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NIMA (Never in Mitosis Gene A)-Related Kinase 2 Proteins (NEK2)

NEK2 encodes a serine/threonine-protein kinase that is involved in mitotic regulation. Additionally we are shipping NEK2 Antibodies (136) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NEK2 18005 O35942
Rat NEK2 NEK2 114482  
NEK2 4751 P51955
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Top NEK2 Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human Un-conjugated 5 μg Log in to see 2 to 3 Days
$336.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details
HOST_Sf-9 cells Human Un-conjugated   5 μg Log in to see 3 to 4 Days
$571.07
Details

NEK2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , ,
,

More Proteins for NIMA (Never in Mitosis Gene A)-Related Kinase 2 (NEK2) Interaction Partners

Mouse (Murine) NIMA (Never in Mitosis Gene A)-Related Kinase 2 (NEK2) interaction partners

  1. Cep85 is a bona fide Nek2A-binding partner that surrounds the proximal ends of centrioles where it cooperates with PP1gamma (also known as PPP1CC (show PPP1CC Proteins)) to antagonize Nek2A

  2. The results suggest that overexpression of NEK2 has the potential to serve as a biomarker for PCa (show ENPP1 Proteins) prognosis.

  3. Nek2 transgenic mice develop spontaneous germinal centers and exhibit an enhanced T cell dependent immune response our data demonstrates a novel role for Nek2 in regulating B cell development and the immune response

  4. these data indicate that Nek2 has a pivotal role in breast cancer growth at primary and secondary sites, and thus may be an attractive and novel therapeutic target for this disease.

  5. CIP2A (show KIAA1524 Proteins) strongly interacts with NEK2 during G2/M phase, thereby enhancing NEK2 kinase activity to facilitate centrosome separation in a PP1 (show PPP1CC Proteins)- and PP2A (show PPP2R2B Proteins)-independent manner.

  6. Nek2 and its substrate, centrobin/Nip2, are required for proper meiotic spindle formation of the mouse oocytes

  7. Data show that NEK2 was identified as a tumor-associated antigen.

  8. Nek2 may be a mitotic regulator that is involved in diverse cell cycle events.

  9. Tcp10 promoter-directed expression of the Nek2 gene in mouse meiotic spermatocytes.

  10. The MAPK (show MAPK1 Proteins) pathway triggers activation of Nek2 during chromosome condensation in mouse spermatocytes.

Human NIMA (Never in Mitosis Gene A)-Related Kinase 2 (NEK2) interaction partners

  1. Suggest elevated Nek2 protein expression may be an independent risk factor for colon cancer.

  2. Hepatocellular carcinoma patients with high NEK2 expression had significantly poor recurrence-free survival (p=0.042) and early recurrence after hepatectomy.

  3. Cep85 is a bona fide Nek2A-binding partner that surrounds the proximal ends of centrioles where it cooperates with PP1gamma (also known as PPP1CC (show PPP1CC Proteins)) to antagonize Nek2A

  4. Kif24 is a physiological substrate of Nek2, which regulates cilia disassembly through a concerted mechanism involving Kif24-mediated microtubule depolymerization.

  5. The results suggest that overexpression of NEK2 has the potential to serve as a biomarker for PCa (show FLVCR1 Proteins) prognosis.

  6. Nek2A is degraded in mitosis regardless of enforced spindle checkpoint activation

  7. we highlight recent findings on the aberrant expression and functional significance of NEK2A in human cancers and emphasize their significance for therapeutic potentials.

  8. Findings are consistent with the hypothesis that NEK2 contributes to ALDH1A1 (show ALDH1A1 Proteins)-dependent drug resistance in myeloma

  9. Nek2 was demonstrated to phosphorylate Cep68 in vivo and this phosphorylation appears to promote Cep68 degradation in mitosis.

  10. Nek2 plays a central role in proteasome-mediated cell cycle regulation and in conferring resistance to bortezomib in cancer cells.

NEK2 Protein Profile

Protein Summary

This gene encodes a serine/threonine-protein kinase that is involved in mitotic regulation. This protein is localized to the centrosome, and undetectable during G1 phase, but accumulates progressively throughout the S phase, reaching maximal levels in late G2 phase. Alternatively spliced transcript variants encoding different isoforms with distinct C-termini have been noted for this gene.

Gene names and symbols associated with NEK2

  • NIMA (never in mitosis gene a)-related kinase 2 (NEK2)
  • NIMA (never in mitosis gene a)-related expressed kinase 2 (Nek2)
  • NIMA-related kinase 2 (NEK2)
  • serine/threonine-protein kinase Nek2 (NEK2)
  • AA617254 protein
  • ATNEK2 protein
  • C77054 protein
  • HsPK21 protein
  • NEK2A protein
  • NIMA-RELATED KINASE2 protein
  • NIMA-related kinase 2 protein
  • NLK1 protein
  • T9J14.24 protein
  • T9J14_24 protein

Protein level used designations for NEK2

NIMA (never in mitosis gene a)-related kinase 2 , NIMA - related expressed kinase 2 , NIMA-related expressed kinase 2 , NIMA-related kinase 2 , Nek2 kinase , never in mitosis A-related kinase 2 , nimA-related protein kinase 2 , serine/threonine-protein kinase Nek2 , serine/threonine protein kinase Nek2 , nimA-like protein kinase 1

GENE ID SPECIES
100540058 Meleagris gallopavo
18005 Mus musculus
114482 Rattus norvegicus
480021 Canis lupus familiaris
397258 Sus scrofa
523998 Bos taurus
4751 Homo sapiens
819641 Arabidopsis thaliana
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