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NAT1 is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat Nat2 genes. Additionally we are shipping NAT1 Antibodies (78) and NAT1 Proteins (12) and many more products for this protein.
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Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 (show NAT2 ELISA Kits) defined by substrate specificity and inhibitor binding.(
In adipocytes, Nat1 (show EIF4G2 ELISA Kits) silencing lowered insulin (show INS ELISA Kits)-mediated glucose uptake, raised lipolysis, and decreased differentiation. Overexpression did the opposite. Nat1 (show EIF4G2 ELISA Kits)(-) mice had high fasting blood glucose, insulin (show INS ELISA Kits), and triglycerides and low insulin (show INS ELISA Kits) sensitivity.
Transfection assays in mice using hydrodynamics-based procedure and reporter gene assay in a mouse cell line revealed that glucocorticoid-induced NAT (show BRD2 ELISA Kits) gene expression is species dependent
NAT1 (show EIF4G2 ELISA Kits) affects cell growth and morphology
Biochemical analysis demonstrated that mNAT1 and its evolutionarily conserved co-subunit, mARD1, assemble to form a functional acetyltransferase.
Results suggest that peroxynitrite-dependent inactivation of NAT1 (show EIF4G2 ELISA Kits) and 2 may contribute to muscle dysfunction by impairing the biotransformation activity of this key cellular defense enzyme system.
identified a novel endogenous role for human NAT1 (show EIF4G2 ELISA Kits) that might explain some of its effects in cancer cell growth and survival
N-acetyltransferase polymorphisms are associated with risk of lymphoma subtypes.
The association of colorectal adenomas with the rs6983267 variant at 8q24 was considered as 'highly credible', the 'less credible' associations were identified with a further four variants of four independent genes: MTHFR (show MTHFR ELISA Kits) c.677C>T p.A222V(rs1801133), TP53 (show TP53 ELISA Kits) c.215C>G p.R72P (rs1042522), NQO1 (show NQO1 ELISA Kits) c.559C>T p.P187S (rs1800566), and NAT1 (show EIF4G2 ELISA Kits) alleles imputed as fast acetylator genotypes. [meta-analysis]
NAT1 (show EIF4G2 ELISA Kits) genotype affects thioguanine nucleotide levels in patients treated with thiopurines and aminosalicylates and could therefore influence the toxicity and efficacy of these drugs.
NAT1 (show EIF4G2 ELISA Kits) genetic polymorphisms were found to be a risk factor for smokers in the Black population of South Africa with esophageal squamous cell carcinoma.
NAT1 (show EIF4G2 ELISA Kits) has a role in the metabolic pathway of nicotine/cotinine and/or their metabolites.
We report that miR (show MLXIP ELISA Kits)-1290 directly targets the NAT1 (show EIF4G2 ELISA Kits) 3'-UTR (show UTS2R ELISA Kits) and that NAT1 (show EIF4G2 ELISA Kits) protein expression is correlated with improved OS of breast cancer patients.
Arylamine N-acetyltransferase polymorphisms in Han Chinese patients with ankylosing spondylitis and their correlation to the adverse drug reactions to sulfasalazine
Candidate gene NAT1 (show EIF4G2 ELISA Kits) were elevated in male breast cancer biopsies compared to those from female patients without regard to Estrogen Receptors status.
Data suggest that NAT1 (show EIF4G2 ELISA Kits)/NAT2 (show SLC38A1 ELISA Kits) participate in biotransformation of many aromatic/heterocyclic amines; molecular models have been developed regarding acetylation mechanism, active site structure, and substrate/inhibitor-binding specificity. [REVIEW]
This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat Nat2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This enzyme helps metabolize drugs and other xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms have been found for this gene.
N(alpha)-acetyltransferase 15, NatA auxiliary subunit
, N-acetyl transferase 1, liver, blood
, N-acetyltransferase type 1
, arylamide acetylase 1
, arylamine N-acetyltransferase 1
, N-acetyltransferase (arylamine N-acetyltransferase)
, N-acetyltransferase 1 (arylamine N-acetyltransferase)
, monomorphic arylamine N-acetyltransferase
, Arylamide acetylase 1
, Monomorphic arylamine N-acetyltransferase
, NAT1 9
, acetyltransferase AT-I
, arylamine acetyltransferase
, N-acetyltransferase 1
, arylamine N-acetyltransferase