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The protein encoded by NEK1 is a serine/threonine kinase involved in cell cycle regulation. Additionally we are shipping NEK1 Proteins (5) and many more products for this protein.
Showing 10 out of 30 products:
Hamster Polyclonal NEK1 Primary Antibody for EIA, IHC (p) - ABIN360536
Surpili, Delben, Kobarg: Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1. in Biochemistry 2003
Show all 3 references for ABIN360536
Hamster Polyclonal NEK1 Primary Antibody for IHC (p), WB - ABIN392648
Letwin, Mizzen, Motro, Ben-David, Bernstein, Pawson: A mammalian dual specificity protein kinase, Nek1, is related to the NIMA cell cycle regulator and highly expressed in meiotic germ cells. in The EMBO journal 1992
Show all 2 references for ABIN392648
Human Polyclonal NEK1 Primary Antibody for IF (p), IHC (p) - ABIN872417
Yeo, Becherel, Luff, Graham, Richard, Lavin: Senataxin controls meiotic silencing through ATR activation and chromatin remodeling. in Cell discovery 2016
Nek1 is detectable in all murine tissues but its expression in wild type and kat2J heterozygous kidneys decrease as the kidneys mature. In the embryonic kidney, Nek1 expression is most prominent in cells that will become podocytes and proximal tubules.
results demonstrate that Nek1 is important for proper checkpoint control and characterize for the first time a DNA damage response that does not directly involve one of the known upstream mediator kinases, ATM or ATR
data suggest that TAZ (show TAZ Antibodies) and Nek1 constitute a negative feedback loop linked through phosphorylation and ubiquitination and that the interaction of Nek1 and TAZ (show TAZ Antibodies) maintain polycystin 2 (show PKD2 Antibodies) at the level needed for proper ciliogenesis
NEK1 is required for the maintenance of genome stability by acting at multiple junctures, including control of chromosome stability
Nek1 may function as a kinase early in the DNA damage response pathway.
Murine NIMA-related kinase, Nek1, is larger than previously reported, and that the full-length protein conserves the structural hallmarks of NIMA
Nek1 links cell cycle progression and the primary cilium cycle.
we propose that Nek1 plays a role in centrosome integrity, affecting both ciliogenesis and centrosome stability
These data show that Nek1 is important for efficient DNA damage checkpoint control and for proper DNA damage repair.
NEK1 is a candidate to transduce messages from the ciliary-basal body region to the regulation of nuclear gene expression.
Nek1 overexpression in gliomas was correlated with the proliferation marker (Ki-67 (show MKI67 Antibodies)), tumor grade, Karnofsky performance scale (KPS) and more importantly, patients' poor survival. Further studies showed that Nek1 expression level was also increased in multiple glioma cell lines (U251-MG, U87-MG, U118, H4 and U373).
C21ORF2 (show C21orf2 Antibodies) functions in the same pathway as NEK1 in DNA damage repair.
Nek1 may facilitate S-phase progression by interacting with Ku80 (show XRCC5 Antibodies) and regulating chromatin loading of replication factors.
Nek1 may suppress cilia by phosphorylating pVHL (show VHL Antibodies), which is critical to microtubule stabilization and ciliary stability.
as an ATR (show ANTXR1 Antibodies)-associated kinase, Nek1 enhances the stability and activity of ATR (show ANTXR1 Antibodies)-ATRIP (show ATRIP Antibodies) before DNA damage, priming ATR (show ANTXR1 Antibodies)-ATRIP (show ATRIP Antibodies) for a robust DNA damage response
The present case provides evidence for a correlation of NEK1 mutation with short rib-polydactyly syndrome type II (Majewski.
This study confirms that NEK1 is one gene causing SRP type II but also reports mutations in DYNC2H1, expanding the phenotypic spectrum of DYNC2H1 mutations.
absence of functional full-length NEK1 severely reduces cilia number and alters ciliar morphology in vivo.
Nek1 is involved in the beginning of the cellular response to genotoxic stress and plays an important role in preventing cell death induced by DNA damage.
The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have been found for this gene.
NIMA-related kinase 1
, NY-REN-55 antigen
, Nek1 serine/threonine- and tyrosine-specific protein kinase
, kidney, anemia and testis
, never in mitosis A-related kinase 1
, nimA-related protein kinase 1
, serine/threonine-protein kinase Nek1
, NIMA (never in mitosis gene a)-related kinase 1
, protein-serine/threonine kinase
, renal carcinoma antigen NY-REN-55
, NIMA (never in mitosis gene a)-related expressed kinase 1