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NOXO1 encodes an NADPH oxidase (NOX) organizer, which positively regulates NOX1 and NOX3. Additionally we are shipping NADPH Oxidase Organizer 1 Antibodies (63) and NADPH Oxidase Organizer 1 Kits (2) and many more products for this protein.
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Differential Roles of Protein Complexes NOX1-NOXO1 and NOX2-p47phox in Mediating Endothelial Redox Responses to Oscillatory and Unidirectional Laminar Shear Stress.
Data from pull-down assay between the Noxo1 and Noxa1 (show NOXA1 Proteins) showed that the SH3 domains (Noxa1 (show NOXA1 Proteins)) is responsible for interaction with Noxo1 C-terminal tail harboring proline rich region.
TNF-alpha (show TNF Proteins)/TNFR1 (show TNFRSF1A Proteins) signaling promotes gastric tumorigenesis through induction of Noxo1 and Gna14 (show GNa14 Proteins) in tumor cells.
Phosphorylation of Thr341 allows Noxo1 to sufficiently interact with Noxa1 (show NOXA1 Proteins), an interaction that participates in Nox1 (show NOX1 Proteins) activation
Phorbol myristate acetate stimulates NOXO1 phosphorylation in a transfected human embryonic kidney (HEK (show EPHA3 Proteins)) 293 epithelial cell model via protein kinase C and identify Ser (show SIGLEC1 Proteins)-154 as the major phosphorylated site.
The first quantitative characterization of the interactions made between the cytosolic regulators NOXO1 and NOXA1 (show NOXA1 Proteins) and membrane-bound p22(phox (show CYBA Proteins)), is presented.
NOXO1 and NOXA1 (show NOXA1 Proteins) activate Nox1 (show NOX1 Proteins) without the need for agonist activation, and this is mediated in part by binding of the NOXO1 PX domain to membrane lipids.
NOXO1, p47phox, and p67phox (show NCF2 Proteins) regulate Nox3 (show NOX3 Proteins)
These results suggest that the formation of the complex consisting of Nox1 (show NOX1 Proteins), betaPix (show ARHGEF7 Proteins), and NoxO1 is likely to be a critical step in EGF (show EGF Proteins)-induced ROS (show ROS1 Proteins) generation.
This study shows the expression of alternatively spliced transcripts of the NOXO1 gene and the roles of the protein products in the activation of Nox oxidases.
These findings suggest that Nox activation involves a conformational change leading to disruption of the bis (show BAG3 Proteins)-SH3-PRR (show PVRL1 Proteins) interaction in Noxo1.
NoxO1 stimulates alpha-secretase activity probably through reactive oxygen species-mediated oxidation. Deletion of NoxO1 attenuates Notch (show NOTCH1 Proteins) signaling and thereby promotes a tip-cell phenotype that results in increased angiogenesis.
Genetic susceptibility to alcoholic steatohepatitis was linked to two candidate genes, Noxo1 (and Nlrc4 (show NLRC4 Proteins)).
role in activating superoxide generation by the NADPH oxidase (show NOX1 Proteins) NOX1 (show NOX1 Proteins)
This gene encodes an NADPH oxidase (NOX) organizer, which positively regulates NOX1 and NOX3. The protein contains a PX domain and two SH3 domains. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
NADPH oxidase organizer 1
, NADPH oxidase organizer 1-like
, NADPH oxidase regulatory protein
, Nox organizer 1
, SH3 and PX domain-containing protein 5
, nox-organizing protein 1
, regulatory protein P41NOX
, nox organizer 1
, sorting nexin-28