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NAB2 encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. Additionally we are shipping NGFI-A Binding Protein 2 (EGR1 Binding Protein 2) Proteins (5) and NGFI-A Binding Protein 2 (EGR1 Binding Protein 2) Kits (3) and many more products for this protein.
Showing 10 out of 98 products:
Human Polyclonal NAB2 Primary Antibody for WB - ABIN391957
Srinivasan, Mager, Ward, Mayer, Svaren: NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex. in The Journal of biological chemistry 2006
Show all 3 references for ABIN391957
Human Polyclonal NAB2 Primary Antibody for IHC, ELISA - ABIN1533922
Kirsch, Korradi, Johnson: Mader: a novel nuclear protein over expressed in human melanomas. in Oncogene 1996
Show all 2 references for ABIN1533922
Cow (Bovine) Polyclonal NAB2 Primary Antibody for WB - ABIN2780731
Olsen, Blagoev, Gnad, Macek, Kumar, Mortensen, Mann: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. in Cell 2006
Data suggest that histone deacetylase (show HDAC1 Antibodies) inhibitors inhibit the induction of NGF1A-binding protein (show NAB1 Antibodies) Nab2 by brain derived neurotrophic factor (BDNF (show BDNF Antibodies)), and thereby the relative induction of dopamine and cyclic AMP-regulated phosphoprotein (show ARPP21 Antibodies), 32 kDa (DARPP-32 (show PPP1R1B Antibodies)).
Nab2 is a novel endogenous negative regulator of Egr-1 (show EGR1 Antibodies)-dependent TGF-beta (show TGFB1 Antibodies) signaling responsible for setting the intensity of fibrotic responses
Nab1 and Nab2 proteins are necessary for Schwann cells to exit the cell cycle, downregulate suppressed cAMP-inducible protein (SCIP) expression and upregulate expression of critical myelination genes.
repression of the endogenous Rad (show RRAD Antibodies) gene by NAB2 involves interaction with the CHD4 (chromodomain helicase DNA-binding protein 4 (show CHD4 Antibodies)) subunit of the NuRD (nucleosome remodeling and deacetylase) chromatin remodeling complex
NAB2 enhances IL-2 (show IL2 Antibodies) transcription by acting as a coactivator for Egr-1 (show EGR1 Antibodies).NAB2 is recruited to the Egr-1 (show EGR1 Antibodies) binding site of the IL-2 (show IL2 Antibodies) promoter.
We report here, that FGF23 (show FGF23 Antibodies) induces not only Egr-1 (show EGR1 Antibodies) but also two isoforms of NAB2, which are specific co-repressors of Egr-1 (show EGR1 Antibodies).
The detection of nuclear relocation of STAT6 (show STAT6 Antibodies) with immunohistochemistry is a characteristic of solitary fibrous tumours (SFTs), and may serve as a diagnostic marker that indicates NAB2-STAT6 (show STAT6 Antibodies) fusion and helps to discriminate SFTs from histological mimics.
Variants of the NAB2-STAT6 (show STAT6 Antibodies) fusion gene are found in solitary fibrous tumors of the meninges.
NAB2-STAT6 (show STAT6 Antibodies) fusion is a diagnostic tumor marker for papillary' solitary fibrous tumor/hemangiopericytoma of brain.
the majority of intrathoracic SFTs exhibited STAT6 (show STAT6 Antibodies) nuclear staining, and NAB2ex4-STAT6ex2/3 was the predominant fusion type.
Case Report: NAB2-STAT6 (show STAT6 Antibodies) fusion in glioblastoma.
We delineate the common and rare NAB2-STAT6 (show STAT6 Antibodies) fusion variants in solitary fibrous tumors
This study confirms that meningeal Meningeal solitary fibrous tumor and hemangiopericytoma represent a histopathologic continuum linked by STAT6 (show STAT6 Antibodies) nuclear expression and NAB2-STAT6 (show STAT6 Antibodies) fusion similar to their soft tissue counterparts.
This study validated the existence of the NAB2-STAT6 (show STAT6 Antibodies) fusion gene in solitary fibrous tumors and examined its relation with pathological features.
also identified NAB2-STAT6 (show STAT6 Antibodies) fusions in two hemangiopericytomas diagnosed in the past with a common variant of NAB2ex6-STAT6ex16/17
There was no association between solitary fibrous tumors with either NAB2 exon 4-STAT6 (show STAT6 Antibodies) exon 2 or 3 fusion and tumors with other fusions regarding the frequency of mutations in the examined genes (P = .201).
This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
NGFI-A binding protein 2 (EGR1 binding protein 2)
, EGR-1-binding protein 2
, NGFI-A binding protein 2 (EGR-1 binding protein 2)
, NGFI-A-binding protein 2
, EGR1 binding protein 2
, melanoma-associated delayed early response protein