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NKRF encodes a transcriptional repressor that interacts with specific negative regulatory elements to mediate transcriptional repression of certain nuclear factor kappa B responsive genes. Additionally we are shipping NFKB Repressing Factor Antibodies (44) and NFKB Repressing Factor Kits (8) and many more products for this protein.
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vitamin E supplementation affords protection by decreasing MMP-1 (show MMP1 Proteins) and increasing PPARg (show PPARG Proteins), GSTa (show GSTa2 Proteins), and ABCA1 (show ABCA1 Proteins) levels in aortae of rabbits fed a cholesterol-rich diet
MIR29 targets and reduces expression of CLDN1 (show CLDN1 Proteins) and NKRF to increase intestinal permeability in inflammatory bowel disease.
The data of this study show that JKTBP1 and the 14-nt element act independently to mediate NRF internal ribosome entry segment activity.
depletion of NKRF, XRN2 (show XRN2 Proteins) or DHX15 (show DHX15 Proteins) impairs an early pre-rRNA cleavage step.
NF-kappaB-repressing factor (NKRF) phosphorylation modulates promoter-proximal transcription elongation of NF-kappaB (show NFKB1 Proteins)/NKRF-regulated genes via direct interactions with elongation complex in response to specific stimuli
The up-regulated NKRF serves as an endogenous repressor for IP-10 (show CXCL10 Proteins) and IL-8 (show IL8 Proteins) synthesis to hinder host from robust response to MTb (show NCAPG2 Proteins) infection.
NRF may serve as an endogenous repressor to prevent robust increase in IP-10/CXCL10 (show CXCL10 Proteins) and IL-8/CXCL8 (show IL8 Proteins) when TB bacterial load is high.
The expression of NKRF is decreased in PBMCs of patients with stable COPD (show ARCN1 Proteins). The downregulation of NKRF was found to be closely related to enhanced IL-8 (show IL8 Proteins) production from these peripheral blood cells through de-repression of the IL-8 (show IL8 Proteins) promoter.
The results indicate that JKTBP1 regulates the level of NRF protein expression by binding to both NRF 5' and 3' UTRs.
role of NF-kappa B-repressing factor (NRF) in basal repression of the hiNOS gene
cDNA is 3247 bp long, contains three exons and maps to human chromosome Xq24. NRF is widely expressed in human tissues.
Full-length NRF is highly enriched in nucleoli and only a small fraction of NRF is found in the nucleoplasm and cytoplasm
GRK5 overexpression causes nuclear accumulation of IkappaB alpha, leading to the inhibition of NFkappaB transcriptional activity.
This gene encodes a transcriptional repressor that interacts with specific negative regulatory elements to mediate transcriptional repression of certain nuclear factor kappa B responsive genes. The protein localizes predominantly to the nucleolus with a small fraction found in the nucleoplasm and cytoplasm. Alternate splicing results in multiple transcript variants.
NFKB repressing factor
, transcription factor NRF
, NF-kappaB repressing factor
, nkrf (NF-kappaB repressing factor)
, NF-kappa-B-repressing factor-like
, NF-kappa-B-repressing factor
, NFkB-repressing factor