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NOX4 encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. Additionally we are shipping NADPH Oxidase 4 Antibodies (119) and NADPH Oxidase 4 Proteins (9) and many more products for this protein.
Showing 6 out of 16 products:
Human NOX4 ELISA Kit for Sandwich ELISA - ABIN417447
Vital, Castro, Ittmann: Oxidative stress promotes benign prostatic hyperplasia. in The Prostate 2016
Rat (Rattus) NOX4 ELISA Kit for Sandwich ELISA - ABIN431602
El-Naga: Apocynin protects against ethanol-induced gastric ulcer in rats by attenuating the upregulation of NADPH oxidases 1 and 4. in Chemico-biological interactions 2015
Data suggest that NOX4 and mitochondrial oxidative stress are mediators of cardiovascular disease in aging under hyperlipidemic conditions.
Downregulation of smooth muscle Nox4 inhibits neointimal hyperplasia by suppressing TSP1 (show THBS1 ELISA Kits).
High expression of NOX4 is associated with metastasis in prostate cancer.
The angiogenic effect of TRAIL on human microvascular endothelial cell-1 cells i (show NOS3 ELISA Kits)s downstream of fibroblast growth factor-2, involving NOX4 and nitric oxide signaling.
A deep understanding of Nox4 structure/function and mechanisms of regulation could lead both to the identification of new therapeutic targets and to the development of innovative strategies for appropriate osteoarthritis treatment. [review]
Expression of NOX4/p22(phox (show CYBA ELISA Kits)) as well as ROS (show ROS1 ELISA Kits) production is enhanced by IL-1beta (show IL1B ELISA Kits). On the other hand, the use of NOX4 inhibitors decreased IL-1beta (show IL1B ELISA Kits)-induced collagenase synthesis by chondrocytes.
Nox4 is a positive transcriptional regulator of cystathionine-gamma-lyase (show CTH ELISA Kits) in endothelial cells.
An endogenous NOX4 forms macromolecular complexes with calnexin (show CANX ELISA Kits), which are needed for the proper maturation, processing, and function of NOX4 in the endoplasmic reticulum.
IFNgamma induces oxidative stress, DNA damage and tumor cell senescence via TGFbeta/SMAD signaling-dependent induction of Nox4 and suppression of ANT2
Nox4 knockout (Nox4(-/-)) murine hematopoietic progenitor cells were refractory to FLT3ITD-mediated transformation in vitro
Peroxide derived from superoxide generated by Nox4 appears to maintain a basal relaxation in bovine pulmonary arteries under normoxic conditions, which is removed under hypoxia leading to hypoxic pulmonary vasoconstriction.
proteasome inhibition completely prevented endoplasmic reticulum stress-induced increase in NADPH oxidase (show NOX1 ELISA Kits) activity, as well as increases in Nox4 isoform and protein disulfide isomerase (show P4HB ELISA Kits) mRNA expression
the reduction of ROS (show ROS1 ELISA Kits) generation and NOX4 expression by EA preconditioning might be involved in BBB (show ALMS1 ELISA Kits) recovery. Therefore, EA may serve as a potential preventive strategy for patients at high risk of ischemic stroke.
Deleterious effect of Nox4 expression in podocytes by promoting podocytopathy in association with albuminuria and extracellular matrix accumulation in experimental diabetes, emphasizes the role of NOX4 as a target for new renoprotective agents.
Downregulation of smooth muscle Nox4 inhibits neointimal hyperplasia by suppressing TSP1 (show GZMA ELISA Kits).
TRAIL can promote angiogenesis following hindlimb ischemia in vivo via NOX4/eNOS (show NOS3 ELISA Kits)/nitric oxide signaling.
NOX4 may thus associate with mitochondrial complex I proteins, but in cardiac and renal mitochondria under basal conditions, expression is beyond our detection limits.
These results indicate that Ang-II (show AGT ELISA Kits) induces cardiac fibroblast proliferation and migration in part via Nox4/ROS (show ROS1 ELISA Kits)-dependent IL-18 (show IL18 ELISA Kits) induction and MMP9 (show MMP9 ELISA Kits) activation, and may involve AT1 (show SLC33A1 ELISA Kits)/Nox4 physical association.
H2O2-forming NOX4, unlike the superoxide-forming NOX1 (show NOX1 ELISA Kits), can act as a negative modulator of inflammation and remodeling and convey atheroprotection.
activated PKCzeta (show PRKCZ ELISA Kits) phosphorylated p65 (show NFkBP65 ELISA Kits) rel, which led to increased Nox4 synthesis
MRTF down-regulation/inhibition suppresses TGFbeta (show TGFB1 ELISA Kits)/contact disruption-provoked Nox4 protein and mRNA expression, Nox4 promoter activation, and reactive oxygen species production.
Nox4 NADPH oxidase (show NOX1 ELISA Kits) mediates oxidative stress and apoptosis caused by TNF-alpha (show TNF ELISA Kits) in cerebral vascular endothelial cells.
Nox4 NADPH oxidase (show NOX1 ELISA Kits)-derived reactive oxygen species also initiate a cell survival mechanism by increasing production of carbon monoxide by constitutive heme oxygenase-2 (show HMOX2 ELISA Kits).
This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.
NADPH oxidase 4
, predicted NADPH oxidase-4
, kidney oxidase-1
, kidney superoxide-producing NADPH oxidase
, renal NAD(P)H-oxidase
, superoxide-generating NADPH oxidase 4