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NEK8 encodes a member of the serine/threionine protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans. Additionally we are shipping NEK8 Proteins (5) and many more products for this protein.
Showing 10 out of 84 products:
Human Polyclonal NEK8 Primary Antibody for EIA, WB - ABIN359201
Valkova, Yunis, Mak, Kang, Kültz: Nek8 mutation causes overexpression of galectin-1, sorcin, and vimentin and accumulation of the major urinary protein in renal cysts of jck mice. in Molecular & cellular proteomics : MCP 2005
Show all 3 references for ABIN359201
Human Polyclonal NEK8 Primary Antibody for EIA, WB - ABIN359200
Bowers, Boylan: Nek8, a NIMA family kinase member, is overexpressed in primary human breast tumors. in Gene 2004
Show all 3 references for ABIN359200
Human Polyclonal NEK8 Primary Antibody for WB - ABIN391137
Holland, Milne, Garka, Johnson, Willis, Sims, Rauch, Bird, Virca: Purification, cloning, and characterization of Nek8, a novel NIMA-related kinase, and its candidate substrate Bicd2. in The Journal of biological chemistry 2002
Show all 2 references for ABIN391137
NEK8-depleted inner medullary collecting duct cells exhibited a defective response to fluid shear.
Nek8 acts downstream of Inv (show INVS Antibodies) function
Inv (show INVS Antibodies) acts as a molecular anchor for Nphp3 (show NPHP3 Antibodies) and Nek8 in the proximal segment of primary cilia.
cross-species analysis between zebrafish and mouse demonstrates taht NEK8 has a role in development of pronephric cysts
Nek8 and Pkd1 (show PKD1 Antibodies) genes function in a common pathway to regulate cystogenesis. Moreover, compound Pkd1 (show PKD1 Antibodies) and Nek8 heterozygous adult mice develop a more aggressive cystic disease than animals with a mutation in either gene alone.
Defects in ciliary localization of Nek8 is associated with polycystic kidney diseases
requirement for Nek8 in left-right patterning is conserved
The mutations: c.2069_2070insC variant (p.Ter693LeufsTer86), and a c.1043C>T variant (p.Thr348Met) in RCC1 (show RCC1 Antibodies) domain of NEK8 (show NEK9 Antibodies) in two brothers with cardiac, renal, and hepatic anomalies
our study demonstrates that NEK8 (show NEK9 Antibodies) human mutations cause major organ developmental defects due to altered ciliogenesis and cell differentiation/proliferation through deregulation of the Hippo pathway
NEK8 (show NEK9 Antibodies) may be a new target gene of HIFs; pVHL (show VHL Antibodies) can down-regulate NEK8 (show NEK9 Antibodies) via HIFs to maintain the primary cilia structure in human renal cancer cells
NEK8 (show NEK9 Antibodies) is essential for organ development and that the complete loss of NEK8 (show NEK9 Antibodies) perturbs multiple signalling pathways resulting in a severe early embryonic phenotype.
Mutation in NEK8 (show NEK9 Antibodies) is associated with renal ciliopathies
ANKS6 (show ANKS6 Antibodies) as a new NPHP family member that assembles a distinct module of nephronophthisis-associated proteins, encompassing NEK8 (show NEK9 Antibodies), INVS (show INVS Antibodies) and NPHP3 (show NPHP3 Antibodies).
NPHP9 promotes signalling through the transcriptional co-activator TAZ (show TAZ Antibodies).
study finds that induction of ciliogenesis upon cell cycle exit is accompanied by both activation and proteasomal degradation of Nek8 (show NEK9 Antibodies), and that activation is dependent upon phosphorylation within the catalytic domain
Data demonstrate for the first time that Nek8 (show NEK9 Antibodies) is a novel tumor associated gene, and shares considerable sequence homology with the Nek family of protein kinases and may be involved in G(2)/M progression.
This gene encodes a member of the serine/threionine protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans. The encoded protein may play a role in cell cycle progression from G2 to M phase. Mutations in the related mouse gene are associated with a disease phenotype that closely parallels the juvenile autosomal recessive form of polycystic kidney disease in humans.
serine/threonine-protein kinase Nek8
, NIMA-related expressed kinase 8
, juvenile cystic kidney
, never in mitosis A-related kinase 8
, nimA-related protein kinase 8
, NIMA-related kinase 8
, NIMA (never in mitosis gene a)- related kinase 8
, NIMA-family kinase NEK8
, NIMA-related kinase 12a
, nephrocystin 9
, nima-related protein kinase 12a
, serine/thrionine-protein kinase NEK8
, NIMA (never in mitosis gene a)-related expressed kinase 8