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The protein encoded by NEK6 is a kinase required for progression through the metaphase portion of mitosis. Additionally we are shipping NEK6 Antibodies (72) and NEK6 Proteins (14) and many more products for this protein.
NEK6 is overexpressed in various human cancer tissues, and ectopic expression of NEK6 increases tumor promoter-induced transformation of JB6 Cl41 mouse epidermal cells.
During early embryogenesis nek6 is highly expressed in primary giant trophoblast cells. Later in embryogenesis, nek6 is found in ventricular and sub-ventricular regions.
NEK6 forms heterodimers with NEK4 and NEK5 to regulate cortical microtubule organization possibly through the phosphorylation of beta-tubulins.
overexpression of PAK1 (show PAK1 ELISA Kits), NEK6, AURKA (show AURKA ELISA Kits), and AURKB (show AURKB ELISA Kits) genes in patients with Colorectal adenomatous polyp and colorectal cancer in the Turkish population.
We found that NEK6-mediated phosphorylation of TPP1 (show TPP1 ELISA Kits) Ser255 in G2/M phase regulates the association between telomerase activity and TPP1 (show TPP1 ELISA Kits). Furthermore, we found evidence that POT1 (show POT1 ELISA Kits) negatively regulates TPP1 (show TPP1 ELISA Kits) phosphorylation because the level of Ser255 phosphorylation was elevated when telomeres were elongated by a POT1 (show POT1 ELISA Kits) mutant lacking its OB-fold domains
Overexpression of AURKA (show AURKA ELISA Kits) and NEK6 genes was significantly more pronounced in Ulcerative colitis patients with more extensive colon involvement
NEK6 suppresses the cell growth arrest induced by TGFbeta (show TGFB1 ELISA Kits). Mechanically, NEK6 blocks nuclear translocation of Smad4 (show SMAD4 ELISA Kits), which is essential for TGFbeta (show TGFB1 ELISA Kits) function.
Nek6 is also a critical signaling molecule that helps prevent cardiac hypertrophy and inhibits the Akt (show AKT1 ELISA Kits) signaling pathway.
Nek6 facilitates association of Hsp72 (show HSPA1A ELISA Kits) with the mitotic spindle, where it promotes stable K-fiber assembly through recruitment of the ch-TOG (show CKAP5 ELISA Kits)-TACC3 (show TACC3 ELISA Kits) complex.
Nek6 plays an important role in the premature senescence of cancer cells.
High Nek6 is associated with hepatic cell cancer.
Nek9 (show NEK9 ELISA Kits) is a Plk1 (show PLK1 ELISA Kits)-activated kinase that controls early centrosome separation through Nek6/7 and Eg5 (show KIF11 ELISA Kits).
These results suggest that the increased expression of Nek6 renders cancer cells resistant to premature senescence, and targeting Nek6 could be an efficient strategy for cancer treatment.
The protein encoded by this gene is a kinase required for progression through the metaphase portion of mitosis. Inhibition of the encoded protein can lead to apoptosis. This protein also can enhance tumorigenesis by suppressing tumor cell senescence. Several transcript variants encoding a few different isoforms have been found for this gene.
NIMA-related expressed kinase 6
, never in mitosis A-related kinase 6
, nimA-related protein kinase 6
, serine/threonine-protein kinase Nek6
, putative serine-threonine protein kinase
, NIMA (never in mitosis gene a)-related kinase 6
, protein kinase SID6-1512
, NIMA (never in mitosis gene a)-related expressed kinase 6