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NIMA-Related Kinase 8 Proteins (NEK8)

NEK8 encodes a member of the serine/threionine protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans. Additionally we are shipping NEK8 Antibodies (82) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NEK8 140859 Q91ZR4
NEK8 284086 Q86SG6
Rat NEK8 NEK8 287473  
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Top NEK8 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details

NEK8 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

More Proteins for NIMA-Related Kinase 8 (NEK8) Interaction Partners

Mouse (Murine) NIMA-Related Kinase 8 (NEK8) interaction partners

  1. NEK8-depleted inner medullary collecting duct cells exhibited a defective response to fluid shear.

  2. Nek8 acts downstream of Inv (show INVS Proteins) function

  3. Inv (show INVS Proteins) acts as a molecular anchor for Nphp3 (show NPHP3 Proteins) and Nek8 in the proximal segment of primary cilia.

  4. cross-species analysis between zebrafish and mouse demonstrates taht NEK8 has a role in development of pronephric cysts

  5. Nek8 and Pkd1 (show PKD1 Proteins) genes function in a common pathway to regulate cystogenesis. Moreover, compound Pkd1 (show PKD1 Proteins) and Nek8 heterozygous adult mice develop a more aggressive cystic disease than animals with a mutation in either gene alone.

  6. Defects in ciliary localization of Nek8 is associated with polycystic kidney diseases

Zebrafish NIMA-Related Kinase 8 (NEK8) interaction partners

  1. requirement for Nek8 in left-right patterning is conserved

  2. Nek8 acts downstream of Inv (show INVS Proteins) function

  3. cross-species analysis between zebrafish and mouse demonstrates taht NEK8 has a role in development of pronephric cysts

Human NIMA-Related Kinase 8 (NEK8) interaction partners

  1. our study demonstrates that NEK8 (show NEK9 Proteins) human mutations cause major organ developmental defects due to altered ciliogenesis and cell differentiation/proliferation through deregulation of the Hippo pathway

  2. NEK8 (show NEK9 Proteins) may be a new target gene of HIFs; pVHL (show VHL Proteins) can down-regulate NEK8 (show NEK9 Proteins) via HIFs to maintain the primary cilia structure in human renal cancer cells

  3. NEK8 (show NEK9 Proteins) is essential for organ development and that the complete loss of NEK8 (show NEK9 Proteins) perturbs multiple signalling pathways resulting in a severe early embryonic phenotype.

  4. Mutation in NEK8 (show NEK9 Proteins) is associated with renal ciliopathies

  5. ANKS6 as a new NPHP family member that assembles a distinct module of nephronophthisis-associated proteins, encompassing NEK8 (show NEK9 Proteins), INVS (show INVS Proteins) and NPHP3 (show NPHP3 Proteins).

  6. NPHP9 promotes signalling through the transcriptional co-activator TAZ (show TAZ Proteins).

  7. study finds that induction of ciliogenesis upon cell cycle exit is accompanied by both activation and proteasomal degradation of Nek8 (show NEK9 Proteins), and that activation is dependent upon phosphorylation within the catalytic domain

  8. Data demonstrate for the first time that Nek8 (show NEK9 Proteins) is a novel tumor associated gene, and shares considerable sequence homology with the Nek family of protein kinases and may be involved in G(2)/M progression.

NEK8 Protein Profile

Protein Summary

This gene encodes a member of the serine/threionine protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans. The encoded protein may play a role in cell cycle progression from G2 to M phase. Mutations in the related mouse gene are associated with a disease phenotype that closely parallels the juvenile autosomal recessive form of polycystic kidney disease in humans.

Gene names and symbols associated with NIMA-Related Kinase 8 Proteins (NEK8)

  • NIMA (never in mitosis gene a)- related kinase 8 (NEK8)
  • NIMA (never in mitosis gene a)-related expressed kinase 8 (Nek8)
  • NIMA (never in mitosis gene a)-related kinase 8 (nek8)
  • NIMA-related kinase 8 (NEK8)
  • NIMA-related kinase 8 (Nek8)
  • 4632401F23Rik protein
  • b2b1449Clo protein
  • JCK protein
  • NEK12A protein
  • NPHP9 protein

Protein level used designations for NIMA-Related Kinase 8 Proteins (NEK8)

serine/threonine-protein kinase Nek8 , NIMA-related expressed kinase 8 , juvenile cystic kidney , never in mitosis A-related kinase 8 , nimA-related protein kinase 8 , NIMA-related kinase 8 , NIMA (never in mitosis gene a)- related kinase 8 , NIMA-family kinase NEK8 , NIMA-related kinase 12a , nephrocystin 9 , nima-related protein kinase 12a , serine/thrionine-protein kinase NEK8 , NIMA (never in mitosis gene a)-related expressed kinase 8

GENE ID SPECIES
417576 Gallus gallus
491171 Canis lupus familiaris
532332 Bos taurus
140859 Mus musculus
171094 Danio rerio
284086 Homo sapiens
287473 Rattus norvegicus
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