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NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans 'never in mitosis A' gene, which controls initiation of mitosis.[supplied by OMIM, Jul 2002].. Additionally we are shipping NEK7 Antibodies (106) and many more products for this protein.
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NEK7 serves as a cellular switch that enforces mutual exclusivity of the inflammasome response and cell division.
murine macrophages deficient in Nek7 displayed a largely blunted Nlrp3 (show NLRP3 Proteins) inflammasome response.
NEK7 is an essential protein that acts downstream of potassium efflux to mediate NLRP3 (show NLRP3 Proteins) inflammasome assembly and activation
results confirm Nek7 as a regulator of cell division, and reveal it as an essential component for mammalian growth and survival
During early embryogenesis nek7 is expressed in the site of decidual reaction. Later in embryogenesis, nek7 is highly expressed in the dorsal thalamus.
Results demonstrate that NEK7 is involved in the timely regulation of G1 progression, S-phase entry, and procentriole formation.
Signaling cascade of the NIMA-related kinases (Neks) Nek6, Nek7, and Nek9 is required for the localization and function of two kinesins essential for cytokinesis, Mklp2 and Kif14 to properly coordinate cytokinesis.
TRF1 (show TERF1 Proteins) phosphorylation by Nek7 favors the binding of shelterin protein TIN2 (show TINF2 Proteins) and disfavors E3 ligase Fbx4 (show FBXO4 Proteins) interaction, thus preventing TRF1 (show TERF1 Proteins) ubiquitination and proteasome degradation to maintain telomere integrity.
Studies indicate that NIMA related kinase 7 (NEK7) targets at NLRP3 (show NLRP3 Proteins) protein and involves in the activation of NLRP3 (show NLRP3 Proteins) inflammasome.
Study highlights for the first time the possible role of Nek7 in HCC (show FAM126A Proteins) progression. Nek7 would be a useful biomarker that early predicts HCC (show FAM126A Proteins) patients at higher risk of poor prognosis.
The C-terminal domain of Nek9 (show NEK9 Proteins) activates Nek7 through promoting back-to-back dimerization.
Results show that NEK7 was directly regulated by WHSC1 (show WHSC1 Proteins) through H3K36me2 and its knockdown significantly reduced cell-cycle progression, indicating that NEK7 is a key player in the molecular pathway regulated by WHSC1 (show WHSC1 Proteins).
RGS2 (show RGS2 Proteins) or Nek7 depletion or even overexpression of wild-type or kinase-dead Nek7, reduced gamma-tubulin (show TUBG1 Proteins) from the mitotic spindle poles.
Nek7 increased Ser (show SIGLEC1 Proteins)/Thr (show TRH Proteins) phosphorylation of Anks3 primarily within ankyrin domain.Interaction with Anks3 led to cytoplasmic retention and nuclear exclusion of Nek7.
NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans 'never in mitosis A' gene, which controls initiation of mitosis.
NIMA-related expressed kinase 7
, NIMA-related kinase 7
, never in mitosis A-related kinase 7
, nimA-related protein kinase 7
, serine/threonine-protein kinase Nek7
, NIMA (never in mitosis gene a)-related kinase 7
, NIMA-family kinase Nek7
, NIMA (never in mitosis gene a)-related expressed kinase 7