight of 24 000 Da and contains an iron-sulfur center.
The authors use green fluorescent-tagged complex I subunits to determine the kinetics of assembly. Tagged human NDUFV2 can replace the endogenous protein in the holo-complex I protein and was also found in complex I subassemblies, suggesting that NDUFV2 may directly incorporate into the holo-enzyme and may also assemble into smaller complexes or in a monomer pool.
The authors provide an overview of the function and assembly of human complex I, also known as NADH dehydrogenase (show NDUFA2 Antibodies) (ubiquinone) 1 alpha subcomplex. They discuss its role in oxidative phosphorylation and the implications of complex I deficiency in disease.
haplotype T-C consisting of rs12457810 and rs12964485 in the 5'-upstream region of NDUFV2 may be a protective factor for the development of MDD in Han Chinese
We have identified NDUFV2 mutations in two families with Complex I deficiency, including a novel mutation.
There is no statistical significance between NDUFV2 gene promoter variants and susceptibility to schizophrenia in Han Chinese.
The mitochondrial targeting sequence of NDUFV2 is located at the N-terminus of the precursor protein. Impairment of mitochondrial localization of NDUFV2 as a mechanistic basis for early-onset hypertrophic cardiomyopathy and encephalopathy was established.
Three single nucleotide polymorphisms in the NDUFV2 gene, were studies in bipolar disorder pateints and controls.
Our findings suggest further studies addressing the role of NDUFV2 variation in Parkinson's disease may be warranted.
Sp1 (show PSG1 Antibodies) was abnormally expressed in schizophrenia and its mRNA alteration pattern paralleled that of NDUFV1 (show NDUFV1 Antibodies) and NDUFV2 in schizophrenic patients.
Polymorphisms in the promoter region of NDUFV2 are a genetic risk factor for bipolar disorder. The association of the haplotypes -602G> A and -3542G> A polymorphisms with bipolar disorder was seen both in Japanese case-control samples and NIMH trios.
NDUFV2 individual genotypes were not associated with schizophrenia, but the haplotype consisting of the two single nucleotide polymorphisms were significantly associated with schizophrenia.
genetic variants of NDUFV2 may increase risk for bipolar disorder.
Data show that during NADH-ubiquinone oxidoreductase (Complex (show NDUFA2 Antibodies) I) catalytic electron transfer from NADH to DBQ, the superoxide generation site was mostly shifted to the SQ.
Data suggest that Q(Nf) plays a role in a "direct" redox-driven proton pump, while Q(Ns) triggers an "indirect" conformation-driven proton pump in NADH-ubiquinone oxidoreductase (complex (show NDUFA2 Antibodies) I).
The catalytic function of NDH in the mediation of superoxide generation was investigated by EPR (show EREG Antibodies) spin-trapping.
The NADH-ubiquinone oxidoreductase complex (complex I) of the mitochondrial respiratory chain catalyzes the transfer of electrons from NADH to ubiquinone, and consists of at least 43 subunits. The complex is located in the inner mitochondrial membrane. This gene encodes the 24 kDa subunit of complex I, and is involved in electron transfer. Mutations in this gene are implicated in Parkinson's disease, bipolar disorder, schizophrenia, and have been found in one case of early onset hypertrophic cardiomyopathy and encephalopathy. A non-transcribed pseudogene of this locus is found on chromosome 19.
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
, NADH dehydrogenase ubiquinone flavoprotein 2
, NADH-ubiquinone oxidoreductase 24 kDa subunit
, NADH dehydrogenase [ubiquinone] flavoprotein 2,mitochondrial
, OXPHOS complex I 24 kDa subunit
, NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
, NADH dehydrogenase flavoprotein 2, 24kDa
, 24-kDa subunit of mitochondrial NADH dehydrogenase
, NADH dehydrogenase ubiquinone flavoprotein 2, mitochondrial
, NADH-ubiquinone oxidoreductase flavoprotein 2
, complex I 24kDa subunit
, complex I, mitochondrial respitory chain, 24 kD subunit
, nuclear-encoded mitochondrial NADH-ubiquinone reductase 24Kd subunit
, NADH dehydrogenase flavoprotein 2
, NADH dehydrogenase subunit II
, NADH-ubiquinone reductase 24 kDa mitochondrial