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NIMA-Related Kinase 1 Proteins (NEK1)

The protein encoded by NEK1 is a serine/threonine kinase involved in cell cycle regulation. Additionally we are shipping NEK1 Antibodies (25) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NEK1 18004 P51954
NEK1 4750 Q96PY6
Rat NEK1 NEK1 290705  
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Top NEK1 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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HOST_Baculovirus infected Insect Cells Mouse GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details

NEK1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
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Human ,
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More Proteins for NIMA-Related Kinase 1 (NEK1) Interaction Partners

Mouse (Murine) NIMA-Related Kinase 1 (NEK1) interaction partners

  1. Nek1 is detectable in all murine tissues but its expression in wild type and kat2J heterozygous kidneys decrease as the kidneys mature. In the embryonic kidney, Nek1 expression is most prominent in cells that will become podocytes and proximal tubules.

  2. results demonstrate that Nek1 is important for proper checkpoint control and characterize for the first time a DNA damage response that does not directly involve one of the known upstream mediator kinases, ATM or ATR

  3. data suggest that TAZ (show TAZ Proteins) and Nek1 constitute a negative feedback loop linked through phosphorylation and ubiquitination and that the interaction of Nek1 and TAZ (show TAZ Proteins) maintain polycystin 2 (show PKD2 Proteins) at the level needed for proper ciliogenesis

  4. NEK1 is required for the maintenance of genome stability by acting at multiple junctures, including control of chromosome stability

  5. Nek1 may function as a kinase early in the DNA damage response pathway.

  6. Murine NIMA-related kinase, Nek1, is larger than previously reported, and that the full-length protein conserves the structural hallmarks of NIMA

  7. Nek1 links cell cycle progression and the primary cilium cycle.

  8. we propose that Nek1 plays a role in centrosome integrity, affecting both ciliogenesis and centrosome stability

  9. These data show that Nek1 is important for efficient DNA damage checkpoint control and for proper DNA damage repair.

  10. NEK1 is a candidate to transduce messages from the ciliary-basal body region to the regulation of nuclear gene expression.

Human NIMA-Related Kinase 1 (NEK1) interaction partners

  1. C21ORF2 (show C21orf2 Proteins) functions in the same pathway as NEK1 in DNA damage repair.

  2. Nek1 may facilitate S-phase progression by interacting with Ku80 (show XRCC5 Proteins) and regulating chromatin loading of replication factors.

  3. Nek1 may suppress cilia by phosphorylating pVHL (show VHL Proteins), which is critical to microtubule stabilization and ciliary stability.

  4. as an ATR (show ANTXR1 Proteins)-associated kinase, Nek1 enhances the stability and activity of ATR (show ANTXR1 Proteins)-ATRIP (show ATRIP Proteins) before DNA damage, priming ATR (show ANTXR1 Proteins)-ATRIP (show ATRIP Proteins) for a robust DNA damage response

  5. The present case provides evidence for a correlation of NEK1 mutation with short rib-polydactyly syndrome type II (Majewski.

  6. This study confirms that NEK1 is one gene causing SRP type II but also reports mutations in DYNC2H1, expanding the phenotypic spectrum of DYNC2H1 mutations.

  7. results demonstrate that Nek1 is important for proper checkpoint control and characterize for the first time a DNA damage response that does not directly involve one of the known upstream mediator kinases, ATM or ATR

  8. absence of functional full-length NEK1 severely reduces cilia number and alters ciliar morphology in vivo.

  9. Nek1 is involved in the beginning of the cellular response to genotoxic stress and plays an important role in preventing cell death induced by DNA damage.

  10. Data report that NEK1 and CLASP2 (show CLASP2 Proteins) colocalize with FEZ1 (show LZTS1 Proteins) in a perinuclear region in mammalian cells, and observed that coiled-coil interactions occur between FEZ1 (show LZTS1 Proteins)/CLASP2 (show CLASP2 Proteins) and FEZ1 (show LZTS1 Proteins)/NEK1 in vitro.

NEK1 Protein Profile

Protein Summary

The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with NIMA-Related Kinase 1 Proteins (NEK1)

  • NIMA (never in mitosis gene a)-related expressed kinase 1 (Nek1)
  • NIMA (never in mitosis gene a)-related kinase 1 (NEK1)
  • NIMA-related kinase 1 (NEK1)
  • NIMA-related kinase 1 (Nek1)
  • serine/threonine-protein kinase Nek1 (NEK1)
  • ATNEK1 protein
  • D8Ertd790e protein
  • F20D21.32 protein
  • F20D21_32 protein
  • kat protein
  • NIMA-RELATED KINASE1 protein
  • NIMA-related serine/threonine kinase 1 protein
  • NY-REN-55 protein
  • SRPS2 protein
  • SRPS2A protein

Protein level used designations for NIMA-Related Kinase 1 Proteins (NEK1)

NIMA-related kinase 1 , NY-REN-55 antigen , Nek1 serine/threonine- and tyrosine-specific protein kinase , kidney, anemia and testis , never in mitosis A-related kinase 1 , nimA-related protein kinase 1 , serine/threonine-protein kinase Nek1 , NIMA (never in mitosis gene a)-related kinase 1 , protein-serine/threonine kinase , renal carcinoma antigen NY-REN-55 , NIMA (never in mitosis gene a)-related expressed kinase 1

GENE ID SPECIES
18004 Mus musculus
486058 Canis lupus familiaris
4750 Homo sapiens
534671 Bos taurus
290705 Rattus norvegicus
841893 Arabidopsis thaliana
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