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Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Additionally we are shipping NIMA (Never in Mitosis Gene A)- Related Kinase 9 Proteins (6) and NIMA (Never in Mitosis Gene A)- Related Kinase 9 Kits (4) and many more products for this protein.
Showing 10 out of 128 products:
Human Polyclonal NEK9 Primary Antibody for IHC (p), WB - ABIN392654
Tan, Lee: Nek9, a novel FACT-associated protein, modulates interphase progression. in The Journal of biological chemistry 2004
Show all 5 references for ABIN392654
Human Monoclonal NEK9 Primary Antibody for IF, ELISA - ABIN566652
König, Probst-Kepper, Reinl, Jeron, Huehn, Schraven, Jänsch: First insight into the kinome of human regulatory T cells. in PLoS ONE 2012
Dog (Canine) Polyclonal NEK9 Primary Antibody for WB - ABIN2783588
Pelka, Scimè, Mandalfino, Joch, Abdulla, Whyte: Adenovirus E1A proteins direct subcellular redistribution of Nek9, a NimA-related kinase. in Journal of cellular physiology 2007
requirement for Nek8 (show NEK8 Antibodies) in left-right patterning is conserved
Nek8 (show NEK8 Antibodies) acts downstream of Inv (show INVS Antibodies) function
cross-species analysis between zebrafish and mouse demonstrates taht NEK8 (show NEK8 Antibodies) has a role in development of pronephric cysts
Nercc1 contributes to both the centrosomal and the chromatin/Ran pathways that collaborate in the organization of a bipolar spindle
NEK9 is a critical component of the replication stress response that promotes CHK1 (show CHEK1 Antibodies) activity, maintaining genome integrity following challenges to DNA replication.
Knockdown of Nek9 also impaired the spindle-pole localization of gamma-tubulin (show TUBG1 Antibodies) and resulted in retention of the spindle assembly checkpoint protein Bub3 (show BUB3 Antibodies) at the kinetochores.
Overall, these results highlight the complexity of virus-host interactions and identify a new role for the cellular protein Nek9 during human adenovirus infection, suggesting a role for Nek9 in regulating p53 (show TP53 Antibodies) target gene expression.
The C-terminal domain of Nek9 activates Nek7 (show NEK7 Antibodies) through promoting back-to-back dimerization.
The findings demonstrate that a novel NEK9 network regulates the growth of cancer cells lacking functional p53 (show TP53 Antibodies).
NEK9 inhibition represents a novel anti-cancer strategy by induction of mitotic catastrophe via impairment of spindle dynamics, cytokinesis and mitotic checkpoint (show BUB3 Antibodies) control.
Structural analysis of LC8 (show DYNLL1 Antibodies) with both Nek9 peptides, together with different biophysical experiments, explains the observed diminished binding affinity of Nek9 to LC8 (show DYNLL1 Antibodies) upon phosphorylation on Ser (show SIGLEC1 Antibodies)(944) within the Nek9 sequence
Nek9 phosphorylates NEDD1 (show NEDD1 Antibodies) on Ser377 driving its recruitment and thereby that of gamma-tubulin (show TUBG1 Antibodies) to the centrosome in mitotic cells.
The interaction between the human NimA-like protein kinase (show CDK7 Antibodies) Nek9 and the Helicobacter HcpC has been validated by ELISA and surface plasmon resonance.
Nek9 is a Plk1 (show PLK1 Antibodies)-activated kinase that controls early centrosome separation through Nek6 (show NEK6 Antibodies)/7 and Eg5 (show KIF11 Antibodies).
DYNLL/LC8 (show DYNLL1 Antibodies) protein controls signal transduction through the Nek9/Nek6 (show NEK6 Antibodies) signaling module by regulating Nek6 (show NEK6 Antibodies) binding to Nek9.
binds the Ran GTPase (show RAN Antibodies) and regulates mitotic progression
Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (By similarity).
serine/threonine-protein kinase Nek9
, NIMA-related kinase 8
, never in mitosis A-related kinase 8
, nimA-related protein kinase 8
, serine/threonine-protein kinase Nek8
, NIMA (never in mitosis gene a)- related kinase 8
, NIMA (never in mitosis gene a)- related kinase 9
, NIMA (never in mitosis gene a)-related expressed kinase 8
, serine/threonine-protein kinase Nek9-like
, nercc1 kinase
, never in mitosis A-related kinase 9
, nimA-related protein kinase 9
, NIMA-related kinase Nek8
, nimA-related kinase 8
, NIMA-family kinase Nercc1