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NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans 'never in mitosis A' gene, which controls initiation of mitosis.[supplied by OMIM, Jul 2002].. Additionally we are shipping NEK7 Antibodies (105) and many more products for this protein.
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Human NEK7 Protein expressed in Escherichia coli (E. coli) - ABIN1098444
Kim, Lee, Rhee: NEK7 is a centrosomal kinase critical for microtubule nucleation. in Biochemical and biophysical research communications 2007
Show all 2 references for ABIN1098444
NEK7 serves as a cellular switch that enforces mutual exclusivity of the inflammasome response and cell division.
murine macrophages deficient in Nek7 displayed a largely blunted Nlrp3 (show NLRP3 Proteins) inflammasome response.
NEK7 is an essential protein that acts downstream of potassium efflux to mediate NLRP3 (show NLRP3 Proteins) inflammasome assembly and activation
results confirm Nek7 as a regulator of cell division, and reveal it as an essential component for mammalian growth and survival
During early embryogenesis nek7 is expressed in the site of decidual reaction. Later in embryogenesis, nek7 is highly expressed in the dorsal thalamus.
Studies indicate that NIMA related kinase 7 (NEK7) targets at NLRP3 (show NLRP3 Proteins) protein and involves in the activation of NLRP3 (show NLRP3 Proteins) inflammasome.
Study highlights for the first time the possible role of Nek7 in HCC (show FAM126A Proteins) progression. Nek7 would be a useful biomarker that early predicts HCC (show FAM126A Proteins) patients at higher risk of poor prognosis.
The C-terminal domain of Nek9 (show NEK9 Proteins) activates Nek7 through promoting back-to-back dimerization.
Results show that NEK7 was directly regulated by WHSC1 (show WHSC1 Proteins) through H3K36me2 and its knockdown significantly reduced cell-cycle progression, indicating that NEK7 is a key player in the molecular pathway regulated by WHSC1 (show WHSC1 Proteins).
RGS2 (show RGS2 Proteins) or Nek7 depletion or even overexpression of wild-type or kinase-dead Nek7, reduced gamma-tubulin (show TUBG1 Proteins) from the mitotic spindle poles.
Nek7 increased Ser (show SIGLEC1 Proteins)/Thr (show TRH Proteins) phosphorylation of Anks3 primarily within ankyrin domain.Interaction with Anks3 led to cytoplasmic retention and nuclear exclusion of Nek7.
Nek7, was significantly associated with certain clinicopathologic indices in gallbladder carcinoma
Studies indicate that autophosphorylation of Nek7 and Plk4 (show PLK4 Proteins) occurred through an intermolecular mechanism, the kinases Aurora-A (show AURKA Proteins) and Chk2 (show CHEK2 Proteins) followed an intramolecular mechanism.
NEK7 is essential for PCM (show PCMT1 Proteins) accumulation in a cell cycle stage-specific manner.
NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans 'never in mitosis A' gene, which controls initiation of mitosis.
NIMA-related expressed kinase 7
, NIMA-related kinase 7
, never in mitosis A-related kinase 7
, nimA-related protein kinase 7
, serine/threonine-protein kinase Nek7
, NIMA (never in mitosis gene a)-related kinase 7
, NIMA-family kinase Nek7
, NIMA (never in mitosis gene a)-related expressed kinase 7