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The protein encoded by NEK1 is a serine/threonine kinase involved in cell cycle regulation. Additionally we are shipping NEK1 Antibodies (29) and many more products for this protein.
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Nek1 is detectable in all murine tissues but its expression in wild type and kat2J heterozygous kidneys decrease as the kidneys mature. In the embryonic kidney, Nek1 expression is most prominent in cells that will become podocytes and proximal tubules.
results demonstrate that Nek1 is important for proper checkpoint control and characterize for the first time a DNA damage response that does not directly involve one of the known upstream mediator kinases, ATM or ATR
data suggest that TAZ (show TAZ Proteins) and Nek1 constitute a negative feedback loop linked through phosphorylation and ubiquitination and that the interaction of Nek1 and TAZ (show TAZ Proteins) maintain polycystin 2 (show PKD2 Proteins) at the level needed for proper ciliogenesis
NEK1 is required for the maintenance of genome stability by acting at multiple junctures, including control of chromosome stability
Nek1 may function as a kinase early in the DNA damage response pathway.
Murine NIMA-related kinase, Nek1, is larger than previously reported, and that the full-length protein conserves the structural hallmarks of NIMA
Nek1 links cell cycle progression and the primary cilium cycle.
we propose that Nek1 plays a role in centrosome integrity, affecting both ciliogenesis and centrosome stability
These data show that Nek1 is important for efficient DNA damage checkpoint control and for proper DNA damage repair.
NEK1 is a candidate to transduce messages from the ciliary-basal body region to the regulation of nuclear gene expression.
C21ORF2 (show C21orf2 Proteins) functions in the same pathway as NEK1 in DNA damage repair.
Nek1 may facilitate S-phase progression by interacting with Ku80 (show XRCC5 Proteins) and regulating chromatin loading of replication factors.
Nek1 may suppress cilia by phosphorylating pVHL (show VHL Proteins), which is critical to microtubule stabilization and ciliary stability.
as an ATR (show ANTXR1 Proteins)-associated kinase, Nek1 enhances the stability and activity of ATR (show ANTXR1 Proteins)-ATRIP (show ATRIP Proteins) before DNA damage, priming ATR (show ANTXR1 Proteins)-ATRIP (show ATRIP Proteins) for a robust DNA damage response
The present case provides evidence for a correlation of NEK1 mutation with short rib-polydactyly syndrome type II (Majewski.
This study confirms that NEK1 is one gene causing SRP type II but also reports mutations in DYNC2H1, expanding the phenotypic spectrum of DYNC2H1 mutations.
absence of functional full-length NEK1 severely reduces cilia number and alters ciliar morphology in vivo.
Nek1 is involved in the beginning of the cellular response to genotoxic stress and plays an important role in preventing cell death induced by DNA damage.
Data report that NEK1 and CLASP2 (show CLASP2 Proteins) colocalize with FEZ1 (show LZTS1 Proteins) in a perinuclear region in mammalian cells, and observed that coiled-coil interactions occur between FEZ1 (show LZTS1 Proteins)/CLASP2 (show CLASP2 Proteins) and FEZ1 (show LZTS1 Proteins)/NEK1 in vitro.
The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have been found for this gene.
NIMA-related kinase 1
, NY-REN-55 antigen
, Nek1 serine/threonine- and tyrosine-specific protein kinase
, kidney, anemia and testis
, never in mitosis A-related kinase 1
, nimA-related protein kinase 1
, serine/threonine-protein kinase Nek1
, NIMA (never in mitosis gene a)-related kinase 1
, protein-serine/threonine kinase
, renal carcinoma antigen NY-REN-55
, NIMA (never in mitosis gene a)-related expressed kinase 1