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The protein encoded by NAE1 binds to the beta-amyloid precursor protein. Additionally we are shipping NAE1 Antibodies (104) and many more products for this protein.
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Study shows that APP-BP1 specifically binds the intracellular domain of APP-like (show APP Proteins) protein (APPL (show APP Proteins)), APP-BP1 mutation partially suppresses the abnormal macrochaete phenotype of Appl (show APP Proteins)(d), while overexpression of dAPP-BP1 causes abnormal macrochaetes.
E1 (NAE1 and UBA3 (show UBA3 Proteins)) and E2 (UBC12 (show ube2m Proteins)) enzymes, as well as global NEDD8 (show NEDD8 Proteins) conjugation, were upregulated in over 2/3 of human intrahepatic cholangiocarcinoma
analysis of a metal-based inhibitor of NEDD8 (show NEDD8 Proteins)-activating enzyme
our results suggest that APP-BP1 modulates neuronal differentiation by altering gene expression profiles in fetal neural stem cells
APP-BP1 plays an important role in the cell cycle progression of fetal neural stem cells
APP-BP1 displayed decreased expression levels in HPV-positive head and neck squamous cell carcinoma
structure and mutational analysis of human APPBP1-UBA3 (show UBA3 Proteins), the heterodimeric E1 enzyme (show ENOPH1 Proteins) for NEDD8 (show NEDD8 Proteins)
Conservation in the mechanism of Nedd8 (show NEDD8 Proteins) activation by the human AppBp1-Uba3 (show UBA3 Proteins) heterodimer.
Data report the structure of the quaternary complex between human APPBP1-UBA3 (show UBA3 Proteins), a heterodimeric E1, its ubl NEDD8 (show NEDD8 Proteins), and ATP.
APP-BP1 is degraded by ubiquitin-dependent proteolysis.
The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene.
, NEDD8-activating enzyme E1 regulatory subunit
, NEDD8-activating enzyme E1 subunit
, amyloid beta precursor protein binding protein 1, 59kDa
, amyloid beta precursor protein-binding protein 1, 59 kDa
, amyloid beta precursor protein-binding protein 1, 59kD
, amyloid protein-binding protein 1
, proto-oncogene protein 1
, protooncogene protein 1
, APP-binding protein 1
, amyloid beta precursor protein binding protein 1